Antiviral Activity of Catechin against Dengue Virus Infection

Yi, Bin; Chew, Benjamin Xuan Zheng; Chen, Huixin; Lee, Regina Ching Hua; Fong, Yuhui Deborah; Chin, Wei-Xin; Mok, Chee Keng; Chu, Justin Jang Hann

doi:10.3390/v15061377

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…Meanwhile, catechin can inhibit NF-κB and FOXO3a by activating the AMPK/SIRT1 pathway, reducing the release of pro-inflammatory cytokines ( Cheng et al , 2019 ). Furthermore, a study conducted by Yi et al (2023) using in vitro approaches has demonstrated that catechin can inhibit the replication of DENV, particularly in the post-entry stages. In addition, it has been observed that catechin can reduce the titers of DENV-1, DENV-3, and DENV-4.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory effect of Faloak (Sterculia quadrifida R. Br) stem bark on TNF-α, IL-1β, and IL-6 in DENV-3-infected Wistar rats

Riwu,

Nugraha,

Triyono

et al. 2024

Open Vet J

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Background: Dengue infection can trigger an immunological response that results in an inflammatory reaction, which acts as a defensive mechanism to protect the host. Dengue infection leads to an elevation in the release of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6. These three cytokines have been shown to correlate with the development of thrombocytopenia and plasma leakage, which is related to the severity of the disease. Aim: This study aims to investigate the effect of faloak (Sterculia quadrifida R. Br) stem bark on TNF-α, IL-1β, and IL-6 levels in Wistar rats infected with dengue, specifically DENV-3. Methods: A group of 27 male Wistar rats (Rattus norvegicus) aged 2-3 months and weighting 200-300 grams were divided into three distinct groups: healthy, dengue, and treatment (dengue infection and extract) groups. The rats in both the dengue and treatment groups were administered an injection of DENV-3 with a titer of 105 pfu at a dosage of 0.8 cc via the intraperitoneal route. The propagation of DENV-3 was initiated using C6/36 cells, and it underwent four passages. The extract was administered orally via a nasogastric tube at a dosage of 1500mg/kg body weight once daily for seven days. The healthy group underwent blood sampling on the first day, whereas the dengue and therapy groups underwent blood sampling on the 5th and 8th, respectively. Results: Compared with the healthy group, TNF-α levels in the dengue and treatment groups showed significant differences on day five post-infection. The post hoc analysis revealed a statistically significant difference between the dengue-treatment and dengue-healthy groups. The IL-1β levels in the dengue and healthy groups significantly differed on days 5 and 8 post-infection compared to the healthy group. The treatment group had less of a decrease in IL-6 levels on days 5 and 8 than the dengue group. However, no statistically significant differences were observed. Conclusion: The stem bark of S. quadrifida shows potential as an anti-inflammatory agent in dengue infections, particularly in its ability to decrease levels of TNF-α and IL-1β.

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Section: Discussionmentioning

confidence: 99%

Anti-inflammatory effect of Faloak (Sterculia quadrifida R. Br) stem bark on TNF-α, IL-1β, and IL-6 in DENV-3-infected Wistar rats

Riwu,

Nugraha,

Triyono

et al. 2024

Open Vet J

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Hot Melt Extrusion Technology as a Modern Strategy for Improving the Bioavailability of Flavonoids

Danilova,

Gusev,

Maimistov

et al. 2024

Pharm Chem J

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The endoplasmic reticulum (ER): a crucial cellular hub in flavivirus infection and potential target site for antiviral interventions

Verhaegen,

Vermeire

2024

npj Viruses

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Dengue virus (DENV) is the most prevalent arthropod-borne flavivirus and imposes a significant healthcare threat worldwide. At present no FDA-approved specific antiviral treatment is available, and the safety of a vaccine against DENV is still on debate. Following its entry into the host cell, DENV takes advantage of the cellular secretory pathway to produce new infectious particles. The key organelle of the host cell in DENV infections is the endoplasmic reticulum (ER) which supports various stages throughout the entire life cycle of flaviviruses. This review delves into the intricate interplay between flaviviruses and the ER during their life cycle with a focus on the molecular mechanisms underlying viral replication, protein processing and virion assembly. Emphasizing the significance of the ER in the flavivirus life cycle, we highlight potential antiviral targets in ER-related steps during DENV replication and summarize the current antiviral drugs that are in (pre)clinical developmental stage. Insights into the exploitation of the ER by DENV offer promising avenues for the development of targeted antiviral strategies, providing a foundation for future research and therapeutic interventions against flaviviruses.

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Antiviral Activity of Catechin against Dengue Virus Infection

Cited by 3 publications

References 36 publications

Anti-inflammatory effect of Faloak (Sterculia quadrifida R. Br) stem bark on TNF-α, IL-1β, and IL-6 in DENV-3-infected Wistar rats

Anti-inflammatory effect of Faloak (Sterculia quadrifida R. Br) stem bark on TNF-α, IL-1β, and IL-6 in DENV-3-infected Wistar rats

Hot Melt Extrusion Technology as a Modern Strategy for Improving the Bioavailability of Flavonoids

The endoplasmic reticulum (ER): a crucial cellular hub in flavivirus infection and potential target site for antiviral interventions

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