Antiulcerogenic effects of two Maytenus species in laboratory animals

Formigoni, Maria Lúcia Oliveira de Souza; Oliveira, Maria Gabriela Menezes; Monteiro, Maristela; Silveira-Filho, Nylson G. Da; Bráz, Sandra; Carlini, E. A.

doi:10.1016/0378-8741(91)90185-g

Cited by 110 publications

(73 citation statements)

References 10 publications

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“…Maytenus ilicifolia has been widely studies, and its medicinal effects have been well demonstrated. [20][21][22][23][24] Mattei and Carlini11 found that the extract of Maytenus ilicifolia has a significant in vitro antioxidant effect;…”

Section: Discussionmentioning

confidence: 99%

O uso de Maytenus ilicifolia na prevenção da ototoxicidade induzida pela cisplatina

Kasse

Cruz

Iha

et al. 2008

Rev. Bras. Otorrinolaringol.

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Mayt enus ilicifolia is a native plant from South America, with several medicinal properties including antioxidant effects. Aim: using an original cisplatin induced ototoxicity model, we evaluated a possible otoprotection caused by Maytenus ilicifolia extract. Materials and methods: clinical and experimental study design with female albino guinea pigs divided in groups as follows: 9 animals receiving cisplatin only (three doses of 7.5mg/kg/day), 4 animals receiving the plant extract only, 10 animals receiving the cisplatin protocol and 1g/kg/day of extract for 8 days, 5 animals with cisplatin and 3g/kg/day of extract for 8 days, and 5 animals receiving extract for 3 weeks and cisplatin in the last week. The tests were distortion product otoacoustic emissions, brainstem auditory response, before and after medication and scanning electron microscopy. Results: the animals receiving cisplatin plus plant extract, had alterations in all the tests, showing lesions on the basal cochlear region under electron microscopy. Conclusions: Despite of the plant extract's antioxidant effect, it was not sufficient to protect the cochlea against cisplatin ototoxicity.

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Section: Discussionmentioning

confidence: 99%

O uso de Maytenus ilicifolia na prevenção da ototoxicidade induzida pela cisplatina

Kasse

Cruz

Iha

et al. 2008

Rev. Bras. Otorrinolaringol.

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“…Austroplenckia populnea was selected for this work based not only on the previous published work on antiulcer activity (Seito, 2002), but also because it belongs to the Celastraceae family, from which Maytenus ilicifolia stands out as a commercial phytotherapeutic for the treatment of gastric ulcer (Souza-Formigoni et al, 1991). Moreover, it was found that the triterpenes are the major compounds responsible for the M. ilicifolia antiulcer activity (Vilegas and Lanças, 1994).…”

Section: Discussionmentioning

confidence: 99%

Antiulcerogenic Activity of Crude Extract, Fractions and Populnoic Acid Isolated from Austroplenckia populnea (Celastraceae)

Andrade

Antoniolli

Comunello

et al. 2006

Zeitschrift Für Naturforschung C

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Many plant crude extracts and their isolated compounds are the most attractive sources of new drugs and show promising results for the treatment of gastric ulcers. Austroplenckia populnea is commonly known as "marmelinho-do campo, mangabeira-brava, mangabarana and vime" and it has been used in folk medicine as anti-dysenteric and anti-rheumatic. Powdered bark wood (3.25 kg) was macerated with aqueous ethanol (96%) and the extract was concentrated under reduced pressure to yield 406 g of crude hydralcoholic extract. The hydralcoholic extract was suspended in aqueous methanol and partitioned with hexane, chloroform and ethyl acetate (EtOAc) in sequence, yielding 8.0 g, 9.5 g and 98.17 g of crude extracts, respectively. Chromatography of the hexane extract over a silica gel column led to the isolation of the triterpene populnoic acid. The oral administration of hydralcoholic, hexane, chloroform and EtOAc extracts (200 mg/kg) decreased the ulcer lesion index (ULI) by 83.15%, 46.87%, 32.2%, 68.12%, respectively. Oral administration of populnoic acid (100 mg/ kg) diminished the ULI by 55.29%. All the obtained results were significant in comparison with the negative control, with exception of the chloroform extract.

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“…Studies performed with M. ilicifolia leaves extracts pointed its anti ulcerogenic (Carlini and Braz, 1998;Souza-Formigoni and Oliveira, 1991;Niero et al, 2001), analgesic , antitumoral (Fox, 1991), and abortive (Montanari and Bevilacqua, 2002) properties.…”

Section: Introductionmentioning

confidence: 99%

Intra and inter populational genetic variability in Maytenus ilicifolia Mart. ex Reiss. 1861, through RAPD markers

et al. 2007

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Maytenus ilicifolia is a medicinal plant largely used in the South Brazilian folk medicine. The aim of this study was to quantify the intra and inter populational genetic variability in three populations of M. ilicifolia, focusing on the genetic conservation of this species, which has been threatened by anthropic action. RAPD (Random Amplified Polymorphic DNA) markers were used to analyze 30 plants of each of the three populations collected in the Alto Uruguai Gaúcho region. Fourteen selected primers generated a total of 158 bands, 71.5% of which were polymorphic. The comparison of Jaccard's distances showed that the intra populational variation was higher than the inter populational variability, and cluster analysis allowed the separation of the three populations. Just 7.6% of the bands were specific of at least two populations. Data indicate that the analyzed M. ilicifolia populations represent a single genetic pool, and therefore any of the population thoroughly can represent the overall genetic variability of the species in the sampled region.Keywords: conservation, espinheira santa, native populations, molecular markers. Variabilidade genética intra e interpopulacional em Maytenus ilicifolia Mart. ex Reiss, utilizando marcadores RAPD ResumoMaytenus ilicifolia é uma planta medicinal bastante utilizada na medicina popular da região sul do Brasil. O objetivo deste estudo foi quantificar a variabilidade genética intra e interpopulacional em três populações de M. ilicifolia visando a conservação genética desta espécie, que se encontra ameaçada pela ação antrópica. Marcadores RAPD (Random Amplified Polymorphic DNA) foram utilizados para analisar 30 plantas de cada uma das três populações coletadas na região do Alto Uruguai Gaúcho. Foram selecionados 14 primers, que geraram 158 bandas, das quais 71,5% foram polimórficas. A comparação das distâncias de Jaccard mostraram que a variabilidade intra populacional foi maior que a interpopulacional, e a análise de agrupamentos permitiu a separação das três populações. Somente 7.6% das bandas foram específicas de pelo menos duas populações. Os resultados indicam que as populações de M. ilicifolia analisadas representam um único conjunto gênico, de tal forma que qualquer uma das populações pode representar a variabilidade genética geral da espécie na região.

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Antiulcerogenic effects of two Maytenus species in laboratory animals

Cited by 110 publications

References 10 publications

O uso de Maytenus ilicifolia na prevenção da ototoxicidade induzida pela cisplatina

O uso de Maytenus ilicifolia na prevenção da ototoxicidade induzida pela cisplatina

Antiulcerogenic Activity of Crude Extract, Fractions and Populnoic Acid Isolated from Austroplenckia populnea (Celastraceae)

Intra and inter populational genetic variability in Maytenus ilicifolia Mart. ex Reiss. 1861, through RAPD markers

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