Antiviral activity of
            <i>Humulus lupulus</i>
            (HOP) aqueous extract against MERS-CoV and SARS-CoV-2: in-vitro and in-silico study

Bouback, Thamer A.; Aljohani, Amal Mohammed; Albeshri, Abdulaziz; Al-Talhi, Hasan A.; Moatasim, Yassmin; Gaballah, Mohamed S.; Badierah, Raied; Albiheyri, Raed; Al-Sarraj, Faisal; Ali, Mohamed A.

doi:10.1080/13102818.2022.2158133

Cited by 5 publications

(1 citation statement)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Laurus nobilis essential oil, with beta-ocimene, 1,8-cineole, alpha-pinene, and beta-pinene as its main constituents, has also been shown to exert antiviral activity against SARS-CoV, with an IC 50 value of 120 mg/mL [13] . More recent works reviewed the antiviral activity of plant secondary metabolites as a possible SARS-CoV-2 Treatment [14] , assessed the Antiviral activity of Humulus lupulus against MERS-CoV using in-vitro and in-silico tools [15] and investigated the antiviral effects of Saussurea lappa root extract against SARS-CoV-2 in vitro and in animal models [16] .…”

Section: Introductionmentioning

confidence: 99%

Terpenes and cannabidiol against human corona and influenza viruses–Anti-inflammatory and antiviral in vitro evaluation

Chatow,

Nudel,

Eyal

et al. 2024

Biotechnology Reports

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Terpenes and cannabidiol against human corona and influenza viruses–Anti-inflammatory and antiviral in vitro evaluation

Chatow,

Nudel,

Eyal

et al. 2024

Biotechnology Reports

View full text Add to dashboard Cite

The Therapeutic Potential of Natural Dietary Flavonoids against SARS-CoV-2 Infection

Wang

Yang

2023

Nutrients

View full text Add to dashboard Cite

The exploration of non-toxic and cost-effective dietary components, such as epigallocatechin 3-gallate and myricetin, for health improvement and disease treatment has recently attracted substantial research attention. The recent COVID-19 pandemic has provided a unique opportunity for the investigation and identification of dietary components capable of treating viral infections, as well as gathering the evidence needed to address the major challenges presented by public health emergencies. Dietary components hold great potential as a starting point for further drug development for the treatment and prevention of SARS-CoV-2 infection owing to their good safety, broad-spectrum antiviral activities, and multi-organ protective capacity. Here, we review current knowledge of the characteristics—chemical composition, bioactive properties, and putative mechanisms of action—of natural bioactive dietary flavonoids with the potential for targeting SARS-CoV-2 and its variants. Notably, we present promising strategies (combination therapy, lead optimization, and drug delivery) to overcome the inherent deficiencies of natural dietary flavonoids, such as limited bioavailability and poor stability.

show abstract

ECHOPvir: A Mixture of Echinacea and Hop Extracts Endowed with Cytoprotective, Immunomodulatory and Antiviral Properties

Percaccio,

De Angelis,

Acquaviva

et al. 2023

Nutrients

View full text Add to dashboard Cite

Respiratory viral infections continue to pose significant challenges, particularly for more susceptible and immunocompromised individuals. Nutraceutical strategies have been proposed as promising strategies to mitigate their impact and improve public health. In the present study, we developed a mixture of two hydroalcoholic extracts from the aerial parts of Echinacea purpurea (L.) Moench (ECP) and the cones of Humulus lupulus L. (HOP) that can be harnessed in the prevention and treatment of viral respiratory diseases. The ECP/HOP mixture (named ECHOPvir) was characterized for the antioxidant and cytoprotective properties in airway cells. Moreover, the immunomodulating properties of the mixture in murine macrophages against antioxidant and inflammatory stimuli and its antiviral efficacy against the PR8/H1N1 influenza virus were assayed. The modulation of the Nrf2 was also investigated as a mechanistic hypothesis. The ECP/HOP mixture showed a promising multitarget bioactivity profile, with combined cytoprotective, antioxidant, immunomodulating and antiviral activities, likely due to the peculiar phytocomplexes of both ECP and HOP, and often potentiated the effect of the single extracts. The Nrf2 activation seemed to trigger these cytoprotective properties and suggest a possible usefulness in counteracting the damage caused by different stressors, including viral infection. Further studies may strengthen the interest in this product and underpin its future nutraceutical applications.

show abstract

Antiviral activity of Humulus lupulus (HOP) aqueous extract against MERS-CoV and SARS-CoV-2: in-vitro and in-silico study

Cited by 5 publications

References 44 publications

Terpenes and cannabidiol against human corona and influenza viruses–Anti-inflammatory and antiviral in vitro evaluation

Terpenes and cannabidiol against human corona and influenza viruses–Anti-inflammatory and antiviral in vitro evaluation

The Therapeutic Potential of Natural Dietary Flavonoids against SARS-CoV-2 Infection

ECHOPvir: A Mixture of Echinacea and Hop Extracts Endowed with Cytoprotective, Immunomodulatory and Antiviral Properties

Contact Info

Product

Resources

About