Antiulcer Effects of Alpha Lipoic Acid on Gastric Acid Secretion and Mucosal Defense Factors in Rats

El-kader, Marwa Abd; Ali, M. Ayub; El-Sammad, Nermin M.; El-Shaer, Marwa A.

doi:10.3923/ajb.2011.426.438

Cited by 4 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies implicated that gastric acid secretion also acts an aggressive factor that caused serious mucosal damage in long term NSAIDtreatment (Bindu et al, 2020;Sinha et al, 2013). Notably, it has been demonstrated that ALA decreased gastric acid secretion, increased gastric pH and mucus secretion to protect the gastric wall from NSAID-induced damage (Abd El-Kader et al, 2011). From this point of view, it can be predicted that ALA may have protective effects in gastric damage induced by NSAIDs due to its combined free radical scavenging properties and its effect on gastric acid secretion (Gomaa et al, 2018;Navari-Izzo et al, 2002;Şehirli et al, 2008).…”

Section: Mucosal Erosionmentioning

confidence: 99%

Alpha‐lipoic acid: A promising adjuvant for nonsteroidal anti‐inflammatory drugs therapy with improved efficacy and gastroprotection

Barut

Engin

Sayğın

et al. 2021

Drug Development Research

View full text Add to dashboard Cite

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in a wide variety of diseases due to their analgesic and anti-inflammatory effects, but their usage have been limited due to significant ulcerogenic side effects. In the present study, we aimed to evaluate the effect of α-lipoic acid (ALA) treatment on the anti-inflammatory activity of indomethacin (Indo) as well as the possible therapeutic effect of ALA on high dose Indo-induced gastropathy in female mice. Mice were treated with Indo (5 or 30 mg/kg, p.o) alone or in combination with ALA (50, 100 or 200 mg/kg, i.p). in vivo anti-inflammatory effect was evaluated by formalin-induced paw edema measured as paw thickness and edema. Gastric damage was evaluated macroscopically and histologically by scoring mucosal hemorrhage, erosion, edema and inflammation.

show abstract

Section: Mucosal Erosionmentioning

confidence: 99%

Alpha‐lipoic acid: A promising adjuvant for nonsteroidal anti‐inflammatory drugs therapy with improved efficacy and gastroprotection

Barut

Engin

Sayğın

et al. 2021

Drug Development Research

View full text Add to dashboard Cite

show abstract

“…This is in agreement with the earlier work carried out by [25], who reported that gastric mucus secretion increased in the gastric mucosa of animals pre-treated with monosodium glutamate (MSG).Goel and Bhattachaya reported that an increase in the gastric mucus secretion in stomach prevents physical damage and back diffusion of hydrogen ions [26]. Similarly, the work of Abd El-kader et al using alpha lipoic acid (ALA) revealed that the gastric mucosa was protected from injury through increasing the mucus in the stomach wall [27]. Naturally, the body produces free radicals as byproducts (of metabolism) which can cause damage.…”

Section: Discussionmentioning

confidence: 99%

Anti-ulcer Mechanisms of L-lysine in Male Wistar Rats

Okonkwo

Oluwole

Dare

2017

JALSI

View full text Add to dashboard Cite

L-lysine is an essential amino acid found in most protein food sources, in particular high-protein foods such as eggs, meat, soybean, milk and fish. This amino acid has been reported to have an indirect antioxidant property. Antioxidants are known to have gastroprotective property. This study examined the effect of L-lysine pre-treatment on indomethacin induced ulceration in male Wistar rats. Fifty male Wistar rats were used for this study and were randomly divided into two study groups of twenty five (25) animals each. The first subgroup was used for the anti-ulcer studies; antioxidant enzymes (SOD, CAT, and MDA), Nitric oxide, parietal cell count, and the mean ulcer score, while the second subgroup was used for the gastric mucus secretion study. Each subgroup was divided into five groups with five animals per group namely: Control, Omeprazole (20 mg/kg), L-lysine (100 mg/kg, 200 mg/kg and 400 mg/kg). The results showed that l-lysine pre-treatment significantly increased SOD activity and reduced MDA levels but with no significant change in catalase activity. NO levels in the treated groups were significantly higher than in the control. Gastric mucus secretion was significantly increased and the Original Research Article

show abstract