Antiviral activities of glycyrrhizin and its modified compounds against human immunodeficiency virus type 1(HIV-1) and herpes simplex virus type 1(HSV-1) in vitro.

Hirabayashi, Kazuhiro; Iwata, Susumu; Matsumoto, Hisakazu; Mori, Takeo; Shibata, Shoji; Baba, Masanori; Ito, Masahiko; Shigeta, Shirô; Nakashima, Hideki; Yamamoto, Naoki

doi:10.1248/cpb.39.112

Cited by 92 publications

(65 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has in-vitro and in-vivo antiviral activity, interfering with DNA and RNA replication of a wide range of viruses, including herpes, influenza A and B, hepatitis B, coronavirus, and SARS (Pompei, et al, 1979;Hirabayashi et al, 1991;Badam, 1994;Lin, 2003;Hoever, et al 2005;Lee, et al, 2007). This pharmaceutical preparation has also been demonstrated to be able to prevent the virion from hatching from its capsid (Pompei, et al, 1979;Lin, 2003), apparently due to a dose-dependent inhibition of kinase-P phosphorylation (Chavali, et al, 1987;Ohtsuki and Ishida, 1988).…”

Section: Introductionmentioning

confidence: 99%

Effects of Glycyrrhizic Acid on Productive and Immune Parameters of Broilers

Ocampo

Gómez-Verduzco

Tapia-Pérez

et al. 2016

Rev. Bras. Cienc. Avic.

View full text Add to dashboard Cite

KeywordsBroiler chickens, growth promotion, immune system, glycyrrhizic acid.Submitted: February/2015 Approved: March/2016 ABSTRACT Considering that glycyrrhizic acid (GRA) has been shown to have in-vitro and in-vivo antiviral activity against a wide range of viruses as well as immunostimulating activity, a trial to evaluate its effects on the performance and the immune response against Newcastle disease of broiler chickens was carried out. The study was performed with oneday-old Ross x Ross broiler chickens. GRA was added to the drinking water throughout the 49-d production cycle at a dose of 0.03%. Sample size of the trial was established in a pilot assay. Results showed that broiler chickens treated with GRA presented better weight gain, final body weight, feed conversion ratio, and lower mortality rate than the non-treated controls. In addition, GRA-treated birds presented higher antibody titers against Newcastle disease virus and more efficient cellular immune response, as demonstrated by the late-hypersensitivity response test. Blood lymphocyte and thrombocyte counts also increased in this group. The histopathological examination of the bursa, spleen, and thymus revealed that only the thymus of the GRA-treated group had a clearly defined increase in cortex thickness on day 49. The bursa showed a higher number of lymphoid lesions in CG on days 21 and 49 compared with the GRA group. These results suggest that GRA has growth promotion properties, which are possibly linked to immunebased effects.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of Glycyrrhizic Acid on Productive and Immune Parameters of Broilers

Ocampo

Gómez-Verduzco

Tapia-Pérez

et al. 2016

Rev. Bras. Cienc. Avic.

View full text Add to dashboard Cite

show abstract

“…In order to confirm these activities, many studies concerning the constituents of these plants have been conducted. This has led to the isolation of several compounds with anti-HIV activity, such as glycyrrhizin (Mori et al, 1990;Hirabayashi et al, 1991;Badam, 1994), hypericin (Farnet et al, 1998;Gulick et al, 1999), and several polysaccharides (Gollapudi et al, 1995;Nakano et al, 1997), lectins (Balzarini et al, 1992), polyphenols (Hashimoto et al, 1996) and diterpenes (Paris et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

Screening of selected plant extracts for in vitro inhibitory activity on Human Immunodeficiency Virus

Bedoya

Palomino

Abad

et al. 2002

Phytotherapy Research

View full text Add to dashboard Cite

As part of our screening of anti-AIDS agents from natural sources, extracts of 15 medicinal plants widely used in the folk medicines of North America and Europe were evaluated in vitro. Most of the extracts tested were relatively nontoxic to human lymphocytic MT-2 cells, but only the extracts of Hysopp officinalis and Dittrichia viscosa exhibited anti-HIV activity in an in vitro MTT assay. The 50% hydroalcohol extract of Hysopp officinalis and the aqueous extract of Dittrichia viscosa showed inhibitory effects against HIV-1 induced infections in MT-2 cells at concentrations ranging from 50 to 100 microg/mL and 25 to 400 microg/mL, respectively. Both extracts showed no appreciable cytotoxicity at these concentrations.

