Antitumour activity of 3-chlorodeoxylapachol, a naphthoquinone from <i>Avicennia germinans</i> collected from an experimental plot in southern Florida

Jones, W.P.; Lobo-Echeverri, Tatiana; Mi, Qiuwen; Chai, Heebyung; Lee, Dong‐Ho; Soejarto, Djaja D.; Cordell, Geoffrey A.; Pezzuto, John M.; Swanson, Steven M.; Kinghorn, A. Douglas

doi:10.1211/jpp.57.9.0005

Cited by 30 publications

(6 citation statements)

References 29 publications

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“…in mice bearing fibers filled with KB (oral cancer), LNCaP (prostate cancer), and hTERT-RPE1 (pigment epithelial) cells inserted into the peritoneal cavity and under the skin. 3-Chlorodeoxylapachol at the dose of 5 mg/Kg displayed significant in vivo reduction of the engineered KB tumors [59]. Furthermore, Prabhu et al reported an antitumoral activity for Rhyzophora apiculata extracts in the melanoma mice model B16F10 when mice were treated daily with 10 mg/Kg of mangrove extracts during ten days.…”

Section: Mangroves and Other Higher Plantsmentioning

confidence: 99%

From Seabed to Bedside: A Review on Promising Marine Anticancer Compounds

et al. 2020

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The marine environment represents an outstanding source of antitumoral compounds and, at the same time, remains highly unexplored. Organisms living in the sea synthesize a wide variety of chemicals used as defense mechanisms. Interestingly, a large number of these compounds exert excellent antitumoral properties and have been developed as promising anticancer drugs that have later been approved or are currently under validation in clinical trials. However, due to the high need for these compounds, new methodologies ensuring its sustainable supply are required. Also, optimization of marine bioactives is an important step for their success in the clinical setting. Such optimization involves chemical modifications to improve their half-life in circulation, potency and tumor selectivity. In this review, we outline the most promising marine bioactives that have been investigated in cancer models and/or tested in patients as anticancer agents. Moreover, we describe the current state of development of anticancer marine compounds and discuss their therapeutic limitations as well as different strategies used to overcome these limitations. The search for new marine antitumoral agents together with novel identification and chemical engineering approaches open the door for novel, more specific and efficient therapeutic agents for cancer treatment.

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Section: Mangroves and Other Higher Plantsmentioning

confidence: 99%

From Seabed to Bedside: A Review on Promising Marine Anticancer Compounds

et al. 2020

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“…Numerous other mangrove species have been reported with anticancer potential. Antitumor activity of 3-chlorodeoxylapachol, a naphthoquinone obtain beginning Avicennia germinans has been demonstrated 25 .…”

Section: Anticancer Activitymentioning

confidence: 99%

Therapeutic and Traditional Uses of Mangrove Plants

Vinoth¹,

Kumaravel²,

Ranganathan³

2019

J. Drug Delivery Ther.

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Mangrove plants are specialized timbered plants growing in the swamps of tidal coastal areas and stream deltas of tropical and subtropical parts of the world. They have been utilized for medicinal and traditional purposes by the coastal folks over the years. A large number of mangrove plants grows natural and exploited especially, for use in indigenous pharmaceutical houses. Several mangroves genus produce expensive drugs which have high export potential. The utilization of plants and plant products as medicines could be traced as far back as the commencement of human civilization. Mangrove plants have been used in folklore medicines and extracts from mangrove species have prove inhibitory activity against human, animal and plant pathogens. Traditionally, the mangroves have been exploited for firewood and charcoal. Exploit has been found for mangroves in the manufacture of dwellings, furniture, boats and fishing gear, tannins for dyeing and leather production. The mangroves afford food and wide variety of traditional products and artefacts for the mangrove dwellers. The present review deals with the pharmacological activity, medicinal, traditional and produce bioactive compounds of mangrove medicinal plants. Keywords: Mangroves, Medicinal, Pharmacological, Recourses, Traditional.

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“…Several other mangrove species have been reported with anticancer potential. Antitumor activity of 3-chlorodeoxylapachol, a naphthoquinone obtained from Avicennia germinans has been demonstrated [ 83 ]. Cytotoxicity of limonoids isolated from seeds of Xylocarpus granatum against P-388 and A-549 tumor cell lines has been reported [ 84 ].…”

Section: Pharmacological Activities Of Heritiera Fomes mentioning

confidence: 99%

Pharmacological and Ethnomedicinal Overview of Heritiera fomes: Future Prospects

Mahmud

Islam

Saha

et al. 2014

International Scholarly Research Notices

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Mangrove plants are specialized woody plants growing in the swamps of tidal-coastal areas and river deltas of tropical and subtropical parts of the world. They have been utilized for medicinal and other purposes by the coastal people over the years. Heritiera fomes Buch. Ham. (family: Sterculiaceae) commonly known as Sundari (Bengali) is a preeminent mangrove plant occurring in the Sundarbans forest located in the southern part of Bangladesh and adjoining West Bengal province of India. The plant has applications in traditional folk medicine as evidenced by its extensive use for treating diabetes, hepatic disorders, gastrointestinal disorders, goiter, and skin diseases by the local people and traditional health practitioners. A number of investigations indicated that the plant possesses significant antioxidant, antinociceptive, antihyperglycemic, antimicrobial, and anticancer activities. Phytochemical analyses have revealed the presence of important chemical constituents like saponins, alkaloids, glycosides, tannins, steroids, flavonoids, gums, phytosterols, and reducing sugars. The present study is aimed at compiling information on phytochemical, biological, pharmacological, and ethnobotanical properties of this important medicinal plant, with a view to critically assess the legitimacy of the use of this plant in the aforementioned disorders as well as providing directions for further research.

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Antitumour activity of 3-chlorodeoxylapachol, a naphthoquinone from Avicennia germinans collected from an experimental plot in southern Florida

Cited by 30 publications

References 29 publications

From Seabed to Bedside: A Review on Promising Marine Anticancer Compounds

From Seabed to Bedside: A Review on Promising Marine Anticancer Compounds

Therapeutic and Traditional Uses of Mangrove Plants

Pharmacological and Ethnomedicinal Overview of Heritiera fomes: Future Prospects

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