Antiviral Activity of Fullerene-(Tris-Aminocaproic Acid) Hydrate Against Respiratory Syncytial Virus in HEp-2 Cell Culture

Фалынскова, И. Н.; Ионова, К. С.; Dedova, A. V.; Ленева, И. А.; Махмудова, Н. Р.; Rasnetsov, Lev

doi:10.1007/s11094-014-1053-3

Cited by 12 publications

(7 citation statements)

References 9 publications

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“…Besides HIV, the inhibition of viral activity by fullerene derivatives has been tested for hepatitis C virus (HCV), 82 respiratory syncytial virus (RSV), 83 virus H1N1, herpes simplex virus, 84 human cytomegalovirus, 84 Zika and Dengue viruses. 85…”

Section: Fullerenes As Anti-hiv Agentsmentioning

confidence: 99%

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

2020

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Section: Fullerenes As Anti-hiv Agentsmentioning

confidence: 99%

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

2020

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“…The radioprotection of this type of blood cells is a highly important task for national health services, particularly for the protection of cancer patients routinely undergoing radiotherapy as a vital component of anticancer treatment. Moreover, the antiviral potential of EACA would be also beneficial for application in oncological clinics [32,114]. It is well known that chemotherapy causes the suppression of the immune system, thus increasing the risk of viral infections that predominantly attack the respiratory tract [115,116].…”

Section: Discussionmentioning

confidence: 99%

A New Insight on the Radioprotective Potential of Epsilon-Aminocaproic Acid

et al. 2020

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Background and objectives: The aim of the study was to scrutinize the ability of epsilon-aminocaproic acid (EACA) to prevent radiation-induced damage to human cells. Materials and Methods: Human peripheral blood mononuclear cells (PBMCs) were exposed to ionizing radiation at three low doses (22.62 mGy, 45.27 mGy, and 67.88 mGy) in the presence of EACA at the concentration of 50 ng/mL. Results: EACA was able to prevent cell death induced by low-dose X-ray radiation and suppress the formation of reactive oxygen species (ROS). EACA also demonstrated a capacity to protect DNA from radiation-induced damage. The data indicated that EACA is capable of suppression of radiation-induced apoptosis. Comparative tests of antioxidative activity of EACA and a range of free radical scavengers showed an ability of EACA to effectively inhibit the generation of ROS. Conclusions: This study showed that the pretreatment of PBMCs with EACA is able to protect the cells from radiation-elicited damage, including free radicals’ formation, DNA damage, and apoptosis.

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“…Fullerene-(tris-aminocaproic acid) hydrate was designed, and their activity against the respiratory syncytial virus was studied [ 122 ]. Fullerene modified with thiosialosyl-a (2,6)-galactose disaccharide was synthesized and investigated for interaction with influenza viral proteins HA and NA.…”

Section: Nanocarriers For Delivery Of Antiviral Agentsmentioning

confidence: 99%

Human respiratory viral infections: Current status and future prospects of nanotechnology-based approaches for prophylaxis and treatment

Dawre

Maru

2021

Life Sciences

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Antiviral Activity of Fullerene-(Tris-Aminocaproic Acid) Hydrate Against Respiratory Syncytial Virus in HEp-2 Cell Culture

Cited by 12 publications

References 9 publications

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

A New Insight on the Radioprotective Potential of Epsilon-Aminocaproic Acid

Human respiratory viral infections: Current status and future prospects of nanotechnology-based approaches for prophylaxis and treatment

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