Antiviral Activity of Chitosan Nanoparticles Encapsulating Curcumin Against Hepatitis C Virus Genotype 4a in Human Hepatoma Cell Lines [Retraction]

Loutfy, Samah A.; Elberry, Mostafa H.; Farroh, Khaled Yehia; Mohamed, Hossam Taha; Mohamed, Aya Ali; Mohamed, El-Chaimaa B.; Faraag, Ahmed Hassan Ibrahim; Mousa, Shaker A.

doi:10.2147/ijn.s380656

Cited by 4 publications

(3 citation statements)

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“…In addition, CS helps drugs to cross biological barriers more easily [15]. Recent studies have drawn attention to the CS nanoparticles in developing a drug delivery system that will increase the therapeutic efficacy of antiviral agents and reduce the therapeutic dose [20]. Although there are many studies on the delivery of various drugs through CS hydrogels, there have been few studies on the delivery of antiviral drugs with low bioavailability by the hydrogel system.…”

Section: Introductionmentioning

confidence: 99%

Tenofovir Disoproxil Fumarate Release From Glutaraldehyde Cross-Linked Chitosan/Β-Cyclodextrin Hydrogel

Yaman,

Erdogan,

Taşdelen

2024

Hacettepe Journal of Biology and Chemistry

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In this study, chitosan was produced from crayfish Astacus leptodactylus, and then it was used to synthesize chitosan-graft-β-cyclodextrin (CS-g-β-CD) hydrogel. The produced chitosan (CS) and the sythesized CS-g-β-CD hydrogel were characterized using a Fourier Transform Infrared Spectroscopy (FTIR), Proton Nuclear Magnetic Resonance Spectroscopy (1H-NMR), X-ray Diffraction (XRD), and Scanning Electron Microscopy (SEM). Tenofovir disoproxil fumarate (TDF) was used as a model to investigate the antiviral drug release properties of the CS-g-β-CD hydrogel. The synthesized hydrogel had an almost homogeneous pore structure and a high swelling capacity which increases depending on the amount of β-Cyclodextrin (β-CD). The drug-loaded CS-g-β-CD hydrogels was examined by XRD and 1H-NMR, and SEM analyses. Seventy-three percent of the TDF loaded on the synthesized hydrogels was released into phosphate-buffered saline (PBS) solution at 37 ºC. The drug release behavior of all prepared CS-g-β-CD hydrogels fitted the Korsmeyer-Peppas model. The addition of β-CD into the gel improved the swelling ability and TDF release of the CS-g-β-CD hydrogel system.

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Section: Introductionmentioning

confidence: 99%

Tenofovir Disoproxil Fumarate Release From Glutaraldehyde Cross-Linked Chitosan/Β-Cyclodextrin Hydrogel

Yaman,

Erdogan,

Taşdelen

2024

Hacettepe Journal of Biology and Chemistry

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“…Curcumin ((1E,6E)-1,7-bis(4-hydroksy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), Figure 1 , is a natural polyphenol isolated from the rhizome of the plant species Curcuma longa which shows numerous pharmacological activities by the modulation of physiological and biochemical processes. Research shows that curcumin possesses hypoglycemic [ 1 ], antimicrobial [ 2 ], hepatoprotective [ 3 ], anti-inflammatory [ 4 ], antioxidant [ 5 ], anticancer [ 6 ], antiviral [ 7 ] and many other effects. Various animal studies and clinical trials have shown that curcumin is safe to apply at high doses because it does not affect liver and kidney function.…”

