Antiviral activities of some Ethiopian medicinal plants used for the treatment of dermatological disorders

Gebre‐Mariam, Tsige; Neubert, Reinhard H.H.; Schmidt, Peter; Wutzler, Peter; Schmidtke, Michaela

doi:10.1016/j.jep.2005.08.071

Cited by 79 publications

(54 citation statements)

References 26 publications

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“…The extracts were filtered and concentrated using a rota-vapour at 50°C and 100 mbar. Further preparation was done according to Gebre-Mariam et al (2006). The yields of the methanol extracts were between 1.6% and 8.4%.…”

Section: Methodsmentioning

confidence: 99%

Screening of some kenyan medicinal plants for antibacterial activity

Wagate

Mbaria

Gakuya

et al. 2009

Phytotherapy Research

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Eleven medicinal plants used by traditional healers in Machakos and Kitui District were screened, namely: Ajuga remota Benth, Aloe secundiflora Engl, Amaranthus hybridus L, Cassia didymobotrya Fes, Croton macrostachyus Del, Entada leptostachya Harms, Erythrina abyssinica DC, Harrisonia abyssinica Oliv, Schkuhria pinnata O. Ktze, Terminalia kilimandscharica Engl and Ziziphus abyssinica Hochst for potential antibacterial activity against four medically important bacterial strains, namely: Bacillus cereus ATCC 11778, Escherichia coli ATCC 25922, Micrococcus lutea ATCC 9341 and Pseudomonas aeruginosa ATCC 27853. The antibacterial activity of methanol extracts was determined as the minimum inhibitory concentration (MIC). The plant extracts were more active against Gram-positive (G+) than Gram-negative (G-) bacteria. The positive controls were streptomycin and benzylpenicillin for G- and G+ bacteria, respectively, both had a significant MIC at <1 mg/mL. The most susceptible bacteria were B. cereus, followed by M. lutea, while the most resistant bacteria were Ps. aeruginosa, followed by E. coli. The present study supports the use of these plants by the herbalists in the management of bacterial ailments. H. abyssinica and T. kilimandscharica showed the best antibacterial activity; hence these plants can be further subjected to phytochemical and pharmacological evaluation.

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Section: Methodsmentioning

confidence: 99%

Screening of some kenyan medicinal plants for antibacterial activity

Wagate

Mbaria

Gakuya

et al. 2009

Phytotherapy Research

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“…The use of plants as medicine has been attributed to the presence of bioactive components such as flavanoids, alkaloids, saponins and tannins (Evans, 2002;Farnsworth, 1994). Several studies have confirmed antiviral activities of medicinal plants (Rajbhandari et al, 2001;Gebre-Mariam et al, 2006;Qiao-feng et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Documentation of indigenous knowledge on medicinal plants used to manage common influenza and related symptoms in Luwero district, central Uganda

Katuura¹,

Omujal²,

Tumusiime³

et al. 2016

J. Med. Plants Res.

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Herbs are used in treatment of various diseases in Uganda. Influenza is one of the diseases that is treated by herbs, the disease previously known to be non fatal is progressively becoming a threat due to immune complications in people living with HIV, poor diets and the fear of fatal introduced strains like Bird Flu. An ethno botanical survey was conducted to document medicinal plants and preparations used in the management of influenza and related symptoms in Luwero, Central Uganda. Information was obtained using questionnaires, focus group discussions, key informant interviews, direct observations in households and field excursions. Information on plants/parts used, method of preparation, mode of administration, commonly used formulations and their dosages was documented. Twenty nine medicinal plants distributed in 17 families were documented; Mangifera indica family Anacardiaceae, Ocimum basilicum L., (Lamiaceae), Psidium guajava L. (Mytaceae) and Mormodica feotida L. (Curcubitaceae) were the commonly used plants respectively. The leaves were the most used part of the plants while decoctions were the commonly used method of preparation and the oral route was the main mode of administration. Antimicrobial assay and nutritional profile of some formulae is underway to standardize formulae that can be used against respiratory infections at household level.

