2006
DOI: 10.1074/jbc.m604145200
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Antitumorigenic Effect of Wnt 7a and Fzd 9 in Non-small Cell Lung Cancer Cells Is Mediated through ERK-5-dependent Activation of Peroxisome Proliferator-activated Receptor γ

Abstract: The Wnt pathway is critical for normal development, and mutation of specific components is seen in carcinomas of diverse origins. The role of this pathway in lung tumorigenesis has not been clearly established. Recent studies from our laboratory indicate that combined expression of the combination of Wnt 7a and Frizzled 9 (Fzd 9) in Non-small Cell Lung Cancer (NSCLC) cell lines inhibits transformed growth. We have also shown that increased expression of peroxisome proliferator-activated receptor ␥ (PPAR␥) inhi… Show more

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Cited by 108 publications
(137 citation statements)
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“…In nonsmall cell lung carcinoma, Wnt7a was reported to function as a tumor suppressor gene. The anti-tumorgenic effects of Wnt7a interacting with the specific receptor Fzd9 was mainly mediated through ERK-dependent activation of the nuclear receptor gene PPARγ [15]. On the other hand, Wnt7a positively regulated E-cadherin in lung carcinoma cell.…”
Section: Discussionmentioning
confidence: 88%
See 1 more Smart Citation
“…In nonsmall cell lung carcinoma, Wnt7a was reported to function as a tumor suppressor gene. The anti-tumorgenic effects of Wnt7a interacting with the specific receptor Fzd9 was mainly mediated through ERK-dependent activation of the nuclear receptor gene PPARγ [15]. On the other hand, Wnt7a positively regulated E-cadherin in lung carcinoma cell.…”
Section: Discussionmentioning
confidence: 88%
“…Wnt7a was overexpressed in the cell lines of colorectal carcinoma, pancreatic carcinoma, gastric carcinoma and breast carcinoma [14]. However, Wnt7a has been reported to function as a tumor suppressor gene in non-small cell lung carcinoma [15]. In addition, the Wnt7a gene was also found to be down-regulated because of hypermethylation at high frequency in pancreatic carcinoma [16].…”
mentioning
confidence: 99%
“…Together, these data strongly suggest that FZD9 is located in the postsynaptic region of hippocampal neurons. (32)(33)(34). To assess whether FZD9 might also mediates the Wnt-5a cascade, we first performed a ligandreceptor binding assay between recombinant Wnt-5a and the cysteine-rich domain (CRD) of FZD9, which is a Wnt-binding domain (35).…”
Section: Postsynaptic Distribution Of the Fzd9 Receptor In Hippocam-mentioning
confidence: 99%
“…Ghosh et al (2005) showed that exogenous expression of c-myc promoter-binding protein 1 induces prostate cancer cell death by downregulating the expression of MEK5a and upregulating the level of MEK5b. There are also some studies indicating that MEK5 plays an important role in the carcinogenesis of hepatocellular cancer (Yan et al, 2009) and lung cancer (Winn et al, 2006). However, few studies have investigated the role of MEK5 in sporadic CRC.…”
Section: Mek5 Polymorphisms and Cancermentioning
confidence: 99%
“…Further, it is thought that MEK5 is directly involved in the progress of malignancies and tumorigenesis (Song et al, 2004). There are many studies suggesting that MEK5 plays a critical role in cancer occurrence and progression, such as prostate cancer (Mehta et al, 2003;McCracken et al, 2008), breast cancer (Li et al, 2008), hepatocellular cancer (Yan et al, 2009), and lung cancer (Winn et al, 2006). However, the association between MEK5 and CRC remains unclear.…”
Section: Introductionmentioning
confidence: 99%