Antiviral activity of ethanol extract of Lophatherum gracile against respiratory syncytial virus infection

Chen, Lifeng; Zhong, Yuan‐Lin; Luo, Dan; Liu, Zhong; Tang, Wei; Cheng, Wen; Xiong, Si; Li, Man‐Mei

doi:10.1016/j.jep.2018.10.036

Cited by 34 publications

(24 citation statements)

References 46 publications

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“…Schefflera heptaphylla ‐derived dicaffeoylquinic acids also hindered RSV replication (Li et al, 2005b). The ethanol extract of Lophatherum gracile suppressed RSV infection and inflammation prompted in a dose‐dependent manner (Chen et al, 2019).…”

Section: Antiviral Molecules Of Plant Originmentioning

confidence: 99%

Medicinal plants: Treasure for antiviral drug discovery

Ali

Sheikh

Rather

et al. 2021

Phytotherapy Research

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The pandemic of viral diseases like novel coronavirus (2019‐nCoV) prompted the scientific world to examine antiviral bioactive compounds rather than nucleic acid analogous, protease inhibitors, or other toxic synthetic molecules. The emerging viral infections significantly associated with 2019‐nCoV have challenged humanity's survival. Further, there is a constant emergence of new resistant viral strains that demand novel antiviral agents with fewer side effects and cell toxicity. Despite significant progress made in immunization and regenerative medicine, numerous viruses still lack prophylactic vaccines and specific antiviral treatments that are so often influenced by the generation of viral escape mutants. Of importance, medicinal herbs offer a wide variety of therapeutic antiviral chemotypes that can inhibit viral replication by preventing viral adsorption, adhering to cell receptors, inhibiting virus penetration in the host cell, and competing for pathways of activation of intracellular signals. The present review will comprehensively summarize the promising antiviral activities of medicinal plants and their bioactive molecules. Furthermore, it will elucidate their mechanism of action and possible implications in the treatment/prevention of viral diseases even when their mechanism of action is not fully understood, which could serve as the base for the future development of novel or complementary antiviral treatments.

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Section: Antiviral Molecules Of Plant Originmentioning

confidence: 99%

Medicinal plants: Treasure for antiviral drug discovery

Ali

Sheikh

Rather

et al. 2021

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…A study of isoorientin provides a convincing and powerful support for the traditional use of Lophatherum gracile Brongn. in the RSV-related diseases treatment ( Chen et al, 2019 ). Following the probit analysis of brine shrimp lethality assay, the LD 50 values of isoorientin were calculated to be more than 1000 μg/ml compared to cytotoxic lignan podophyllotoxin with 2.79 μg/ml.…”

Section: Natural Products With Reported Activities Against Viral Pneumentioning

confidence: 99%

Overview of Viral Pneumonia Associated With Influenza Virus, Respiratory Syncytial Virus, and Coronavirus, and Therapeutics Based on Natural Products of Medicinal Plants

Lin

Chen

et al. 2021

Front. Pharmacol.

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Viral pneumonia has been a serious threat to global health, especially now we have dramatic challenges such as the COVID-19 pandemic. Approximately six million cases of community-acquired pneumonia occur every year, and over 20% of which need hospital admission. Influenza virus, respiratory virus, and coronavirus are the noteworthy causative agents to be investigated based on recent clinical research. Currently, anaphylactic reaction and inflammation induced by antiviral immunity can be incriminated as causative factors for clinicopathological symptoms of viral pneumonia. In this article, we illustrate the structure and related infection mechanisms of these viruses and the current status of antiviral therapies. Owing to a set of antiviral regiments with unsatisfactory clinical effects resulting from side effects, genetic mutation, and growing incidence of resistance, much attention has been paid on medicinal plants as a natural source of antiviral agents. Previous research mainly referred to herbal medicines and plant extracts with curative effects on viral infection models of influenza virus, respiratory virus, and coronavirus. This review summarizes the results of antiviral activities of various medicinal plants and their isolated substances, exclusively focusing on natural products for the treatment of the three types of pathogens that elicit pneumonia. Furthermore, we have introduced several useful screening tools to develop antiviral lead compounds.

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“…Cell viability was determined using the tetrazolium salt 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT; Biotopped. 13 Hep-2 cells in log growth phase were inoculated at 1 × 10 4 per well into 96-well plates and incubated for 24 h.…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

Screening and pharmacodynamic evaluation of the antirespiratory syncytial virus activity of steroidal pyridine compounds in vitro and in vivo

Wang

Hou

Fang

et al. 2020

Journal of Medical Virology

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Respiratory syncytial virus (RSV) causes serious lower respiratory tract infections and there are currently no safer or more effective drugs available. It is important to find novel medications for RSV infection. A series of steroidal pyridines were synthesized for screening and evaluation of their antiviral activity and investigation of their antiviral mechanism of action. Compound 3l had the highest antiviral activity, with a half‐maximal effective concentration (EC50) of 3.13 μM. Compound 3l was explored for its effects in vitro on RSV 2 h before infection (pretreatment), at the time of infection (competition), and 2 h after infection (postinfection). Toll‐like receptor (TLR)‐3, retinoic acid‐inducible gene (RIG)‐I, interleukin (IL)‐6, and interferon (IFN)‐β were suppressed at the cellular level. Mouse lung tissue was subjected to hematoxylin and eosin (HE) staining and immunohistochemistry, which showed that RSV antigen and M gene expression could be reduced by compound 3l. Decreased expression of TLR‐3, RIG‐I, IL‐6, IFN‐β, and IL‐10 was also found in vivo. The results indicated that compound 3l exerted its antiviral effects mainly through inhibition of viral replication and downregulation of inflammatory factors.

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Antiviral activity of ethanol extract of Lophatherum gracile against respiratory syncytial virus infection

Cited by 34 publications

References 46 publications

Medicinal plants: Treasure for antiviral drug discovery

Medicinal plants: Treasure for antiviral drug discovery

Overview of Viral Pneumonia Associated With Influenza Virus, Respiratory Syncytial Virus, and Coronavirus, and Therapeutics Based on Natural Products of Medicinal Plants

Screening and pharmacodynamic evaluation of the antirespiratory syncytial virus activity of steroidal pyridine compounds in vitro and in vivo

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