2003
DOI: 10.1128/aac.47.6.1922-1928.2003
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Antiviral Activity and Pharmacokinetics of 1-(2,3-Dideoxy-2-Fluoro-β- l -Glyceropent-2-Enofuranosyl)Cytosine

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Cited by 10 publications
(15 citation statements)
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“…(Table 2), which is higher than other nucleoside RT inhibitors (2,3). Approximately 72% of the absorbed dose was recovered unchanged in the urine after oral administration in monkeys (CL R /CL T ).…”
Section: Discussionmentioning
confidence: 94%
“…(Table 2), which is higher than other nucleoside RT inhibitors (2,3). Approximately 72% of the absorbed dose was recovered unchanged in the urine after oral administration in monkeys (CL R /CL T ).…”
Section: Discussionmentioning
confidence: 94%
“…The areas under the concentration-time curve after oral dose (AUC oral ), maximum plasma concentration (C max ), time of maximum concentration (T max ), bioavailability, and apparent terminal phase half-life (t 1 12 and k 21 , first-order disposition rate constants between compartment 1 and compartment 2), which may otherwise be obscured by the oral absorption, and avoids reporting two sets of disposition rate constants for the same animal. However, this approach assumes that the intercompartment disposition rate constants remain consistent once the drug reaches the circulation (4,10). Initial estimates for model parameters were obtained by using parameters from similar compounds tested in rhesus monkeys (12).…”
Section: Methodsmentioning
confidence: 99%
“…The CL renal value was derived from a model fitted to the urine excretion data by using the pharmacokinetic parameters derived from the plasma data. The following equation was used: dX u /dt ϭ CL renal ϫ C p , where dX u is the rate of renal accumulation of compound during time interval dt, and C p is the predicted concentration of the drug in the plasma based on the plasma data coinciding with the urine collection interval (4). No weighting factor was used for the urine data.…”
Section: Methodsmentioning
confidence: 99%
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