Antitumour potential of pleural cavity macrophages in lung cancer patients without malignant effusion

Kimura, Satoshi; Sone, Saburo; Takahashi, K.; Uyama, Tadashi; Ogura, Takeshi; Monden, Yasumasa

doi:10.1038/bjc.1989.109

Cited by 9 publications

(5 citation statements)

References 27 publications

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“…Data on the pleural lavage cytology are mainly derived from pathological effusion in tumor patients [14,15]. Limited information is available about the cellular composition of the pleural cavity in healthy humans.…”

Section: Discussionmentioning

confidence: 99%

Pleural macrophages are the dominant cell population in the thoracic cavity with an inflammatory cytokine profile similar to peritoneal macrophages

et al. 2007

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Numerous human macrophage (mphi) subpopulations with different behavior have been identified in adults. It is well known that peritoneal mphi are activated by abdominal surgery and subsequently contribute to a systemic inflammatory response that leads to immune suppression, increased morbidity and mortality. Information on the role of pleural mphi in adults is scarce and information on their role in children is lacking. We investigated the behavior of pleural versus peritoneal mphi in children and adolescents. As a first step, we compared the cellular composition of the pleural and peritoneal surface in children and adolescents. Pleural and peritoneal lavages were performed in 21 patients undergoing non-contaminated laparoscopic and thoracoscopic surgical procedures. We observed a significantly higher percentage of mphi in the pleural compared to the peritoneal cavity with less lymphocytes, a small amount of polymorphonuclear cells (PMNs) and other cells. To further study the mphi inflammatory response, we measured the spontaneous and LPS triggered cytokine release of isolated pleural versus peritoneal mphi (IL-1beta, IL-6, and IL-10). The pattern of cytokine release was similar in both, pleural and peritoneal mphi. Directly after lavage, they showed a strong activation, with no difference between stimulated and non-stimulated cells. After 24 h resting, mphi of both compartments reacted to LPS with a similar significant increase in the cytokine release. In conclusion, our results demonstrate that pleural mphi represent the dominant cell population in the pleural cavity of the young. They show a similar inflammatory response as peritoneal mphi and should be considered to play a major role in the local inflammatory response to thoracic surgery.

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Section: Discussionmentioning

confidence: 99%

Pleural macrophages are the dominant cell population in the thoracic cavity with an inflammatory cytokine profile similar to peritoneal macrophages

et al. 2007

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“…Since human A375 melanoma cells were found to be susceptible to cytotoxicity by IL-1 and tumor necrosis factor (TNF) [18], one possibility is that the production of monokines (IL-1 and TNF) responsible for tumor cell killing may be regulated by different mechanisms, depending on the activation stimulus, the functional state or maturation of monocytes or the influence of cancer bearing. In fact, the productions of IL-1 and T N F are known to be regulated by differential mechanism [1,11].…”

Section: Discussionmentioning

confidence: 99%

Tumor cytotoxicity and interleukin 1 production of blood monocytes of lung cancer patients

Sone

Utsugi

Tandon

et al. 1990

Cancer Immunol Immunother

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The effects of lung cancer on the abilities of blood monocytes to produce interleukin-1 and to mediate antitumor activity were examined. The functional integrity of blood monocytes was determined by their capacity to respond in vitro to a variety of activating agents and become tumoricidal, as assessed by a radioactive release assay and ability to produce interleukin-1 in vitro. The results show that the presence of lung cancer significantly increased the number of harvested blood monocytes and that the spontaneous tumoricidal activity of these monocytes was slightly high as compared to monocytes obtained from healthy donors. The production of interleukin-1 by monocytes of healthy donors and lung cancer patients was similar. Blood monocytes obtained from lung cancer patients were less cytotoxic against allogeneic A375 melanoma cells as compared with those of healthy donors subsequent to incubation with a soluble muramyl dipeptide analog or lipopolysaccharide, but were as tumoricidal as those from healthy donors when activated with lipophilic muramyl tripeptide (MTP-PE) entrapped in multilamellar liposomes. The finding that monocytes of patients with lung cancer can respond to MTP-PE encapsulated in liposomes, recommends the use of these liposomes in therapy of human lung cancer.

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“…Itoh et al [11], for example, have reported cytolytic activity against fresh melanoma targets by unstimulated PBM, and Kimura et al [13] have shown that human PBM and alveolar macrophages can mediate cytotoxicity without deliberate activation. However, the enhancement of tumour cell growth by human PBM has not been reported extensively.…”

Section: Discussionmentioning

confidence: 97%

Differential effects of human blood monocytes on the growth of human tumour cell lines in vitro

Parry

Rees

1992

Cancer Immunol Immunother

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Monocytes and macrophages have been shown to be cytotoxic towards tumour cells in vitro. However, although tumour-associated monocytes and macrophages are now widely accepted to contribute a relatively high proportion of the cellular infiltrate of experimental and human solid carcinomas, a cytotoxic/cytostatic effector function for these cells in vitro or in vivo has yet to be conclusively demonstrated. In the present study, we show that non-activated peripheral blood monocytes co-cultured with tumour cells across a semi-permeable membrane release soluble factors that modulate the growth of tumour cells in contrasting ways. After Nycoprep 1.068 separation, non-activated peripheral blood monocytes enhanced the in vitro proliferation of HT29 colon adenocarcinoma cells but inhibited T47D breast carcinoma cell replication; peripheral blood lymphocytes were incapable of mediating these effects. In contrast, peripheral blood monocytes activated by interferon gamma caused a pronounced inhibition of both HT29 and T47D cell proliferation.

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Antitumour potential of pleural cavity macrophages in lung cancer patients without malignant effusion

Cited by 9 publications

References 27 publications

Pleural macrophages are the dominant cell population in the thoracic cavity with an inflammatory cytokine profile similar to peritoneal macrophages

Pleural macrophages are the dominant cell population in the thoracic cavity with an inflammatory cytokine profile similar to peritoneal macrophages

Tumor cytotoxicity and interleukin 1 production of blood monocytes of lung cancer patients

Differential effects of human blood monocytes on the growth of human tumour cell lines in vitro

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