Antitussive Activity of the Water-Extracted Carbohydrate Polymer from<i>Terminalia chebula</i>on Citric Acid-Induced Cough

Nosálóvá, G; Jurecek, Ludovit; Chatterjee, Udipta R.; Majee, Sujay Kumar; Nosál, S; Ray, Bimalendu

doi:10.1155/2013/650134

Cited by 19 publications

(10 citation statements)

References 37 publications

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“… 35 The sugars present in triphala include arabinose, galactose, xylose, glucose, mannose, rhamnose, galacturonic acid, and arabinogalactan. 36 , 37 The specific sugars and sugar linkages present in each herbal medicine ultimately dictate which species are able to catabolize and, therefore, metabolize herb glycan components as an energy source.…”

Section: Discussionmentioning

confidence: 99%

Prebiotic Potential of Herbal Medicines Used in Digestive Health and Disease

Peterson

Sharma

Uchitel

et al. 2018

The Journal of Alternative and Complementary Medicine

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Introduction: The prebiotic potential of herbal medicines has been scarcely studied.Methods: The authors therefore used anaerobic human fecal cultivation to investigate whether three herbal medicines commonly used in gastrointestinal health and disease in Ayurveda alter the growth and abundance of specific bacterial species.Results: Profiling of cultures supplemented with Glycyrrhiza glabra, Ulmus rubra, or triphala formulation by 16S rDNA sequencing revealed profound changes in diverse taxa in human gut microbiota. Principal coordinate analysis highlights that each herbal medicine drives the formation of unique microbial communities. The relative abundance of approximately one-third of the 299 species profiled was altered by all 3 medicines, whereas additional species displayed herb-specific alterations. Herb supplementation increased the abundance of many bacteria known to promote human health, including Bifidobacterium spp., Lactobacillus spp., and Bacteroides spp. Herb supplementation resulted in the reduced relative abundance of many species, including potential pathogens such as Citrobacter freundii and Klebsiella pneumoniae. Herbal medicines induced blooms of butyrate- and propionate-producing species. U. rubra and triphala significantly increased the relative abundance of butyrate-producing bacteria, whereas G. glabra induced the largest increase in propionate-producing species. To achieve greater insight into the mechanisms through which herbal medicines alter microbial communities, the authors assessed the shifts in abundance of glycosyl hydrolase families induced by each herbal medicine. Herb supplementation, particularly G. glabra, significantly increased the representation and potential expression of several glycosyl hydrolase families.Discussion: These studies are novel in highlighting the significant prebiotic potential of medicinal herbs and suggest that the health benefits of these herbs are due, at least in part, to their ability to modulate the gut microbiota in a manner predicted to improve colonic epithelium function, reduce inflammation, and protect from opportunistic infection. Forthcoming studies in human clinical trials will test the concordance of the results generated in vitro and the predictions made by genome analyses.

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Section: Discussionmentioning

confidence: 99%

Prebiotic Potential of Herbal Medicines Used in Digestive Health and Disease

Peterson

Sharma

Uchitel

et al. 2018

The Journal of Alternative and Complementary Medicine

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“…The biological activity of other types of medicinal mushroom, in particular the immunomodulatory activity, has been associated with the HMW polysaccharide or polysaccharide–protein complex found in the mushroom extract ( Tzianabos, 2000 ; El Enshasy and Hatti-Kaul, 2013 ). Oral application of a polysaccharide fraction with a highly branched arabinogalactan protein derived from a medicinal plant, Terminalia chebula , displayed antitussive properties in TRIK strain guinea pigs ( Nosalova et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Airway Relaxation Effects of Water-Soluble Sclerotial Extract From Lignosus rhinocerotis

Lee

Yap

et al. 2018

Front. Pharmacol.

