Antivascular effects of electrochemotherapy: implications in treatment of bleeding metastases

Electroporation: characteristics and therapeutic application of the method (a review)

“…Антиваскулярный эффект электрохимиотерапии используется при лечении метастазов меланомы: в 70-80% случаев наблюдалась необратимая реакция [53].…”

Elektrokemoterapija – Učinkovita Metoda Zdravljenja Tumorjev S Kombinacijo Kemoterapevtika in Električnega Polja

“…59 Vazokonstrikcija, ki je prehodnega značaja, povzroči začasen zastoj pretoka krvi v tumorju in s tem daljšo prisotnost kemoterapevtika znotraj tumorja, kar poveča učinek njegovega delovanje.60 Kemoterapevtik je potrebno vnesti v žilni sistem tumorja pred dovajanjem električnih pulzov; vazokonstrikcija bi namreč lahko onemogočila učin-kovit vnos njegovih molekul v tumor, če bi ga vnesli šele po elektroporaciji. 61 Pomemben mehanizem delovanja je tudi imunski odziv organizma po elektrokemoterapiji. Elektrokemoterapija ne učinkuje na vse celice, ki se nahajajo v tumorju, enako.…”

Electrochemotherapy: A New Arm against Cancer

“…ECT has been reported as highly effective, with complete response rates between 60 and 70% and objective response rates of about 80% [4]. The treatment is safe, repeatable, associated with minimal discomfort for patients, limited toxicity and short duration of hospital stay.…”

“…These kinds of lesions can be very stress full for the patients, often aggravate by ulceration and pain. ECT can play a role in the local management of these neoplastic lesions, because electroporation of the cell membrane causes significant vascular changes in the tumor region, inducing arteriolar vasoconstriction with the reduction of tissue blood perfusion and short-term cessation of bleeding and ulcerated cutaneous lesions [4].Another application of ECT is the possibility to use the procedure as neoadjuvant treatment, in order to reduce tumor burden before surgical resection [2].The European standard operating procedure for ECT calls attention to the technical aspects of the procedure and have established this treatment in clinical practice [5,6].ECT has been reported as highly effective, with complete response rates between 60 and 70% and objective response rates of about 80% [4]. The treatment is safe, repeatable, associated with minimal discomfort for patients, limited toxicity and short duration of hospital stay.…”

“…These kinds of lesions can be very stress full for the patients, often aggravate by ulceration and pain. ECT can play a role in the local management of these neoplastic lesions, because electroporation of the cell membrane causes significant vascular changes in the tumor region, inducing arteriolar vasoconstriction with the reduction of tissue blood perfusion and short-term cessation of bleeding and ulcerated cutaneous lesions [4].…”