Antiulcerogenic effect and cytotoxic activity of semi-synthetic crotonin obtained from Croton cajucara Benth.

Gastroprotective and ulcer-healing activity of oleanolic acid derivatives: In vitro–in vivo relationships

“…Different natural or semi-synthetic terpenes with reported gastroprotective activity have demonstrated to increase the gastric prostaglandin content (Lewis and Hanson, 1991;Farina et al, 1998;Matsuda et al, 2002;Albino de Almeida et al, 2003;Rodríguez et al, 2005). Acetylation of the free OH at C-3 in oleanolic acid reduced the effect on PGE 2 content as can be seen in compound 2.…”

Gastroprotective effect and cytotoxicity of terpenes from the Paraguayan crude drug “yagua rova” (Jatropha isabelli)

“…Some Euphorbiaceae diterpenes isolated from medicinal plants have proved to be powerful gastroprotective agents. Of particular interest are the clerodanes from the Brazilian Croton cajucara including trans-dehydrocrotonin (DHC) (Souza-Brito et al, 1998;Hiruma-Lima et al, 1999;Rodríguez et al, 2004) trans-crotonin (Hiruma-Lima et al, 2002), crotonin (Albino de Almeida et al, 2003) and DHC derivatives . Other Euphorbiaceae diterpenes studied in Brazil included cordatin (Hiruma-Lima et al, 2000) and aparisthman from Aparisthmium cordatum (Hiruma-Lima et al, 2001).…”

“…A study on the gastroprotective effect of cyperenoic acid, a terpenoid constituents of "yagua rova" and its semisynthetic derivatives was carried out by Pertino et al (2006). Some Euphorbiaceae diterpenes isolated from plants traditionally used to treat gastric lesions including transdehydrocrotonin (DHC) (Souza-Brito et al, 1998;Hiruma-Lima et al, 1999;Rodríguez et al, 2004), DHC derivatives , trans-crotonin (Hiruma-Lima et al, 2002), crotonin (Albino de Almeida et al, 2003), cordatin (Hiruma-Lima et al, 2000) and aparisthman from Aparisthmium cordatum (Hiruma-Lima et al, 2001) have been reported as powerful gastroprotective agents. Other terpenoids obtained from plants used in traditional medicine and presenting good gastroprotective effect include sesquiterpene lactones, poligodial, triterpenes and carbenoxolone from Glycyrrhiza glabra (Schmeda-Hirschmann and Yesilada, 2005).…”

Traditional medicine and gastroprotective crude drugs

“…Some structure-activity relationships of C. cajucara diterpenes have been published by Melo et al (2003). Crotonin, another diterpene from C. cajucara and its derivatives inhibited induced gastric lesions in animals by 80% when administered at 100 mg/kg (Albino de Almeida et al, 2003).…”