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Lignosus rhinocerotis has a long history of use by the indigenous community within East Asia to treat a range of health conditions including asthma and chronic cough. To date, there is limited scientific evidence to support its therapeutic effects in relieving these airways conditions. In this study, we examined the effects of the different molecular weight fractions [high-molecular-weight (HMW), medium-molecular-weight (MMW), and low-molecular-weight (LMW)] obtained from the cold water sclerotial extract (CWE) of L. rhinocerotis on airways patency using airway segments isolated from Sprague Dawley rat in an organ bath set-up. It is demonstrated that the HMW and MMW fractions exhibited higher efficacy in relaxing the pre-contracted airways when compared to the CWE and LMW fraction. In addition, the HMW fraction markedly supressed carbachol-, 5-hydroxytrptamine-, and calcium-induced airway contractions. CWE demonstrated a lower efficacy than the HMW fraction but it also significantly attenuated carbachol- and calcium-induced airway contractions. Results showed that the bronchorelaxation effect of CWE and fractions is mediated via blockade of extracellular Ca2+ influx. The composition analysis revealed the following parts of carbohydrate and proteins, respectively: HMW fraction: 71 and 4%; MMW fraction: 35 and 1%; and LMW fraction: 22 and 0.3%. Our results strongly suggest that the polysaccharide–protein complex or proteins found in the HMW and MMW fractions is likely to contribute to the bronchorelaxation effect of CWE.

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“…This region consisted of two non-anomeric (3.3-4.6 ppm) and anomeric (4.8-5.8 ppm) signals, which can not be distinguished well due to the overlapping of the peaks. The signal at around 5.2 ppm could be attributed to the anomeric protons linked to Araf and the peak at 5.05 ppm for the -Araf nonreducing terminal (Nosalova et al, 2013). Galactopyranose signal peaks were also observed at the chemical shifts around 4.2, 3.7 and 3.4 ppm, respectively (Izumi, 1977).…”

Section: Purification and Chemical Composition Of Sfagmentioning

confidence: 94%

Pickering stabilization of thymol through green emulsification using soluble fraction of almond gum – Whey protein isolate nano-complexes

et al. 2019

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In this study, the soluble fraction of almond gum (SFAG) as a sustainable biopolymer source and whey protein isolate (WPI) were used for self-assembly preparation of SFAG-WPI nano-complexes through electrostatic interaction. The SFAG was characterized using 1 H and 13 C NMR. The influence of total biopolymer concentration (0.2-0.4 %w/v) and ratios (1:3-3:1) as well as of the pH (2-6) on the formation of complexes was established by visual, light scattering, surface charge, and spectrometric observations. The outcomes proved the formation of negatively charged soluble complexes in the range of pH 4-5 and insoluble complexes at pH values 3 to 4. The soluble coacervate particles at pH 4.5 and total concentration of 0.4 %w/v were selected to induce Pickering stabilization of thymol. The static light scattering with microscopy studies (CLSM and Cryo-SEM) showed the formation of thymol oil-in-water emulsions by adsorption of nano-complexes on the surface of the droplets. Thymol emulsions stabilized using complexes had no size variation under storage (40 days) with an opaque and homogenous appearance. On the other hand, the emulsions containing solely WPI at pH 4.5 showed a substantial droplet size increase with severe creaming. Droplet size analysis together with coalescence and flocculation indices presented that coalescence was mainly responsible for droplet size coarsening of the emulsions stabilized by native WPI at pH 4.5. Overall, our outcomes indicated the improvement of WPI in the stabilization of emulsions through complexation.

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Antitussive Activity of the Water-Extracted Carbohydrate Polymer fromTerminalia chebulaon Citric Acid-Induced Cough

Cited by 19 publications

References 37 publications

Prebiotic Potential of Herbal Medicines Used in Digestive Health and Disease

Prebiotic Potential of Herbal Medicines Used in Digestive Health and Disease

Airway Relaxation Effects of Water-Soluble Sclerotial Extract From Lignosus rhinocerotis

Pickering stabilization of thymol through green emulsification using soluble fraction of almond gum – Whey protein isolate nano-complexes

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