Antitumour and anti-haematotoxic activity of Asparagus racemosus L total dissolved solids in co-administration with cyclophosphamide in mice

Benil, P.B.; Nimisha, P.; Arokiyaraj, Selvaraj; Rajakrishnan, R.; Alfarhan, Ahmed; Al-Ansari, Abdullah

doi:10.1016/j.jksus.2020.04.016

Cited by 9 publications

(3 citation statements)

References 18 publications

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“…A couple of studies depicted the antitumor activities of AR with or without clinically utilised chemotherapeutic drugs ( Mitra et al, 2012 ; Benil et al, 2020 ). Similarly, our team has previously mapped several pharmacological activities of WS reported in various cancer models indicating its ability to influence the classical hallmarks of cancer ( Saggam et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Ayurveda-based Botanicals as Therapeutic Adjuvants in Paclitaxel-induced Myelosuppression

et al. 2022

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Chemotherapy-induced myelosuppression is one of the major challenges in cancer treatment. Ayurveda-based immunomodulatory botanicals Asparagus racemosus Willd (AR/Shatavari) and Withania somnifera (L.). Dunal (WS/Ashwagandha) have potential role to manage myelosuppression. We have developed a method to study the effects of AR and WS as therapeutic adjuvants to counter paclitaxel (PTX)-induced myelosuppression. Sixty female BALB/c mice were divided into six groups—vehicle control (VC), PTX alone, PTX with aqueous and hydroalcoholic extracts of AR (ARA, ARH) and WS (WSA, WSH). The myelosuppression was induced in mice by intraperitoneal administration of PTX at 25 mg/kg dose for three consecutive days. The extracts were orally administered with a dose of 100 mg/kg for 15 days prior to the induction with PTX administration. The mice were observed daily for morbidity parameters and were bled from retro-orbital plexus after 2 days of PTX dosing. The morbidity parameters simulate clinical adverse effects of PTX that include activity (extreme tiredness due to fatigue), behavior (numbness and weakness due to peripheral neuropathy), body posture (pain in muscles and joints), fur aspect and huddling (hair loss). The collected samples were used for blood cell count analysis and cytokine profiling using Bio-Plex assay. The PTX alone group showed a reduction in total leukocyte and neutrophil counts (4,800 ± 606; 893 ± 82) when compared with a VC group (9,183 ± 1,043; 1,612 ± 100) respectively. Pre-administration of ARA, ARH, WSA, and WSH extracts normalized leukocyte counts (10,000 ± 707; 9,166 ± 1,076; 10,333 ± 1,189; 9,066 ± 697) and neutrophil counts (1,482 ± 61; 1,251 ± 71; 1,467 ± 121; 1,219 ± 134) respectively. Additionally, higher morbidity score in PTX group (7.4 ± 0.7) was significantly restricted by ARA (4.8 ± 1.1), ARH (5.1 ± 0.6), WSA (4.5 ± 0.7), and WSH (5 ± 0.8). (Data represented in mean ± SD). The extracts also significantly modulated 20 cytokines to evade PTX-induced leukopenia, neutropenia, and morbidity. The AR and WS extracts significantly prevented PTX-induced myelosuppression (p < 0.0001) and morbidity signs (p < 0.05) by modulating associated cytokines. The results indicate AR and WS as therapeutic adjuvants in cancer management.

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Section: Discussionmentioning

confidence: 99%

Ayurveda-based Botanicals as Therapeutic Adjuvants in Paclitaxel-induced Myelosuppression

et al. 2022

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“…As the diagnosis of cancer is possible but the survival rate is low till today. Asparagus racemosus is a widely distributed medicinal plant having anti-tumour activity (Benal P B. et al, 2020) [17] .…”

Section: Anti-tumour Activitymentioning

confidence: 99%

Asparagus racemosus: Many problems, one solution on its phytochemical and pharmacological potential

Bishoyi¹,

Tripathy²

2023

J. Med. Plants Stud.

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Asparagus racemosus is commonly called as satamuli, satavari, satawar found in low altitudes throughout India and belongs to family Liliaceae. It is an important ethnomedicinal plant of tropical and subtropical India. Asparagus racemosus has seen widely described to benefit an immune stimulant, antioxidant, anti-abortifacient (shatvarin-1), anti-dyspepsia, anti-tussive effects. It is also beneficial for treatment of liver cancer, stomach ulcers, excessive heat chronic fevers, kidney disorders, epilepsy, increases milk secretion in nursing mothers and regulates sexual behaviours. The major active phytoconstitutents to of Asparagus racemosus are asparagamine, racemosol, isoflavones, steroidal saponins, mucilage, Vitamins -A, B₁, B₂, C, E, Mg, P, Ca, Fe, and folic acid present in roots. Asparagus racemosus has been specially suggested of threatened abortion, galactagogue as well as restorative action as it is beneficial in women's complaints. This review summarizes the phytochemical pharmacogenetic and pharmacological aspects of Asparagus racemosus.

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“…Plant derived phytochemicals were the primary resources exploited for human needs [ 3 ]. Several plant-derived phytochemicals were investigated for their activity against chronic debilitating diseases and have found to act through multiple pathways including their disease modifying effect and by general mechanisms like antioxidant defense [ 4 , 5 ]. But, in the present scenario, where the disease-causing agents have attained resistance against the drug, these medicines failed drastically.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activities of two potential peptides extracted from Polistes wattii Cameron, 1900 (Vespidae: Polistinae) wasp venom collected at Eastern Province, Saudi Arabia

Al-Shammery

Hozzein

2022

PLoS ONE

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Alternatives of conventional antibiotics have become an urgent need to control drug-resistant bacteria. Therefore, search for new antibacterial agents has become a trend in several microbiological and pharmaceutical scientific works. Insects, one of the most successful and evolved species on earth is known to be an effective natural source of several medically useful chemicals including antibacterial agents. There is considerable evidence of using wasp venom against medical ailments in several parts of the world. In this work venom from Polistes wattii Cameron, 1900 collected from Eastern Province, Saudi Arabia was evaluated for its antibacterial activities. Such activity was tested against four pathogenic bacteria: two-gram positive Staphylococcus aureus (ATCC 25923) and Streptococcus mutans (RCMB 017(1) ATCC 25175) and two gram-negative (Salmonella typhimurium NCTC 12023 ATCC 14028 and Enterobacter cloacae (RCMB 001(1) ATCC 23355). Also, chemical characterization of wasp venom was done using HPLC and two isolated peptides were sequenced. The result indicates the potent anti-microbial effect of the venom against the four tested bacteria. The most sensitive bacteria were Staphylococcus aureus (ATCC 25923) and Streptococcus mutans (RCMB 017(1) ATCC 25175). The sequence of the two purified peptides indicates that they belong to mastoparan. The study results may pave way to use this wasp venom in future antibiotics especially in controlling skin infection by Staphylococcus aureus.

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Antitumour and anti-haematotoxic activity of Asparagus racemosus L total dissolved solids in co-administration with cyclophosphamide in mice

Cited by 9 publications

References 18 publications

Ayurveda-based Botanicals as Therapeutic Adjuvants in Paclitaxel-induced Myelosuppression

Ayurveda-based Botanicals as Therapeutic Adjuvants in Paclitaxel-induced Myelosuppression

Asparagus racemosus: Many problems, one solution on its phytochemical and pharmacological potential

Antibacterial activities of two potential peptides extracted from Polistes wattii Cameron, 1900 (Vespidae: Polistinae) wasp venom collected at Eastern Province, Saudi Arabia

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