Abstract:Numerous structural analogues of 3‐amino‐4‐hydroxy‐ω‐methylaminoacetophenone were tested for their effect on the multiplication of influenza virus (FM1 strain) in embryonated eggs, infected via the allantoic cavity. Antiviral activity was found in ω‐aminoacetophenones containing an amino and hydroxyl group in the aromatic nucleus in the ortho or para positions to each other. The most powerful antiviral activity was found in the series of ω‐alkylamino‐5‐amino‐2: 4‐dihydroxyacetophenones. Derivatives of acetophe… Show more
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