Section: Introductionmentioning

confidence: 99%

The Formulation of Curcumin: 2-Hydroxypropyl-β-cyclodextrin Complex with Smart Hydrogel for Prolonged Release of Curcumin

et al. 2023

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Curcumin comes from the plant species Curcuma longa and shows numerous pharmacological activities. There are numerous curcumin formulations with gels or cyclodextrins in order to increase its solubility and bioavailability. This paper presents the formulation of complex of curcumin with 2-hydroxypropyl-β-cyclodextrin in a thermosensitive hydrogel, based on N-isopropylmethacrylamide and N-isopropylacrylamide with ethylene glycol dimethacrylate as a crosslinker. The product was characterized by chemical methods and also by FTIR, HPLC, DSC, SEM, XRD. The results show that synthesis was successfully done. With an increase in the quantity of crosslinker in the hydrogels, the starting release and the release rate of curcumin from the formulation of the complex with hydrogels decreases. The release rate of curcumin from the gel complex formulation is constant over time. It is possible to design a formulation that will release curcumin for more than 60 days. In order to determine the mechanism and kinetics of curcumin release, various mathematical models were applied by using the DDSolver package for Microsoft Excel application. The Korsmeyer-Peppas model best describes the release of curcumin from the gel formulation of the complex, while the values for the diffusion exponent (0.063–0.074) shows that mechanism of the release rate is based on diffusion.

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“…[15] Curcumin is a principal curcuminoid of turmeric, long believed to be bioactive components, isolated from natural Curcuma longa Linn. [16][17][18] Curcumin and its metabolites possess anti-inflammatory, [19,20] antioxidant, [21,22] antimicrobial, [23] and antiviral [24,25] activities. Further, in recent years, the literature reports that curcumin has beneficial effects in diseases of the neurological system, including AD.…”

Section: Introductionmentioning

confidence: 99%

A network pharmacology approach to identify the mechanisms and molecular targets of curcumin against Alzheimer disease

Wu¹,

Zheng²,

Tang³

et al. 2022

Medicine

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Background: Alzheimer disease (AD) is a degenerative brain disease, which may lead to severe memory loss and other cognitive disorders. However, few effective drugs are available in the clinic at present. Curcumin, a major ingredient of traditional Chinese medicine, Curcuma Longa, has various pharmacological activities. Therefore, exploring clinical drugs based on the inhibition of AD pathological features is imperative. Methods: First, we utilized the HERB database and Swisstarget Prediction database to get the related targets of curcumin and intersected with the AD targets. The intersection targets were used to construct the protein-protein interaction network and performed gene ontology and kyoto encyclopedia of genes and genomes analyses. Further, we obtained targets of curcumin against AD-related tau and aβ pathology via the AlzData database. These targets were applied to perform GEO and receiver operating characteristic analyses. Finally, the reliability of the core targets was evaluated using molecular docking technology. Results: We identified 49 targets of curcumin against AD, and kyoto encyclopedia of genes and genomes pathway enrichment analysis demonstrated that the Alzheimer disease pathway (has05010) was significantly enriched. Even more, we obtained 16 targets of curcumin-related Aβ and tau pathology. Among these targets, 8 targets involved the Alzheimer disease pathway and the biological process analyses showed that positive regulation of cytokine production (GO:0001819) was significantly enriched. Bioinformatic analyses indicated that HMOX1, CSF1R, NFKB1, GSK3B, BACE1, AR, or PTGS1 expression was significantly different compared to the control group in the AD patients. Finally, molecular docking studies suggested these genes have a good binding force with curcumin. Conclusions: In this study, we identified curcumin exerted the effect of treating AD by regulating multitargets and multichannels through the method of network pharmacology.

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Antiviral Activity of Chitosan Nanoparticles Encapsulating Curcumin Against Hepatitis C Virus Genotype 4a in Human Hepatoma Cell Lines [Retraction]

Cited by 4 publications

References 0 publications

Tenofovir Disoproxil Fumarate Release From Glutaraldehyde Cross-Linked Chitosan/Β-Cyclodextrin Hydrogel

Tenofovir Disoproxil Fumarate Release From Glutaraldehyde Cross-Linked Chitosan/Β-Cyclodextrin Hydrogel

The Formulation of Curcumin: 2-Hydroxypropyl-β-cyclodextrin Complex with Smart Hydrogel for Prolonged Release of Curcumin

A network pharmacology approach to identify the mechanisms and molecular targets of curcumin against Alzheimer disease

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