Antiviral activities of atractylon from Atractylodis Rhizoma

Abstract

Atractylodis Rhizoma is a traditional medicinal herb, which has antibacterial, antiviral, anti-inflammatory and anti-allergic, anticancer, gastroprotective and neuroprotective activities. It is widely used for treating fever, cold, phlegm, edema and arthralgia syndrome in South-East Asian nations. In this study, 6 chemical compositions of Atractylodis Rhizoma were characterized by spectral analysis and their antiviral activities were evaluated in vitro and in vivo. Among them, atractylon showed most significant antiviral activities. Atractylon treatment at doses of 10–40 mg/kg for 5 days attenuated influenza A virus (IAV)-induced pulmonary injury and decreased the serum levels of interleukin (IL)-6, tumor necrosis factor-α and IL-1β, but increased interferon-β (IFN-β) levels. Atractylon treatment upregulated the expression of Toll-like receptor 7 (TLR7), MyD88, tumor necrosis factor receptor-associated factor 6 and IFN-β mRNA but downregulated nuclear factor-κB p65 protein expression in the lung tissues of IAV-infected mice. These results demonstrated that atractylon significantly alleviated IAV-induced lung injury via regulating the TLR7 signaling pathway, and may warrant further evaluation as a possible agent for IAV treatment.

Attractylone attenuates sepsis‐associated encephalopathy and cognitive dysfunction by inhibiting microglial activation and neuroinflammation

“…This herb is mainly distributed in the region of East China such as Jiangsu, Henan, Shanxi, and Shanxi provinces and has been used as crude extracts/decoctions or as a component in various herbal formulations for centuries. 12,13 This compound exhibits various pharmacological effects, including antiviral, antiinflammatory, hepatoprotective, and anticancer properties. 14 However, it remains unclear whether Atr has a protective effect on SAE and cognitive dysfunction.…”

Qualitative and quantitative determination of Atractylodes rhizome using ultra‐performance liquid chromatography coupled with linear ion trap–Orbitrap mass spectrometry with data‐dependent processing

“…Atractylodin (63) is a characteristic component of A. lancea and A. chinensis , but was hardly detectable in A. koreana . In previous research, atractylon (69) was reported to be the characteristic component in A. koreana , and occurred at a higher concentration than in A. lancea and A. chinensis (Chen et al, ; Cheng, Mai, Hou, Ping, & Chen, ). Atractylenolide I (43), atractylenolide II (49) and atractylenolide III (53) were the degradation products of atractylon, which would explain the co‐occurrence of these chemical components in the characteristic compounds list (Li et al, ; Song et al, ; Yan et al, ).…”

Using UPLC-MS/MS for Characterization of Active Components in Extracts of Yupingfeng and Application to a Comparative Pharmacokinetic Study in Rat Plasma after Oral Administration

“…After 33 chemical constituents were identified in the extract of YPF, seven major constituents were chosen to further investigate the pharmacokinetic behavior of YPF formula: astragaloside, calycosin and formononetin in Astragali radix ; atractylenolide II in Atractylodes rhizoma ; and cimicifugoside, 4- O -beta- d -glucosyl-5- O -methylvisamminol, and sec- O -glucosylhamaudol in Saposhnikoviae radix . In early literature, some pharmacological studies [ 26 , 27 , 28 , 29 , 30 , 31 ] have proven that these seven constituents are the main active compounds in the corresponding individual herbs, leading to changes of overall therapeutic effects, and they show remarkable anti-inflammatory, antiviral and immunosuppressive activities. Therefore, we assume that these constituents could explain the effectiveness of YPF formula.…”