Antiviral Activities of Heated Dolomite Powder

Powders of cerium (Ce)-substituted and tungsten (W)-substituted La 2 Mo 2 O 9 (LMO) were prepared using polymerizable complex method. Their antiviral and antibacterial performances were then evaluated using bacteriophage Qβ, bacteriophage Φ6, Escherichia coli , and Staphylococcus aureus . The obtained powders, which were almost single-phase, exhibited both antiviral and antibacterial properties. Effects of dissolved ions on their antiviral activity against bacteriophage Qβ were remarkable. A certain contribution of direct contact to the powder surface was also inferred along with the dissolved ion effect for antiviral activity against bacteriophage Φ6. Dissolved ion effects and pH values suggest that both Mo and W are in the form of polyacids. Antiviral activity against bacteriophage Φ6 was improved by substituting Ce for La in LMO. Similarly to LMO, Ce-substituted LMO exhibited hydrophobicity. Inactivation of alkaline phosphatase enzyme proteins was inferred as one mechanism of the antiviral and antibacterial activities of the obtained powders.

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“…TiO 2 [ 4 , 5 ]), and other materials (e.g. ZnO and CaO [ 6 , 7 ]). In fact, some of these materials have already been applied for practical use.…”

Section: Introductionmentioning

confidence: 99%

Effects of cerium and tungsten substitution on antiviral and antibacterial properties of lanthanum molybdate

Matsumoto

Sunada²,

Nagai³

et al. 2020

Materials Science and Engineering: C

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“…Yamana et al [ 27] reported that heated and hydrated dolomite (CaMg(CO 3 ) 2 ) had antiviral activity against avian and human influenza, avian infectious bronchitis, Newcastle disease virus and avian laryngotracheitis viruses. The investigation of Motoike et al [ 28,29] showed that MgO and CaO produced by thermal decomposition were responsible for this strong antiviral activity. Motoike et al [28] indicated that MgO had a stronger anti-influenza activity than Mg(OH) 2 .…”

Section: Discussionmentioning

confidence: 99%

In vitro anti‐foot‐and‐mouth disease virus activity of magnesium oxide nanoparticles

Rafiei

Rezatofighi

Ardakani

et al. 2015

IET nanobiotechnol.

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Foot-and-mouth disease (FMD) is an extremely contagious viral disease of cloven-hoofed animals that can lead to huge economic losses in the livestock production. No antiviral therapies are available for treating FMD virus (FMDV) infections in animals. The antiviral effects of magnesium oxide nanoparticles (MgO NPs) on the FMDV were investigated in cell culture. The viability of the cells after MgO NP treatment was determined using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay. The direct effects of MgO NPs on the FMDV in extracellular (virucidal assay) and also different stages of virus replication (antiviral assay) were evaluated by plaque reduction assay. The results showed that MgO NPs were safe at concentrations up to 250 µg/ml in the Razi Bovine kidney cell line. The treatments with NPs indicated that the MgO NPs exerted in vitro virucidal and antiviral activities. Plaque reduction assay revealed that MgO NPs can inhibit FMDV by more than 90% at the early stages of infection such as attachment and penetration but not after penetration. The results of this study suggested that NPs might be applied locally as an antiviral agent in early stages of infection in susceptible animals.

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“…Moreover, polyethylene and polyvinyl chloride mixed with HDP was also reported to exhibit antimicrobial activity, and this result was put into practical use Wiedemann, 1987. Yamana et al 2007and Motoike et al 2008 reported that HDP showed strong antiviral activity against H3N2 human influenza virus and H5N3 avian influenza virus. Therefore, dolomite is expected to be useful for inhibiting the incidence of infectious diseases.…”

Section: Chemiluminescence Analysismentioning

confidence: 99%

Sporicidal Characteristics of Heated Dolomite Powder against Bacillus subtilis Spores

et al. 2014

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Antiviral Activities of Heated Dolomite Powder

Cited by 23 publications

References 14 publications

Effects of cerium and tungsten substitution on antiviral and antibacterial properties of lanthanum molybdate

Effects of cerium and tungsten substitution on antiviral and antibacterial properties of lanthanum molybdate

In vitro anti‐foot‐and‐mouth disease virus activity of magnesium oxide nanoparticles

Sporicidal Characteristics of Heated Dolomite Powder against Bacillus subtilis Spores

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