Antivenom Activity of Traditional Herbal Drugs: An Update

Lakshmi, V.; Lakshmi, T

doi:10.7897/2230-8407.04901

Cited by 20 publications

(6 citation statements)

References 7 publications

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“…Because of side effects or adverse events (e.g., anaphylactic reactions), serum sickness and sometimes the anti-venom itself produces complications during treatment. 22 …”

Section: Snake Venom and Snake Anti-venomsmentioning

confidence: 99%

Infrequent use of medicinal plants from India in snakebite treatment

Upasani¹,

Upasani

Beldar

et al. 2018

Integrative Medicine Research

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Snakes have fascinated humankind for millennia. Snakebites are a serious medical, social, and economic problem that are experienced worldwide; however, they are most serious in tropical and subtropical countries. The reasons for this are 1) the presence of more species of the most dangerous snakes, 2) the inaccessibility of immediate medical treatment, and 3) poor health care. The goal of this study was to collect information concerning rare, less utilized, and less studied medicinal plants. More than 100 plants were found to have potential to be utilized as anti-snake venom across India. Data accumulated from a variety of literature sources revealed useful plant families, the parts of plants used, and how to utilize them. In India, there are over 520 plant species, belonging to approximately 122 families, which could be useful in the management of snakebites. This study was conducted to encourage researchers to create herbal antidotes, which will counteract snake venom. These may prove to be an inexpensive and easily assessable alternative, which would be of immense importance to society. Plants from families such as Acanthaceae, Arecaceae, Apocynaceae, Caesalpiniaceae, Asteraceae, Cucurbitaceae, Fabaceae, Euphorbiaceae, Lamiaceae, Rubiaceae, and Zingiberaceae are the most useful. In India, experts of folklore are using herbs either single or in combination with others.

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“…Because of side effects or adverse events (e.g., anaphylactic reactions), serum sickness and sometimes the anti-venom itself produces complications during treatment. 22 …”

Section: Snake Venom and Snake Anti-venomsmentioning

confidence: 99%

Infrequent use of medicinal plants from India in snakebite treatment

Upasani¹,

Upasani

Beldar

et al. 2018

Integrative Medicine Research

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“…The raw extracts or chemical constituents might be used for treatment of various human diseases [7]. Reactive oxygen species are considered as a major contributor to age-related symptoms and pathogenesis of many diseases.…”

Section: Introductionmentioning

confidence: 99%

Tyrosinase inhibition and antioxidant properties of Asphodelus microcarpus extracts

Petrillo

González-Paramás

Era

et al. 2016

BMC Complement Altern Med

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Background Asphodelus microcarpus belongs to the family Liliaceae that include several medicinal plants. In the traditional medicine plants of the genus Asphodelus are used to treat skin disorders such as ectodermal parasites, psoriasis, microbial infection and for lightening freckles. In order to find novel skin depigmenting agents, the present work was carry out to evaluate antioxidant activity and tyrosinase inhibitory potential of leaves, flowers and tubers extracts of A. microcarpus. The phytochemical composition of the active extract was also evaluated.MethodsThree different extracts (water, methanol and ethanol) from leaves, flowers and tubers of A. microcarpus were evaluated for their inhibitory effect on tyrosinase activity using l-3,4-dihydroxyphenylalanine (l-DOPA) as substrate. Inhibition of cellular tyrosinase activity and melanin production was also investigated in melanoma B16F10 cells. Antioxidant activity, total phenolic and flavonoids contents were determined using standard in vitro methods. HPLC-DAD-MS was used to identify phenolic profile of the active extract.ResultsThe results showed that all extracts have a direct inhibitory anti-tyrosinase activity, with ethanolic extract from flowers (FEE) exhibiting the stronger effect. Kinetic analysis revealed that FEE acts as an uncompetitive inhibitor with a Ki value of 0.19 mg/mL. The same effect was observed in murine melanoma B16F10 cells. Cellular tyrosinase activity as well as melanin content were reduced in FEE-treated cells. The results were comparable to that of the standard tyrosinase inhibitor (kojic acid). Furthermore, the same extract showed the highest antioxidant activity and an elevated levels of total phenolics and flavonoid content. Eleven phenolic components were identified as chlorogenic acid, luteolin derivates, naringenin and apigenin.ConclusionsOur findings showed that FEE from A. microcarpus inhibits tyrosinase and exerted antimelanogenesis effect in B16F10 cells. This extract also showed the highest scavenging activity, which could be mainly attributed to its high levels of total polyphenols and flavonoids. These results suggest that A. microcarpus has a great potential as sources of bioactive compounds which could be used as depigmenting agents in skin disorders.

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“…Many species were used in folk and human medicine, because they have been recognized to have medicinal properties and beneficial impact on health, e.g. antioxidant activity, digestive stimulation action, antiinflammatory, antimicrobial, hypolipidemic, antimutagenic effects and anticarcinogenic potential [1,6,9,14]. Moreover, calendula has healing and antiseptic properties with actions that are sudorific and analgesic, affect the bile duct, are antiinflammatory, antiviral and anti-emetic, and tone the skin with vasodilation [15].…”

Section: Introductionmentioning

confidence: 99%

“…Yarrow (Achillea millefolium L.) also traditionally has been used as an abortifacient, emmenagogue, contraceptive, and for stimulating uterine contractions. For this reason, it is contra-indicated for use in pregnancy [14].…”

Section: Introductionmentioning

confidence: 99%

Herbal teas as a rich source of phenolic compounds

Augspole¹,

Dūma²,

Cinkmanis³

et al. 2018

chemija

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Phenolic compounds are of a considerable interest and have received more and more attention in recent years due to their bioactive functions. These components are known as secondary plant metabolites and also possess antimicrobial, antiviral and anti-inflammatory properties. The popular Latvian herbals – Calendula (Calendula officinalis L.), Lady’s-mantle (Alchemilla vulgaris L.), Yarrow (Achillea millefolium L.), Peppermint (Mentha × piperita L.) and Bellis (Bellis perennis L.) – are widely used for herbal teas. The objective of this study was to determine individual phenolic compounds in herbal infusions using high-performance liquid chromatography. The obtained results showed significant differences (p ˂ 0.05) of the phenolics content in the analysed herbal teas. The total content of the identified 14 phenolic compounds in Yarrow tea was on the average 136.76 ± 0.8 mg 100 g–1, in Peppermint tea 304.38 ± 10.7 mg 100 g–1, in Lady’s-mantle tea 319.53 ± 12.5 mg 100 g–1, in Calendula tea 586.36 ± 17.6 mg 100 g–1, but in Bellis tea it was 802.96 ± 21.3 mg 100 g–1. The dominant phenolic compound in Peppermint, Lady’s-mantle and Yarrow teas was rutin, but chlorogenic acid in Bellis tea. Calendula tea has an abundant quantity of sinapic acid.

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Antivenom Activity of Traditional Herbal Drugs: An Update

Cited by 20 publications

References 7 publications

Infrequent use of medicinal plants from India in snakebite treatment

Infrequent use of medicinal plants from India in snakebite treatment

Tyrosinase inhibition and antioxidant properties of Asphodelus microcarpus extracts

Herbal teas as a rich source of phenolic compounds

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