Antitumour potential of pollen extract on lewis lung carcinoma implanted intraperitoneally in syngeneic mice

Furusawa, Eiichi; Chou, S.C.; Hirazumi, Anne; Melera, A.

doi:10.1002/ptr.2650090405

Cited by 26 publications

(21 citation statements)

References 15 publications

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“…A variety of primary and secondary metabolites contained in bee pollen exhibit a wide range of properties and bioactivities, i.e. antioxidant, anti‐inflammatory, anticarcinogenic, antibacterial, antifungicidal, hepatoprotective, and anti‐atherosclerotic activities capable of modifying or regulating immune functions (Fig. ) .…”

Section: Bee Pollenmentioning

confidence: 99%

Biological and therapeutic properties of bee pollen: a review

2016

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Natural products, including bee products, are particularly appreciated by consumers and are used for therapeutic purposes as alternative drugs. However, it is not known whether treatments with bee products are safe and how to minimise the health risks of such products. Among others, bee pollen is a natural honeybee product promoted as a valuable source of nourishing substances and energy. The health-enhancing value of bee pollen is expected due to the wide range of secondary plant metabolites (tocopherol, niacin, thiamine, biotin and folic acid, polyphenols, carotenoid pigments, phytosterols), besides enzymes and co-enzymes, contained in bee pollen. The promising reports on the antioxidant, anti-inflammatory, anticariogenic antibacterial, antifungicidal, hepatoprotective, anti-atherosclerotic, immune enhancing potential require long-term and large cohort clinical studies. The main difficulty in the application of bee pollen in modern phytomedicine is related to the wide species-specific variation in its composition. Therefore, the variations may differently contribute to bee-pollen properties and biological activity and thus in therapeutic effects. In principle, we can unequivocally recommend bee pollen as a valuable dietary supplement. Although the bee-pollen components have potential bioactive and therapeutic properties, extensive research is required before bee pollen can be used in therapy. © 2016 Society of Chemical Industry.

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Section: Bee Pollenmentioning

confidence: 99%

Biological and therapeutic properties of bee pollen: a review

2016

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“…When analyzing and studying the nutritional and therapeutic properties of bee pollen, modern science has made it possible to specify its valuable antimicrobial [2], antifungal [3], antioxidant [4], anti-radiation [5], hepatoprotective [6], chemopreventive [7], anticancer [8] and antiinflammatory activities [9].…”

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confidence: 99%

Chemical composition and antioxidant activity of <i>Apis mellifera</i> bee pollen from northwest Algeria

Rebiai¹,

Lanez²

2015

J. Fundam and Appl Sci.

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The aim of this study was to assess the nutritional composition and antioxidant activity of bee pollen produced in the North western region of Algeria. The content of total phenolic compounds, flavonoids, and antioxidant activity using the molybdate ion reduction method were determined. The mean contents of phenolic compounds and total flavonoids were 30.46 ± 8.22 mg of GAE.g -1 pollen and 8.92 ± 5.5 mg of RE.g -1 pollen, respectively. High antioxidant activities were found for the molybdate ion reduction method, with values that ranged from 71.95 to 101.5 μg of GAE.g -1 pollen. The bee pollen of Boufarik showed high antioxidant activity probably due to the high content of phenolic compounds present in pollen.

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“…Filipendula ulmaria pollen antitumour activity on the floral source origin (Furusawa et al, 1995;Komosinska-Vassev et al, 2015). Another important bioactive group of pollen compounds are the phytosterols.…”

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confidence: 99%

Antiproliferative activity and apoptotic effects of Filipendula ulmaria pollen against C26 mice colon tumour cells

Mărgăoan

Zăhan

Mărghitaș

et al. 2016

Journal of Apicultural Science

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A b s t r a c t Honeybee collected pollen exhibits high nutritional and pharmaceutical benefits for the human diet and medicine. Pollen's antioxidant, anti-ageing, anti-inflammatory, anti-atherosclerosis, and cardioprotective activity, depending on the floral origin, are well known. Recent studies proposed that pollen may also be an excellent cancer-fighting candidate, as pollen harbours high amounts of phenolic substances. In our study, Filipendula ulmaria pollen (bee collected) was methanol-water extracted and used to verify its in vitro pharmacological activities on C26 mice cancer tumour cells. Three different concentrations of the extract were tested in antitumour assays. Monitoring was done after 6, 12, 24, and 48 hours. Promising results were obtained for antiproliferative and apoptotic activity of the pollen extracts, with high efficiency for the highest concentration (1 mg/mL). For both activities, time and concentration-dependent effects were observed. Pollen extracts or bee collected pollen has a high potential as an antitumour agent for use in human medicine, because they are both rich in bioactive compounds.

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Antitumour potential of pollen extract on lewis lung carcinoma implanted intraperitoneally in syngeneic mice

Cited by 26 publications

References 15 publications

Biological and therapeutic properties of bee pollen: a review

Biological and therapeutic properties of bee pollen: a review

Chemical composition and antioxidant activity of <i>Apis mellifera</i> bee pollen from northwest Algeria

Antiproliferative activity and apoptotic effects of Filipendula ulmaria pollen against C26 mice colon tumour cells

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