Antitumour-promoting and antitumour activities of the crude extract from the leaves of Juniperus chinensis

Ali, Abid; Mackeen, Muhammad Mukram Mohamed; Intan-Safinar, I.; Hamid, Muhajir; Lajis, Nordin Hj; El-Sharkawy, Saleh; Murakoshi, Michiaki

doi:10.1016/0378-8741(96)01434-1

Cited by 52 publications

(31 citation statements)

References 12 publications

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“…The extraction method was obtained from Ali, et al 7 with slight modification. The dried leaves (5 kg) of S.crispus was homogenized and soaked in chloroform 100% for a week.…”

Section: Preparation Of Extractmentioning

confidence: 99%

Cytotoxic effect of γ-sitosterol from Kejibeling (Strobilanthes crispus) and its mechanism of action towards c-myc gene expression and apoptotic pathway

et al. 2015

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Abstrak Metode: Penelitian in vitro ini menggunakan kultur sel kanker kolon manusia (Caco-2), sel kanker hepar manusia (HepG2), sel kanker payudara tergantung hormon (MCF-7) dan kultur sel normal hepar manusia (Chang Liver). Efek sitotoksik diukur melalui uji MTT melalui penentuan Abstract Background:This study aimed to analyze the cytotoxicity effect of γ-sitosterol isolated from "Kejibeling" (Strobilanthes crispus), a medicinal plant, on several cancer cell lines. The mechanisms of the effects were studied through the expression of cancer-caused gene, c-myc and apoptotic pathways.

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“…The extraction method was obtained from Ali, et al 7 with slight modification. The dried leaves (5 kg) of S.crispus was homogenized and soaked in chloroform 100% for a week.…”

Section: Preparation Of Extractmentioning

confidence: 99%

Cytotoxic effect of γ-sitosterol from Kejibeling (Strobilanthes crispus) and its mechanism of action towards c-myc gene expression and apoptotic pathway

et al. 2015

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“…14,15) The leaves of J. chinensis contains podophyllotoxin, a lignan with strong anti-leukemic and antitumor activities, 16,17) and sesquiterpene, a terpene with antifungal activity.…”

mentioning

confidence: 99%

Anti-obesity Effects of Juniperus chinensis Extract Are Associated with Increased AMP-Activated Protein Kinase Expression and Phosphorylation in the Visceral Adipose Tissue of Rats

Kim

Jung

Kim

et al. 2008

Biological & Pharmaceutical Bulletin

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“…The cells were cultured and maintained in growth medium as described by Ali et al [9]. Cytotoxic test were determined by performing the microtitration assay [10].…”

Section: Cytotoxic Assaymentioning

confidence: 99%

Cytotoxic and Anti-Tumour Promoting Activities of Carbazole Alkaloids from Malayan Murraya koenigii (L.) Spreng

Ahmad¹,

Tan²,

Sukari³

et al. 2014

AJPS

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Murraya koenigii (L.) (Rutaceae) is an indigenous medicinally important herb of Indian origin and now is widely distributed throughout southern Asia. The stem bark, leaves and roots of Malayan Murraya koenigii were selected for phytochemical investigation. Eight carbazole alkaloids was isolated and identified using spectroscopic methods including NMR, IR, UV, MS spectra data. Crude extract and isolated compounds from the roots of this plant were screened for cytotoxic activity and antitumor promoting activity. All crude extracts of the roots including the isolated compounds, mahanimbine, mahanine and murrayafoline-A exhibited significant cytotoxic activity against CEM-SS cell line with IC50 3 µg/mL. Girinimbine inhibited EBV-activation in the antitumor promoting assay.

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Antitumour-promoting and antitumour activities of the crude extract from the leaves of Juniperus chinensis

Cited by 52 publications

References 12 publications

Cytotoxic effect of γ-sitosterol from Kejibeling (<em>Strobilanthes crispus</em>) and its mechanism of action towards <em>c-myc</em> gene expression and apoptotic pathway

Cytotoxic effect of γ-sitosterol from Kejibeling (<em>Strobilanthes crispus</em>) and its mechanism of action towards <em>c-myc</em> gene expression and apoptotic pathway

Anti-obesity Effects of Juniperus chinensis Extract Are Associated with Increased AMP-Activated Protein Kinase Expression and Phosphorylation in the Visceral Adipose Tissue of Rats

Cytotoxic and Anti-Tumour Promoting Activities of Carbazole Alkaloids from Malayan <i>Murraya koenigii</i> (L.) Spreng

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Antitumour-promoting and antitumour activities of the crude extract from the leaves of Juniperus chinensis

Cited by 52 publications

References 12 publications

Cytotoxic effect of γ-sitosterol from Kejibeling (<em>Strobilanthes crispus</em>) and its mechanism of action towards <em>c-myc</em> gene expression and apoptotic pathway

Cytotoxic effect of γ-sitosterol from Kejibeling (<em>Strobilanthes crispus</em>) and its mechanism of action towards <em>c-myc</em> gene expression and apoptotic pathway

Anti-obesity Effects of Juniperus chinensis Extract Are Associated with Increased AMP-Activated Protein Kinase Expression and Phosphorylation in the Visceral Adipose Tissue of Rats

Cytotoxic and Anti-Tumour Promoting Activities of Carbazole Alkaloids from Malayan &lt;i&gt;Murraya koenigii&lt;/i&gt; (L.) Spreng

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Cytotoxic and Anti-Tumour Promoting Activities of Carbazole Alkaloids from Malayan <i>Murraya koenigii</i> (L.) Spreng