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“…The extracts were filtered and concentrated using rota vapor at 50°C and 100 mbar. Further preparation was done according to Gebre-Mariam et al (2006). The lyophilized extracts were kept at +4°C until they were screened.…”

mentioning

confidence: 99%

Antibacterial and cytotoxic activity of Kenyan medicinal plants

Cyrus¹,

Daniel

Nanyingi³

et al. 2008

Mem. Inst. Oswaldo Cruz

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(Miaron et al. 2004, Kareru et al. 2007, Njoroge & Bussman 2007. The high cost of imported conventional drugs and/or inaccessibility to western health care facilities has led to overreliance on traditional medicine since it is affordable and available to rural people. On the other hand, even when western health facilities are available, traditional medicine is viewed as an efficient and an acceptable system from a cultural perspective (Munguti 1997, Miaron et al. 2004.Infections associated with bacterial pathogens are among some of the indications treated using traditional remedies in Kenya (Njoroge & Bussman 2007). Bacterial infections are prevalent due to various factors such as the HIV/AIDS pandemic, poor hygiene, overcrowding and resistance to convectional antimicrobials. Natural products of higher plants may provide a new source of antimicrobial agents with possibly novel mechanisms of action (Adenisa et al. 2000).The aim of this study was to screen methanolic medicinal plant extracts traditionally used for the management of infectious diseases in Kenya. Brine shrimp (Artemia salina Leach) lethality test (BSLA) was used to systematically evaluate the cytotoxic effects of extracts. Broth dilution assays using Gram-negative bacteria Escherichia coli (ATCC 25922) and Pseudomonas aerugenosa (ATCC 27853) and Gram-positive bacteria Staphylococcus aureus (ATCC25923) and Bacillus cereus (ATCC 11778) was utilized to obtain the minimal inhibitory concentrations (MIC) of the plant extracts. MATERIALS AND METHODSPlant materials -Plants were collected during dry season from January-March 2006 in Machakos and Kitui areas of the Eastern province, Kenya, based on ethnopharmacological use through interviews with traditional health practitioners. The plants were identified by Mr. Ochung, a plant taxonomist, and voucher specimens (Table I) were deposited at the Department of Land Resource Management and Agricultural Technology Herbarium, University of Nairobi.Extraction -The plant parts (whole plant, bark, root, leaves, tubers or a mixture) were chopped into small pieces, air dried at rt (25°C) under shade and pulverized using a laboratory mill yielding 300-400 g. The fine powders were separately soaked in 70% methanol (3 × 500 mL) for four days at rt to produce extracts. The extracts were filtered and concentrated using rota vapor at 50°C and 100 mbar. Further preparation was done according to Gebre-Mariam et al. (2006). The lyophilized extracts were kept at +4°C until they were screened. The yields of the methanol extracts were between 5%-8.4%. The methanolic extract yields were obtained as follows: leaves of Ajuga remota Benth (320 g) yielded 7.5%, leaves of Amaranthus hybridus L. (350 g) yielded 4.2%, leaves of Cassia didymobotrya Fres. (320 g) yielded 8.4%, a mixture of leaves and roots of Croton macrostachyus Del. (400 g) yielded 5.2%, tubers of Entada leptostachya Harms (300 g) yielded 6%, mixture of leaves and bark of Harrisonia abyssinica Oliv (360 g) yielded 6.5% and bark of Terminalia kilimandscharica Engl. (370...

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Antiviral activities of some Ethiopian medicinal plants used for the treatment of dermatological disorders

Cited by 79 publications

References 26 publications

Screening of some kenyan medicinal plants for antibacterial activity

Screening of some kenyan medicinal plants for antibacterial activity

Documentation of indigenous knowledge on medicinal plants used to manage common influenza and related symptoms in Luwero district, central Uganda

Antibacterial and cytotoxic activity of Kenyan medicinal plants

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