Antiviral Activity of Flavonoids from Bauhinia holophylla Leaves against Zika virus
Rodrigo Michelini de Oliveira Thomasi,
Thaiz Rodrigues Teixeira,
Gabriela Francine Martins Lopes
et al.
Abstract:Zika virus (ZIKV) is involved in the etiology of serious nervous system pathologies. Currently, there are no specific and effective vaccines or antiviral drugs to prevent the diseases caused by ZIKV. This study aimed to assess the activity of flavonoids present in crude hydroethanolic extract (CHE) and fractions obtained from B. holophylla leaves against ZIKV. O-glycosylated flavonoids were characterized by high-performance liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS/MS). The … Show more
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