RSC Adv.
 2023
DOI: 10.1039/d2ra06749h
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Antiviral activity of amide-appended α-hydroxytropolones against herpes simplex virus-1 and -2

Andreu Gazquez Casals
1
,
Alex J. Berkowitz
2
,
Alice J. Yu
3
et al.

Abstract: Amide-appended α-hydroxytropolones from a previously described library suppressed herpes simplex virus (HSV) replication in cell culture. A targeted follow-up library led to potent analogs against HSV-1 and -2, including acyclovir-resistant mutants.

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