Antiviral activity of luteolin against Japanese encephalitis virus

Fan, Wenchun; Qian, Suhong; Qian, Ping; Li, Xiangmin

doi:10.1016/j.virusres.2016.04.021

Cited by 139 publications

(70 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The virucidal activity of luteolin was observed in A549 cell lines infected with JEV, and reported that luteolin inhibits the viral replication at the post entry of virus. Luteolin did not inhibit the replication at the time of viral entry (Fan et al 2016). More recently, a group of researchers have identified pinocembrin having anti-Zika activity.…”

Section: Flavonoids As Antiviral Agentsmentioning

confidence: 92%

Phytochemicals as Antiviral Agents: Recent Updates

Ghildiyal

Prakash

Chaudhary

et al. 2020

Plant-Derived Bioactives

123

View full text Add to dashboard Cite

Section: Flavonoids As Antiviral Agentsmentioning

confidence: 92%

Phytochemicals as Antiviral Agents: Recent Updates

Ghildiyal

Prakash

Chaudhary

et al. 2020

Plant-Derived Bioactives

123

View full text Add to dashboard Cite

“…The owers are given in the form of syrup or with honey as a domestic remedy for bronchial asthma, colds, cough 39 . Luteolin which is a avonoid exhibited potent antiviral activity against SARS coronavirus 40 , Japanese encephalitis virus 41 . It also inhibited HIV-1 protease in cell-free assays 42 .…”

Section: Discussionmentioning

confidence: 99%

Antiviral potential of phytoligands against chymotrypsin-like protease of COVID‐19 virus using molecular docking studies: An optimistic approach

Mishra¹,

Kumari²,

Yadav³

et al. 2020

Preprint

View full text Add to dashboard Cite

A recent outbreak of the novel coronavirus, COVID‐19, in the city of Wuhan, Hubei province, China and its ensuing worldwide spread have resulted in lakhs of infections and thousands of deaths. As of now, there are no registered therapies for treating the contagious COVID‐19 infections, henceforth drug repositioning may provide a fast way out. In the present study, a total of thirty-five compounds including commonly used anti-viral drugs were screened against chymotrypsin-like protease (3CLpro) using SwissDock. Interaction between amino acid of targeted protein and ligands was visualized by UCSF Chimera. Docking studies revealed that the phytochemicals such as cordifolin, anisofolin A, apigenin 7-glucoside, luteolin, laballenic acid, quercetin, luteolin-4-glucoside exhibited significant binding energy with the enzyme viz. - 8.77, -8.72, -8.36, -8.35, -8.13, -8.04 and -7.87 Kcal/Mol respectively. Therefore, new lead compounds can be used for drug development against SARS‐CoV‐2 infections.

show abstract

“…Xu et al [142] tested 400 highly purified natural compounds for inhibition of EV71 and coxsackievirus A16 infections and found that luteolin exhibited the most potent inhibition through disruption of viral RNA replication. Besides these antiviral activities, luteolin or luteolin-rich fractions showed antiviral effects against severe acute respiratory syndrome coronavirus (SARS-CoV), rhesus rotavirus, CHIKV and Japanese encephalitis virus (JEV) [33,67,94,146].…”

Section: Antiviral Activity Of Flavonesmentioning

confidence: 99%

Flavonoids: promising natural compounds against viral infections

et al. 2017

View full text Add to dashboard Cite

Flavonoids are widely distributed as secondary metabolites produced by plants and play important roles in plant physiology, having a variety of potential biological benefits such as antioxidant, anti-inflammatory, anticancer, antibacterial, antifungal and antiviral activity. Different flavonoids have been investigated for their potential antiviral activities and several of them exhibited significant antiviral properties in in vitro and even in vivo studies. This review summarizes the evidence for antiviral activity of different flavonoids, highlighting, where investigated, the cellular and molecular mechanisms of action on viruses. We also present future perspectives on therapeutic applications of flavonoids against viral infections.

show abstract

Antiviral activity of luteolin against Japanese encephalitis virus

Cited by 139 publications

References 29 publications

Phytochemicals as Antiviral Agents: Recent Updates

Phytochemicals as Antiviral Agents: Recent Updates

Antiviral potential of phytoligands against chymotrypsin-like protease of COVID‐19 virus using molecular docking studies: An optimistic approach

Flavonoids: promising natural compounds against viral infections

Contact Info

Product

Resources

About