Antiviral activity against porcine epidemic diarrhea virus of Pogostemon cablin polysaccharide

Chen, Yun; Luo, Qiyuan; Li, Shanman; Li, Chengheng; Liao, Suya; Yang, Xin; Zhou, Ruigang; Zhu, Yongjian; Teng, Ling; Chen, Huricha; Yang, Yuhui

doi:10.1016/j.jep.2020.113009

Cited by 26 publications

(22 citation statements)

References 40 publications

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“…Besides, previous literature highlighted the multimodal biological functions viz . antimicrobial, [23] antiviral, [24] antioxidant, [25] insecticidal [26] etc. Recently, EO of the plant has been studied for bacterial biofilm inhibitory activities [27] …”

Section: Introductionmentioning

confidence: 99%

Nematicidal and Molecular Docking Investigation of Essential Oils from Pogostemon cablin Ecotypes against Meloidogyne incognita

Keerthiraj

Mandal

Rao

et al. 2021

Chemistry & Biodiversity

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Root‐knot nematode, Meloidogyne incognita is one of the most destructive nematodes worldwide. Essential oils (EOs) are being extensively utilized as eco‐benign bionematicides, although the precise mechanism of action remains unclear. Pogostemon cablin Benth. is well‐known as “Patchouli”. It is native to South East Asia and known for ethno‐pharmacological properties. In this study, chemical composition and potential nematicidal effect of EOs hydrodistilled from the leaves of P. cablin grown at three different locations in India were comprehensively investigated to correlate their mechanism of action for target specific binding affinities toward nematode proteins. Aromatic volatile Pogostemon essential oils (PEO) from Northern India (PEO‐NI), Southern India (PEO‐SI) and North Eastern India (PEO‐NEI) were analyzed by Gas Chromatography‐Mass Spectrometry (GC/MS) to characterize forty volatile compounds. Maximum thirty‐three components were identified in PEO‐NEI. Sesquiterpenes were predominant with higher content of α‐guaiene (2.3–24.4 %), patchoulol (6.1–32.7 %) and α‐bulnesene (5.9–27.1 %). Patchoulol was the major component in PEO‐SI (32.7±1.2 %) and PEO‐NEI (29.2±1.1 %), while α‐guaiene in PEO‐NI (24.4±1.2 %). In vitro nematicidal assay revealed significant nematicidal action (LC50 44.6–87.0 μg mL−1) against juveniles of M. incognita within 24 h exposure. Mortality increases with increasing time to 48 h (LC50 33.6–71.6 μg mL−1) and 72 h (LC50 27.7–61.2 μg mL−1). Molecular modelling and in silico studies revealed multi‐modal inhibitive action of α‐bulnesene (−22 to −13 kJ mol−1) and α‐guaiene (−22 to −12 kJ mol−1) against three target proteins namely, acetyl cholinesterase (AChE), odorant response gene‐1 (ODR1), odorant response gene‐3 (ODR3). Most preferable binding mechanism was observed against AChE due to pi‐alkyl, pi‐sigma, and hydrophobic interactions. Structure nematicidal activity relationship suggested the presence of hydroxy group for nematicidal activity is nonessential, rather highly depends on synergistic composition of sesquiterpene hydrocarbons.

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Section: Introductionmentioning

confidence: 99%

Nematicidal and Molecular Docking Investigation of Essential Oils from Pogostemon cablin Ecotypes against Meloidogyne incognita

Keerthiraj

Mandal

Rao

et al. 2021

Chemistry & Biodiversity

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“…They found that the extract inhibited cell viability, clonal growth, and induced cell apoptosis in a dose-dependent manner. This effect was exerted by silencing the PI3K/AKT/mTOR signaling pathway, which is associated with upregulation of cleaved PARP, cleaved caspase 3/7/8/9, caspase 3/7/8/9, Bax, and downregulation of PI3K, P-PI3K, PARP, AKT,P-AKT, mTOR, and P-mTOR and Bcl-2 (Ao et al 2019 ; Cao and He 2020 ; Chen et al 2020d ). Compounds 246 and 249 had direct killing effects on various tumor cells, such as HepG2, BEL-7402, and SGC-7901, and could inhibit the invasion and metastasis of gastric cancer last cells (Huang et al 2018c ; Elberry et al 2020 ; Zhang et al 2020a ).…”

Section: Biological Effectsmentioning

confidence: 99%

“…Compound ( 29 ) also inhibited rotavirus-induced cytopathic effects, probably due to its ability to modulate the rotavirus replication and toll-like receptor 3-mediated inflammatory pathways. This chalcone inhibited the adsorption and replication of reoviruses (human type 1–3 reoviruses and Korean porcine reovirus), by inhibiting viral RNA, protein synthesis, hemagglutination, and shedding (Boozari et al 2019b ; Chen et al 2020d ). Many flavonoids, including 6 isoflavones and three pterocarpans, isolated from S. davidii flowers have reported to exhibit protective effects against Tobacco Mosaic virus replication with a higher inhibition rate than ningnanmycin as a positive control (Wang et al 2018d ; Yang et al 2019 ).…”

