Antitumour activity of tin compounds

Crowe, Alan J.

doi:10.1007/978-94-011-1252-9_7

Cited by 36 publications

(20 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Data were collected with q values between 2 and 258 (1) or 1.8 and 258 (5). Range of hkl: h = À11 to 11, k = À24 to 24, l = 0 to 11 (1); h = À9 to 9, k = À13 to 14, l = 0 to 15 (5). The intensities of 6962 (1) and 4024 (5) reflections were observed and a total of 3335 (1) and 3837 (5) (R int = 0.029 and 0.014, respectively) unique reflections were used for structure solution and refinement.…”

Section: Methodsmentioning

confidence: 99%

Diorganotin(IV) Derivatives of Substituted Benzohydroxamic Acids with High Antitumor Activity

Liu

Silva

Pombeiro³

2004

Chemistry A European J

107

View full text Add to dashboard Cite

A series of diorganotin(IV) and dichlorotin(IV) derivatives of 4-X-benzohydroxamic acids, [HL(1) (X = Cl) or HL(2) (X = OCH(3))] formulated as [R(2)SnL(2)] (R = Me, Et, nBu, Ph or Cl; L = L(1) or L(2)), along with their corresponding mixed-ligand complexes [R(2)Sn(L(1))(L(2))] have been prepared and characterized by FT-IR, (1)H, (13)C, and (119)Sn NMR spectroscopy, mass spectrometry, elemental analysis, and melting points. In addition, single-crystal X-ray diffraction analyses were carried out for [Me(2)SnL(2)] (L = L(1) or L(2)), which show coordination structures intermediate between distorted octahedra and bicapped tetrahedra. The hydroxamate ligands are asymmetrically coordinated by the oxygen atoms, the carbonyl oxygen atom is further away from the metal center than the other oxygen atom. The complexes are stable monomeric species; most of them are soluble not only in chlorohydrocarbon solvents, but also in alcohols and hydroalcoholic solutions. In polar solvents, the mixed-ligand complexes gradually decompose into the corresponding single-ligand complex couples. The complexes exhibit in vitro antitumor activities (against a series of human tumor cell lines) which, in some cases, are identical to, or even higher than, that of cisplatin. For the dialkyltin complexes, the activity increases with the length of the carbon chain of the alkyl ligand and is higher in the case of the chloro-substituted benzohydroxamato ligand. The [nBu(2)Sn(L(1))(2)] complex displays a high in vivo activity against H22 liver and BGC-823 gastric tumors, and has a relatively low toxicity.

show abstract

Section: Methodsmentioning

confidence: 99%

Diorganotin(IV) Derivatives of Substituted Benzohydroxamic Acids with High Antitumor Activity

Liu

Silva

Pombeiro³

2004

Chemistry A European J

107

View full text Add to dashboard Cite

show abstract

“…21 The X-ray crystal structure of 3 has been determined. The solution-and solid-state structures of these compounds have been further addressed by 1 H, 13 C and 117 Sn NMR spectroscopy, as well as by 119m Sn Mössbauer, IR spectroscopy and mass spectrometry. Their in vitro antitumour activity is reported.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5] However, diorganotin(IV) derivatives of bis(carboxymethyl)amines and some N-substituted analogues have been investigated only to a limited extent. 6,7 This is probably due to the fact that only some ligands are commercially available and methods for their preparation are not numerous.…”

Section: Introductionmentioning

confidence: 99%

Di‐n‐butyltin(IV) derivatives of bis(carboxymethyl)benzylamines: synthesis, NMR and X‐ray structure characterization and in vitro antitumour properties

Mancilla

Carrillo

Zamudio‐Rivera

et al. 2001

Applied Organom Chemis

View full text Add to dashboard Cite

Four di-n-butyltin(IV) derivatives of bis(carboxymethyl)benzylamines were synthesized and their structure characterized by 1 H, 13C and 117/119 Sn NMR, Mössbauer spectroscopy and mass spectrometry. The derivative substituted in the meta position by a methyl group has been further characterized by X-ray crystallography. This compound exhibits a distorted trigonal bipyramidal geometry at tin. The NMR data in solution, as well as other spectroscopic results in the solid state, confirm this structure for all the compounds. Evidence is provided to show that the compounds are more highly associated in concentrated solution than in the solid state. Their in vitro antitumour activity is reported.

show abstract

“…Moreover, one of the fields that has been more studied and reviewed is the activity of such compounds against cancer [6][7][8][9][10][11][12]. Those with biologically active ligands have attracted a particular attention toward the design of potential antitumor agents.…”

Section: Introductionmentioning

confidence: 99%

Polynuclear diorganotin(IV) complexes with arylhydroxamates: Syntheses, structures and in vitro cytotoxic activities

Shang

Cui

et al. 2008

Journal of Inorganic Biochemistry

View full text Add to dashboard Cite

Antitumour activity of tin compounds

Cited by 36 publications

References 66 publications

Diorganotin(IV) Derivatives of Substituted Benzohydroxamic Acids with High Antitumor Activity

Diorganotin(IV) Derivatives of Substituted Benzohydroxamic Acids with High Antitumor Activity

Di‐n‐butyltin(IV) derivatives of bis(carboxymethyl)benzylamines: synthesis, NMR and X‐ray structure characterization and in vitro antitumour properties

Polynuclear diorganotin(IV) complexes with arylhydroxamates: Syntheses, structures and in vitro cytotoxic activities

Contact Info

Product

Resources

About