Antiviral activity and Antioxidant role of phenolics from <em>Sophora interrupta</em> Bedd in NDV induced oxidative stress in chickens

Abstract

A b s t r a c tThe present investigation is taken up to evaluate the antiviral efficacy of phenolics isolated from during Newcastle disease virus (NDV) induced oxidative stress. The acti antioxidant enzymes such as superoxide dismutase (SOD), catalyse (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione were significantly decreased in brain and lung tissues of N causing oxidative stress. In addition, histopathological alterations disclosed that lungs of NDV infected chicken were affected severely as evidenced by the alterations in alveolar cell morphology, congestion, necrotic and cells, neuronal necrosis, degeneration in myelin sheath and compression of cells were observed in the brain of NDV infected chickens. These reduced antioxidant defence mechanisms and histopathological pre Bw/day for one week. Pre also caused treatment with the phenolics isolated from antiviral activity and thus the plant extract may be used as a prophylactic treatment prevention of NDV infection in chicken.