Section: Biological Effectsmentioning

confidence: 99%

“…Genistein ( 120 ) and biochanin A ( 130 ) showed about 2.5–6.5 folds greater inhibitory effects on arachidonic acid and U46619 induced platelet aggregation. Irisolidone ( 132 ) was ∼22–40 folds stronger inhibitor than acetylsalicylic acid on arachidonic acid and U46619 induced aggregation (Kim and Yun-Choi, 2008 ; Chen et al 2020d ).…”

Section: Biological Effectsmentioning

confidence: 99%

“…Three isoflavones: genistein ( 120 ), biochanin A ( 130 ) and irisolidone ( 132 ); and four were identified as isoflavone-glycosides: sissotrin ( 117 ), tectoridin 118 , genistin ( 119 ), and sophorabioside ( 134 ) from the stems, fruits and leaves of S. japonica (Kim and Yun-Choi 2008 ; Chen et al 2020d ). The isoflavone-glycoside tectoridin 118 showed inhibitory activity on U46619 and arachidonic acid-induced aggregation (IC 50 of 123.4 and 25.9 µM, respectively) which had an activity similar to that of genistein ( 120 ) and biochanin A ( 130 ), but less than that of irisolidone ( 132 ) (Kim and Yun-Choi 2008 ; Chen et al 2020d ).…”

Section: Biological Effectsmentioning

confidence: 99%

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Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives

2021

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Sophora is deemed as one of the most remarkable genera of Fabaceae, and the third largest family of flowering plants. The genus Sophora comprises approximately 52 species, 19 varieties, and 7 forms that are widely distributed in Asia and mildly in Africa. Sophora species are recognized to be substantial sources of broad spectrum biopertinent secondary metabolites namely flavonoids, isoflavonoids, chalcones, chromones, pterocarpans, coumarins, benzofuran derivatives, sterols, saponins (mainly triterpene glycosides), oligostilbenes, and mainly alkaloids. Meanwhile, extracts and isolated compounds from Sophora have been identified to possess several health-promising effects including anti-inflammatory, anti-arthritic, antiplatelets, antipyretic, anticancer, antiviral, antimicrobial, antioxidant, anti-osteoporosis, anti-ulcerative colitis, antidiabetic, anti-obesity, antidiarrheal, and insecticidal activities. Herein, the present review aims to provide comprehensive details about the phytochemicals and biological effects of Sophora species. The review spotlighted on the promising phytonutrients extracted from Sophora and their plethora of bioactivities. The review also clarifies the remaining gaps and thus qualifies and supplies a platform for further investigations of these compounds.

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Relationship among Chinese herb polysaccharide (CHP), gut microbiota, and chronic diarrhea and impact of CHP on chronic diarrhea

Xue,

Mei,

Wang

et al. 2023

Food Science & Nutrition

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Chronic diarrhea, including diarrhea‐predominant irritable bowel syndrome (IBS‐D), osmotic diarrhea, bile acid diarrhea, and antibiotic‐associated diarrhea, is a common problem which is highly associated with disorders of the gut microbiota composition such as small intestinal bacterial overgrowth (SIBO) and so on. A growing number of studies have supported the view that Chinese herbal formula alleviates the symptoms of diarrhea by modulating the fecal microbiota. Chinese herbal polysaccharides (CHPs) are natural polymers composed of monosaccharides that are widely found in Chinese herbs and function as important active ingredients. Commensal gut microbiota has an extensive capacity to utilize CHPs and play a vital role in degrading polysaccharides into short‐chain fatty acids (SCFAs). Many CHPs, as prebiotics, have an antidiarrheal role to promote the growth of beneficial bacteria and inhibit the colonization of pathogenic bacteria. This review systematically summarizes the relationship among gut microbiota, chronic diarrhea, and CHPs as well as recent progress on the impacts of CHPs on the gut microbiota and recent advances on the possible role of CHPs in chronic diarrhea.

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Antiviral activity against porcine epidemic diarrhea virus of Pogostemon cablin polysaccharide

Cited by 26 publications

References 40 publications

Nematicidal and Molecular Docking Investigation of Essential Oils from Pogostemon cablin Ecotypes against Meloidogyne incognita

Nematicidal and Molecular Docking Investigation of Essential Oils from Pogostemon cablin Ecotypes against Meloidogyne incognita

Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives

Relationship among Chinese herb polysaccharide (CHP), gut microbiota, and chronic diarrhea and impact of CHP on chronic diarrhea

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