Antiulcerogenic activity of bark extract of Tabebuia avellanedae, Lorentz ex Griseb

Twardowschy, André; Freitas, Cristina Setim; Baggio, Cristiane Hatsuko; Mayer, Bárbara; Santos, Ana Cristina dos; Pizzolatti, Moacir Geraldo; Zacarias, Aline Alvarez; Santos, Élide Pereira dos; Otuki, Michel Fleith; Marques, Maria Consuelo Andrade

doi:10.1016/j.jep.2008.05.013

Cited by 30 publications

(9 citation statements)

References 22 publications

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“…inhibitory effect on the production of nitric oxide and prostaglandin E2 (Awale et al, 2005;Byeon et al, 2008). Additionally, other pharmacological properties including anti-ulcerogenic activity and anticarcinogenic activity have been reported (Moon et al, 2010;Twardowschy et al, 2008). However, there are only a few studies concerning on the antioxidant properties of Tabebuia constituents.…”

Section: Discussionmentioning

confidence: 99%

Antioxidative activity of taheebo (Tabebuia impetiginosa Martius ex DC.) extracts on the H2O2-induced NIH3T3 cells

Lee¹,

Park²,

Yum³

2012

J. Med. Plants Res.

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The antioxidant activities of Tabebuia impetiginosa methanolic extract (TIME) were examined with its serial solvent extracts using hexane, chloroform and ethyl acetate against hydrogen peroxide (H 2 O 2)induced oxidative stress in NIH3T3 cells. The three serial extracts were selected for the study of regeneration on antioxidant enzyme activities because butanol and water extracts significantly affected cell survival. Treatment of hydrogen peroxide on the cells showed a dramatic repression on superoxide dismutase (SOD) and cytosolic NADPH +-dependent isocitrate dehydrogenase (IDPc) activities with the remaining activities of 56.1 and 37.5%, respectively. The three extracts significantly regenerated SOD activity with the range of 103 to 178% when compared to the control, and IDPc activity with the range of 34.4 to 42.2%. The three extracts also regenerated catalase and glucose-6-phosphate dehydrogenase activities with the range of 91.6 to 139% in comparison to the control. Hydrogen peroxide did not change intracellular glutathione content. The three serial extracts of TIME enhanced intracellular glutathione concentration, protected proteins from the oxidative attack by H 2 O 2 and also decreased malonaldehyde formation in the cells. Taken together, the non-polar extracts of TIME protect NIH3T3 cells from the H 2 O 2-induced oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Antioxidative activity of taheebo (Tabebuia impetiginosa Martius ex DC.) extracts on the H2O2-induced NIH3T3 cells

Lee¹,

Park²,

Yum³

2012

J. Med. Plants Res.

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“…The stem bark of "lapacho" (Tabebuia spp., Bignoniaceae) and the rhizomes of "yagua rova" (Jatropha isabelii, Euphorbiaceae) are used in Paraguayan traditional medicine as crude drugs to treat gastric lesions and as anti-inflammatory agents [1][2][3][4]. The naphthoquinones from Tabebuia and the terpenes from J. isabelii, including cyperenoic acid, display gastroprotective activity in vivo, thereby supporting the ethnobotanical information.…”

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confidence: 81%

Potential Gastroprotective Effect of Novel Cyperenoic Acid/Quinone Derivatives in Human Cell Cultures

et al. 2012

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The stem bark of Tabebuia species and the rhizomes of Jatropha isabelii are used in Paraguayan traditional medicine to treat gastric lesions and as anti-inflammatory agents. The sesquiterpene cyperenoic acid obtained from J. isabelii has been shown to display a gastroprotective effect in animal models of induced gastric ulcers while the quinone lapachol shows several biological effects associated with the use of the crude drug. The aim of this work was to prepare hybrid molecules presenting a terpene and a quinone moiety and to obtain an assessment of the gastroprotective activity of the new compounds using human cell cultures (MRC-5 fibroblasts and AGS epithelial gastric cells). Eight compounds, including the natural products and semisynthetic derivatives were assessed for proliferation of MRC-5 fibroblasts, protection against sodium taurocholate-induced damage, prostaglandin E2 content, and stimulation of cellular-reduced glutathione synthesis in AGS cells. The following antioxidant assays were performed: DPPH discoloration, scavenging of the superoxide anion, and inhibition of induced lipoperoxidation in erythrocyte membranes. 3-Hydroxy-β-lapachone (3) and cyperenoic acid (4) stimulated fibroblast proliferation. Lapachol (1), dihydroprenyl lapachol (2), 3-hydroxy-β-lapachone (3), and lapachoyl cyperenate (6) protected against sodium taurocholate-induced damage in AGS cells. Lapachol (1) and dihydroprenyl lapachoyl cyperenate (7) significantly stimulated prostaglandin E2 synthesis in AGS cells. Compounds 3, 4, and 7 raised reduced glutathione levels in AGS cells. The hybrid compounds presented activities different than those of the starting sesquiterpene or quinones.

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“…This activity has been previously reported by Nagata et al (1998). Not only do Tabebuia avellanedae innerbark compounds exert a direct effect on Helicobacter pylori but their ethanol extracts also have a direct protective effect on the gastric mucosa by inducing mucus production (Twardowschy et al 2008). …”

Section: Antibacterial Activitymentioning

confidence: 99%

Anti-infectious activity in plants of the genus Tabebuia

2013

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Infectious diseases are a worldwide public health problem. There is growing research in the field of new plant-based drugs for treating such diseases. Our objective was to perform a systematic literature review to evaluate the anti-infectious activity (antibacterial, antifungal, antiviral and antiparasitic) attributed to plants of the Tabebuia (Bignoniaceae) genus. We conducted a search for the period of 2000-2013 in ScienceDirect, Scopus, PubMed, Embase, Napralert and SciELO databases using the following MeSH terms: Tabebuia, biological activity, bioactive compounds, chemical compounds, diseases, traditional medicine, tropical infections, infections and treatment. We found ethnobotanical and experimental (in vitro) evidence supporting the use of Tabebuia species for treating infectious diseases. In addition, the compounds responsible for their antimicrobial activity have been isolated, and their structures have been elucidated, emphasizing among them naphthoquinones such as lapachol. Natural products isolated from Tabebuia plants may be an alternative for developing new anti-infectious agents.

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Antiulcerogenic activity of bark extract of Tabebuia avellanedae, Lorentz ex Griseb

Cited by 30 publications

References 22 publications

Antioxidative activity of taheebo (Tabebuia impetiginosa Martius ex DC.) extracts on the H2O2-induced NIH3T3 cells

Antioxidative activity of taheebo (Tabebuia impetiginosa Martius ex DC.) extracts on the H2O2-induced NIH3T3 cells

Potential Gastroprotective Effect of Novel Cyperenoic Acid/Quinone Derivatives in Human Cell Cultures

Anti-infectious activity in plants of the genus Tabebuia

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