Antitumour activity of platinum analogues against human yolk sac tumours heterotransplanted in nude mice

Sawada, Masumi; Matsui, Yoshitaka; Okudaira, Y

doi:10.1038/bjc.1986.68

Br J Cancer

1986

DOI: 10.1038/bjc.1986.68

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Antitumour activity of platinum analogues against human yolk sac tumours heterotransplanted in nude mice

Masumi Sawada¹,

Yoshitaka Matsui²,

Y Okudaira³

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Cited by 5 publications

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“…We therefore looked for an in vivo experimental system in order to examine hormone responsiveness of ovarian cancer. Since 1977, we have been using a human tumor transplantation system using nude mice to help determine the nature of the tumor and to screen anti-tumor drugs (Sawada et a[., 1981(Sawada et a[., , 1982(Sawada et a[., , 1983(Sawada et a[., , 1985(Sawada et a[., , 1986(Sawada et a[., , 1987. This present paper describes sex steroid-responsive growth of a newly-established line of ovarian tumors heterotransplanted into nude mice and designated OVA-5.…”

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confidence: 99%

Estrogen‐ and androgen‐responsive growth of human ovarian adenocarcinoma heterotransplanted into nude mice

Sawada

Terada

Wada

et al. 1990

Intl Journal of Cancer

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A new line of human serous cystadenocarcinoma of the ovary, designated OVA-5, has been established in athymic nude mice. A strong correlation was noted between tumor volume and plasma CA125 levels in mice bearing OVA-5 tumor. Growth of the OVA-5 tumor in castrated male nude mice was accelerated by s.c. administration of estradiol-17 beta and 5 alpha-dihydrotestosterone but not by progesterone. Estradiol-17 beta and 5 alpha-dihydrotestosterone also accelerated the growth of the OVA-5 tumor heterotransplanted into sialoadenectomized castrated male nude mice. No remarkable change was observed in the histological appearances of the tumors between control groups and hormone-treated groups. Receptor assays revealed that the OVA-5 tumor had both estrogen and androgen receptors. Growth of the OVA-5-tumor is thus responsive to estrogen and androgen.

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Estrogen‐ and androgen‐responsive growth of human ovarian adenocarcinoma heterotransplanted into nude mice

Sawada

Terada

Wada

et al. 1990

Intl Journal of Cancer

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Establishment of human ovarian tumour lines in nude mice and their responses to platinum analogues

Sawada¹,

Ozaki²,

Mori³

et al. 1987

European Journal of Cancer and Clinical Oncology

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Evaluation of mouse lip mucosa reactions after combinations of cis-diammine-1,1-cyclobutanedicarboxylate platinum (II) (CBDCA) and irradiation: Single and fractionated treatments

Landuyt

Keizer

Chin

et al. 1987

International Journal of Radiation Oncology*Biology*Physics

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Antitumour activity of platinum analogues against human yolk sac tumours heterotransplanted in nude mice

Cited by 5 publications

References 10 publications

Estrogen‐ and androgen‐responsive growth of human ovarian adenocarcinoma heterotransplanted into nude mice

Estrogen‐ and androgen‐responsive growth of human ovarian adenocarcinoma heterotransplanted into nude mice

Establishment of human ovarian tumour lines in nude mice and their responses to platinum analogues

Evaluation of mouse lip mucosa reactions after combinations of cis-diammine-1,1-cyclobutanedicarboxylate platinum (II) (CBDCA) and irradiation: Single and fractionated treatments

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