Antiviral Activity of Gossypol and Apogossypol

Dorsett, Preston H.; Kerstine, Edwin E.; Powers, Larry J.

doi:10.1002/jps.2600640654

Cited by 52 publications

(18 citation statements)

References 10 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mice treated with gossypol showed a 96-100% protection rate against the virus (Dorsett et at., 1975). Apogossypol, the decarbonylation derivative of gossypol, and gossypol were found to inactivate the enveloped parainfluenza-3 and herpes simplex viruses in vitro using HEp-2 cells in cultures (Dorsett et ai., 1975).…”

Section: Toxicity To Microorganismsmentioning

confidence: 97%

Toxicological effects of gossypol

Nomeir¹,

Abou‐Donia²

1985

Male Fertility and Its Regulation

View full text Add to dashboard Cite

Section: Toxicity To Microorganismsmentioning

confidence: 97%

Toxicological effects of gossypol

Nomeir¹,

Abou‐Donia²

1985

Male Fertility and Its Regulation

View full text Add to dashboard Cite

“…Gossypol exhibits multiple biological properties, including spermicidal, 1 antiparasitic, 2 anticancer, 3 and antiviral activities. 4 Gossypol displays potent inhibition against anti-apoptotic Bcl-2 family proteins where it functions as a BH3 mimic. 5 (−)-Gossypol is currently in phase II clinical trails, displaying single-agent antitumor activity in patients with advanced malignancies.…”

mentioning

confidence: 99%

Synthesis of hemigossypol and its derivatives

Wei

Jagt

Royer

et al. 2010

Tetrahedron Letters

View full text Add to dashboard Cite

Hemigossypol (3), a sesquiterpene natural product, was previously isolated from Gossypium barbadense and was shown to display improved anti-fungal activity compared to gossypol (1), the disesquiterpene dimer of hemigossypol (3). Gossypol exhibits multiple biological activities. In order to study whether hemigossypol and it derivatives retain the various bioactivities of gossypol, we developed a short and convenient synthetic scheme to synthesize hemigossypol. This is the first de novo synthesis of this natural product. In addition derivatives of hemigossypol with various 2,5-alkyl substituents were synthesized. Modification of the synthetic scheme also afforded the natural product hemigossylic lactone (4) and its 2,5-substituted derivatives.

show abstract

“…Of relevance to our present study are the reports of the antiviral activity of gossypol against herpes simplex virus type 2 (5,19,29), parainfluenza virus (5), and influenza virus (8) and in therapy of experimental influenza pneumonia in mice (27). In contrast, poliovirus was not inhibited (5).…”

mentioning

confidence: 92%