Antiviral activity of macrocyclic polyethers and their complexes with the alkaline metal salts of N-phosphorylated amides and thioamides

Zabirov, N. G.; Поздеев, О. К.; Shcherbakova, V. A.; Shumilova, T. N.; Черкасов, Р. А.; Gil'manova, G. Kh.

doi:10.1007/bf00772123

Cited by 3 publications

(3 citation statements)

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“…As for future perspectives on pillararene-based drug delivery systems, one also can mention the lack of reports on the application of pillararenes as carriers for antiviral drug delivery, while antiviral drugs carriers were reported for other classes of macrocycles [ 117 , 118 ]. Additionally, due to a wide range of binding motifs, pillararenes offer the potential to interact directly with viruses and inhibit infection, for instance, it was reported for human papillomavirus [ 119 ].…”

Section: Discussionmentioning

confidence: 99%

Pillararenes as Promising Carriers for Drug Delivery

Zyryanov

Kopchuk

Коvalev

et al. 2023

IJMS

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Since their discovery in 2008 by N. Ogoshi and co-authors, pillararenes (PAs) have become popular hosts for molecular recognition and supramolecular chemistry, as well as other practical applications. The most useful property of these fascinating macrocycles is their ability to accommodate reversibly guest molecules of various kinds, including drugs or drug-like molecules, in their highly ordered rigid cavity. The last two features of pillararenes are widely used in various pillararene-based molecular devices and machines, stimuli-responsive supramolecular/host–guest systems, porous/nonporous materials, organic–inorganic hybrid systems, catalysis, and, finally, drug delivery systems. In this review, the most representative and important results on using pillararenes for drug delivery systems for the last decade are presented.

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Section: Discussionmentioning

confidence: 99%

Pillararenes as Promising Carriers for Drug Delivery

Zyryanov

Kopchuk

Коvalev

et al. 2023

IJMS

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“…Macrocyclic compounds are frequently used as drug carriers [15, 16], including as carriers for antivirals [17, 18]. Additionally, due to their wide range of binding motifs, macrocycles offer the potential to interact directly with viruses and inhibit infection.…”

Section: Introductionmentioning

confidence: 99%

Broad-spectrum extracellular antiviral properties of Cucurbit[n]urils

Jones

Super

Batt

et al. 2022

Preprint

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Viruses are microscopic pathogens capable of causing disease and are responsible for a range of human mortality and morbidity worldwide. They can be rendered harmless or destroyed with a range of antiviral chemical compounds. Cucurbit[n]urils (CB[n]s) are a macrocycle chemical compound existing as a range of homologues; due to their structure they can bind to biological materials, acting as supramolecular host to guests, such as amino acids. Due to the increasing need for a non-toxic antiviral compound, we investigated whether cucurbit[n]urils could act in an antiviral manner. We have found that certain cucurbit[n]uril homologues do indeed have an antiviral effect against a range of viruses, including RSV and SARS-CoV-2. In particular, we demonstrate that CB[7] is the active homologue of CB[n] mixtures, having an antiviral effect against enveloped and non-enveloped species. High levels of efficacy were observed with five-minute contact times across different viruses. We also demonstrate that CB[7] acts with an extracellular virucidal mode of action via host-guest supramolecular interactions between viral surface proteins and the CB[n] cavity, rather than via cell internalisation or a virustatic mechanism. This finding demonstrates that CB[7] acts as a supramolecular virucidal antiviral (a mechanism distinct from other current extracellular antivirals) demonstrating the potential of supramolecular interactions for future antiviral disinfectants.

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“…Macrocyclic compounds are frequently used as drug carriers, , including as carriers for antivirals. , Additionally, due to their wide range of binding motifs, macrocycles offer the potential to interact directly with viruses and inhibit infection. However, to date, the use of macrocycles as antivirals has been limited to modified macrocycles or via indirect effects (for example, via binding cholesterol).…”

mentioning

confidence: 99%

Broad-Spectrum Extracellular Antiviral Properties of Cucurbit[n]urils

et al. 2022

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Viruses are microscopic pathogens capable of causing disease and are responsible for a range of human mortalities and morbidities worldwide. They can be rendered harmless or destroyed with a range of antiviral chemical compounds. Cucurbit[ n ]urils (CB[ n ]s) are a family of macrocycle chemical compounds existing as a range of homologues; due to their structure, they can bind to biological materials, acting as supramolecular “hosts” to “guests”, such as amino acids. Due to the increasing need for a nontoxic antiviral compound, we investigated whether cucurbit[ n ]urils could act in an antiviral manner. We have found that certain cucurbit[ n ]uril homologues do indeed have an antiviral effect against a range of viruses, including herpes simplex virus 2 (HSV-2), respiratory syncytial virus (RSV) and SARS-CoV-2. In particular, we demonstrate that CB[7] is the active homologue of CB[ n ], having an antiviral effect against enveloped and nonenveloped species. High levels of efficacy were observed with 5 min contact times across different viruses. We also demonstrate that CB[7] acts with an extracellular virucidal mode of action via host–guest supramolecular interactions between viral surface proteins and the CB[ n ] cavity, rather than via cell internalization or a virustatic mechanism. This finding demonstrates that CB[7] acts as a supramolecular virucidal antiviral (a mechanism distinct from other current extracellular antivirals), demonstrating the potential of supramolecular interactions for future antiviral disinfectants.

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Antiviral activity of macrocyclic polyethers and their complexes with the alkaline metal salts of N-phosphorylated amides and thioamides

Cited by 3 publications

References 0 publications

Pillararenes as Promising Carriers for Drug Delivery

Pillararenes as Promising Carriers for Drug Delivery

Broad-spectrum extracellular antiviral properties of Cucurbit[n]urils

Broad-Spectrum Extracellular Antiviral Properties of Cucurbit[n]urils

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