show abstract

“…12 Glycyrrhizic acid has been shown to possess in vitro and in vivo antiviral activity interfering with both DNA and RNA replication. [9][10][11][12][13] As in this trial, other authors have also proposed antiviral activity for glycyrrhizic acid. 8,[10][11][12]14 However, the precise manner in which this action is achieved is not known.…”

Section: Original Researchmentioning

confidence: 99%

“…8 It is already available in the human market, and it is commercialized as a nutraceutical preparation mixed with antioxidants, vitamins and oligoelements (Viusid®, from Catalysis, Spain; distributed by Dermaceutical México, SA de CV Mexico City). Glycyrrhizic acid has been shown to possess in vitro and in vivo antiviral activity that interferes with both DNA and RNA replication, thus interfering with the replication of a wide range of viruses, including herpes, influenza A and B, hepatitis B, coronavirus and SARS [9][10][11][12][13][14] Glycyrrhizic acid and derivatives have been shown to be able to impede the release of virions from their capsids, 14 apparently due to a dose-dependent inhibition of protein kinase P phosphorylation 15,16 and perhaps due to its ability to decrease membrane fluidity. 8 Likewise, glycyrrhizic acid interferes with arylamine N-acetyltransferase activity in bacteria, thus showing antibacterial effects against at least Streptococcus spp., Haemophilus spp., and Klebsiella spp.…”

Section: Introductionmentioning

confidence: 99%

Effects of glycyrrhizic acid (Viusid-Vet® powder) on the reduction of influenza virus spread and on production parameters in pigs

Ocampo-Camberos¹,

Tapia²,

Gutiérrez³

et al. 2017

Vet Méx OA

View full text Add to dashboard Cite

Influenza viruses are among the most important respiratory pathogens in pigs and humans. They cause seasonal epidemics in pigs and occasional pandemics in humans. Herbal remedies have been regarded as suitable elements to aid in controlling influenza. This study was carried out to analyse the effects of the in-feed administration of glycyrrhizic acid, the best-known component of liquorice (as Viusid-Vet® powder), in pigs suffering an outbreak of influenza. Eighty crossbred Duroc-Landrace pigs, one day post-weaning (22 days old), were included in this trial. Piglets were randomly divided into the following two groups: those treated with glycyrrhizic acid and an untreated control group. Serological measurements to assess viral load and humoral responses were carried out. Blood samples from pigs were obtained every fortnight, starting on week two and ending on week 15. With these samples, haemagglutination inhibition (HI) tests were performed, using A/swine/New Jersey/11/76 (H1N1) and A/swine/Minnesota/9088-2/98 (H3N2) as reference viruses. Quantitative RT-PCR tests against the M gene of the influenza virus were also performed to assess viral shedding from nasal swab samples on weeks 1 to 8 after the beginning of the trial. Weight variables were assessed weekly for 18 weeks. In the HI tests, treated animals showed fewer positive responses compared to the control group for H1N1 and H3N2. However, a positive response to viral protection, as assessed by HI tests, was regarded as not conclusive of humoral immune stimulation. qRT-PCR tests for viral spread exhibited a lower rate of excretion for the treated group compared to the untreated one. Hence, it appears that glycyrrhizic acid stimulates, to some extent, immune responses against pig influenza as measured by viral shedding. For mean body weight, the generalized estimating equations show a higher weight gain for pigs treated with glycyrrhizic acid than the control group (P = 0.0001). These effects may assist producers in addressing the aftermath of an influenza outbreak.

show abstract

Antiviral activities of glycyrrhizin and its modified compounds against human immunodeficiency virus type 1(HIV-1) and herpes simplex virus type 1(HSV-1) in vitro.

Cited by 92 publications

References 0 publications

Effects of Glycyrrhizic Acid on Productive and Immune Parameters of Broilers

Effects of Glycyrrhizic Acid on Productive and Immune Parameters of Broilers

Screening of selected plant extracts for in vitro inhibitory activity on Human Immunodeficiency Virus

Effects of glycyrrhizic acid (Viusid-Vet® powder) on the reduction of influenza virus spread and on production parameters in pigs

Contact Info

Product

Resources

About