Antiviral Activity of Hemocyanin Isolated from Marine Snail Rapana venosa

Nesterova, N. V.; Zagorodnya, Svіtlana; Moshtanska, Vesela; Dolashka, Pavlina; Баранова, Г. В.; Golovan, Anna; Kurova, Anna O.

doi:10.1016/j.antiviral.2011.03.052

Cited by 27 publications

(13 citation statements)

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“…Molluscan hemocyanins, copper-containing oxygen transport macromolecules, have also been observed to be multifunctional, with innate immune functions, including antiviral activity, as demonstrated against the herpesviruses herpes simplex virus (HSV) and Epstein-Barr virus (EBV), in the abalone H. rubra (51) and the veined whelk Rapana venosa (32,43). These observations were extended to include Rapana venosa activity against HSV-1 and HSV-2 (39).…”

Section: Structures and Mechanisms Of Action Of Molluscan Antiviral Cmentioning

confidence: 93%

Marine Snails and Slugs: a Great Place To Look for Antiviral Drugs

Vinh

Benkendorff

Green

et al. 2015

J Virol

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e Molluscs, comprising one of the most successful phyla, lack clear evidence of adaptive immunity and yet thrive in the oceans, which are rich in viruses. There are thought to be nearly 120,000 species of Mollusca, most living in marine habitats. Despite the extraordinary abundance of viruses in oceans, molluscs often have very long life spans (10 to 100 years). Thus, their innate immunity must be highly effective at countering viral infections. Antiviral compounds are a crucial component of molluscan defenses against viruses and have diverse mechanisms of action against a wide variety of viruses, including many that are human pathogens. Antiviral compounds found in abalone, oyster, mussels, and other cultured molluscs are available in large supply, providing good opportunities for future research and development. However, most members of the phylum Mollusca have not been examined for the presence of antiviral compounds. The enormous diversity and adaptations of molluscs imply a potential source of novel antiviral compounds for future drug discovery.

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Section: Structures and Mechanisms Of Action Of Molluscan Antiviral Cmentioning

confidence: 93%

Marine Snails and Slugs: a Great Place To Look for Antiviral Drugs

Vinh

Benkendorff

Green

et al. 2015

J Virol

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“…Proteins and glycoproteins are the most abundant compounds found in molluscan extracts active against viruses (Dang et al., ). To quote some examples, kelletinin A ( B. corneum ) has been found active against Human T‐cell leukemia virus type 1 (Orlando, Strazzullo, Carretta, De Falco, & Grippo, ; Silvestri et al., ), hemocyanin ( R. venosa ) against Respiratory syncytial virus, Herpes simplex virus (HSV)‐1 and ‐2, and Epstein–Barr virus (EBV) (Dolashka et al., ; Dolashka‐Angelova et al., ; Genova‐Kalou et al., ; Nesterova et al., ), mytilin ( M. galloprovincialis ) against White spot syndrome virus (Dupuy et al., ), defensin ( M. galloprovincialis ) against human immunodeficiency virus type 1 (HIV‐1) (Roch et al., ), while lectin ( C. grayanus ) against HIV (Luk'yanov et al., ). Though their exact mechanism of action is hitherto unknown, apparently, they counteract invading virus either by directly inactivating it and preventing its binding to or entrance into target cells or by inhibiting its replication and transcription (Dang et al., ).…”

Section: Health‐promoting Efficacy Of Marine Mollusksmentioning

confidence: 99%

Marine Mollusks: Food with Benefits

Khan

Yang

2019

Comp Rev Food Sci Food Safe

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The extremely vast biodiversity represented by marine mollusks alongside their widespread utility as a source of food and their high nutritional value has aroused great interest from the scientific community. Furthermore, they can be caught with ease, and their commercial breeding and farming is rampant. This article comprehends the global availability of these organisms, their pretreatment and handling procedures, and their health‐promoting potential with a focus on their antiviral, anti‐inflammatory, and antimicrobial properties. The emphasis herein is on their potential use in the food and nutraceutical industry. In addition, mollusks consumption as part of everyday diet can also be helpful in avoiding many ailments as they are rich in vital nutrients and active secondary metabolites, as well as have the ability to enhance immune response. Moreover, the available literature suggests that normal cooking practices have no notable adverse effects on their nutritional value and they retain certain bioactivities even after the action of digestive enzymes. Though mollusks have been widely studied in relation to the health‐promoting effects reviewed here, there is still more scope for further research in this direction in order to fully utilize this enormous source of food and nutraceuticals.

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“…15,16 Moreover, also the antiviral activity of molluscan hemocyanins (RvH, β-HlH, KLH, and Haliotis tuberculata hemocyanin (HtH)), which is also based on the presence of carbohydrate structures, has recently drawn considerable attention. [17][18][19][20][21][22][23][24][25] The carbohydrate content of molluscan hemocyanins (2-9%, w/w) is higher than that of most arthropod hemocyanins. 26,27 Moreover, hemocyanins of Helix pomatia (HpH) and Lymnaea stagnalis contain monosaccharides not usually found in animal glycoproteins (H. pomatia: D-xyl and 3-O-methyl-D-galactose (3MeGal) 28,29 ; L. stagnalis: D-Xyl, 3-O-methyl-D-mannose (3MeMan), and 3MeGal) 30 .…”

Section: Introductionmentioning

confidence: 99%

N-glycan structures of β-HlH subunit of Helix lucorum hemocyanin

Velkova

Dolashka

Beeumen

et al. 2017

Carbohydrate Research

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The carbohydrate structures of molluscan hemocyanins have recently received particular interest due to their specific monosaccharide composition, as well as their immunostimulatory properties and application in clinical studies. For the first time, we investigated N-glycans of the structural subunit β-HlH of hemocyanin isolated from Helix lucorum. In total, 32 different glycans were enzymatically liberated and characterized by tandem mass spectrometry using a Q-Trap mass spectrometer. Our study revealed a highly heterogeneous mixture of glycans with composition HexHexNAcMeHexPentFuc. The oligosaccharide chains are mostly modified at the inner core by β1-2-linked xylose to β-mannose, by α1-6-fucosylation of the innermost GlcNAc residue (the Asn-bound GlcNAc), and by methylation. The glycans of β-HlH mainly contain a terminal MeHex residue; in some cases even two, three or four of these residues occur. Several carbohydrate chains in β-HlH are core-fucosylated without Xyl and also possess a high degree of methylation. This study shows the presence of mono- and bi-antennary N-glycans as well as hybrid type structures with or without core-fucosylation.

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Antiviral Activity of Hemocyanin Isolated from Marine Snail Rapana venosa

Cited by 27 publications

References 0 publications

Marine Snails and Slugs: a Great Place To Look for Antiviral Drugs

Marine Snails and Slugs: a Great Place To Look for Antiviral Drugs

Marine Mollusks: Food with Benefits

N-glycan structures of β-HlH subunit of Helix lucorum hemocyanin

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