Antiulcer activity of dehydroabietic acid derivatives.

Wada, Hiroshi; Kodato, Shinichi; Kawamori, Masatoshi; Morikawa, T.; Nakai, Hideo; Takeda, Mikio; Saito, Seiichi; Onoda, Yuichi; Tamaki, Hiroyuki

doi:10.1248/cpb.33.1472

Cited by 61 publications

(31 citation statements)

References 2 publications

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“…defensive factors (22,44). Ecabet improves the efficacy of antibiotic therapy for H. pylori-infected patients with peptic ulcer (1,16) and has been suggested to exert unknown anti-H. pylori actions besides inhibition of urease activity (1,16).…”

Section: Discussionmentioning

confidence: 99%

Ecabet sodium inhibitsHelicobacter pylorilipopolysaccharide-induced activation of NADPH oxidase 1 or apoptosis of guinea pig gastric mucosal cells

Kusumoto

Kawahara

Kuwano

et al. 2005

American Journal of Physiology-Gastrointestinal and Liver Physi

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Section: Discussionmentioning

confidence: 99%

Ecabet sodium inhibitsHelicobacter pylorilipopolysaccharide-induced activation of NADPH oxidase 1 or apoptosis of guinea pig gastric mucosal cells

Kusumoto

Kawahara

Kuwano

et al. 2005

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…In extensive research aimed at the develop ment of a new anti-ulcer agent, we found that some derivatives of dehydroabietic acid ex hibited antisecretory and/or antipepsin ac tivity (1 ). A preliminary experiment revealed that among these compounds, 12-sulfodehy droabietic acid monosodium salt (TA-271 1, Fig.…”

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confidence: 99%

Effects of 12-sulfodehydroabietic acid monosodium salt (TA-2711), a new anti-ulcer agent, on gastric secretion and experimental ulcers in rats.

1989

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Abstract-Effects of 12-sulfodehydroabietic acid monosodium salt (TA-2711), a new anti-ulcer agent, on gastric secretion and experimental ulcers were investigated in rats. Oral administration of TA-2711 at doses of 25 to 100 mg/kg immediately after pyloric ligation markedly reduced pepsin activity and slightly lowered acid concentration without affecting the volume of gastric juice. Addition of TA-2711 (0.25-16 mg/ml) directly to gastric juice also reduced pepsin activity in vitro. Oral TA-2711 dose-relatedly inhibited the formation of pylorus-ligated ulcers (50-200 mg/kg), aspirin-induced gastric erosions (25-100 mg/kg) and cysteamine-induced duodenal ulcers (100-800 mg/kg). In addition, this drug prevented both the formation of gastric lesions (6.3-100 mg/kg, p.o.) and the fall in gastric potential difference (100 mg/kg, p.o.) induced by ethanol. The preventive effect against ethanol-induced lesions was suppressed by pretreatment with indomethacin (10 mg/kg, s.c.). Intravenous dosing of TA-2711 (10-100 mg/kg) never produced such effects on ethanol-induced lesions and pepsin activity as observed by oral administration. These results indicate that TA-2711 exerts its anti-ulcer effect by a local action, and it is suggested that both reduction of pepsin activity and a mucosal prostaglandin-mediated process are involved in the anti-ulcer action of TA-271 1.

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“…Dehydroabietic acid is the dominant component of disproportionated rosin produced by catalytic disproportionation of rosin. Wide applications of dehydroabietic acid can be expected in the field of synthetic chemicals due to its unique characteristics such as stable properties, strong antioxidant ability and large specific rotatory power [2][3][4][5]. In recent years, in order to prepare rosin-based functional compounds with high additional value, people have paid more attention to the modification of dehydroabietic acid.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of methyl 12-benzoyldehydroabietate in ionic liquid

Duan

Huang

et al. 2008

Front. Chem. China

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In the presence of the ionic liquid [bmim]Br/ AlCl 3 as green reaction medium, methyl 12-benzoyldehydroabietate was synthesized through Friedel-Crafts acylation reactions on the aromatic ring of methyl dehydroabietate. The optimum synthetic conditions of the target product were found to be as follows: molar ratio of methyl dehydroabietate to [bmim]Br to AlCl 3 to benzoyl chloride 1:4:8:8, reaction temperature 40uC, reaction time 2 h. The target product was analyzed and characterized by means of IR, MS, NMR and elemental analysis. The results show that this novel method has the advantages of mild condition, short reaction time and environmental benignity.

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Antiulcer activity of dehydroabietic acid derivatives.

Cited by 61 publications

References 2 publications

Ecabet sodium inhibitsHelicobacter pylorilipopolysaccharide-induced activation of NADPH oxidase 1 or apoptosis of guinea pig gastric mucosal cells

Ecabet sodium inhibitsHelicobacter pylorilipopolysaccharide-induced activation of NADPH oxidase 1 or apoptosis of guinea pig gastric mucosal cells

Effects of 12-sulfodehydroabietic acid monosodium salt (TA-2711), a new anti-ulcer agent, on gastric secretion and experimental ulcers in rats.

Synthesis of methyl 12-benzoyldehydroabietate in ionic liquid

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