Antitumor quinazoline alkaloids from the seeds of<i>Peganum harmala</i>

Wang, Chunhua; Zeng, Hong; Wang, Yi-Hai; Li, Chuan; Cheng, Jun; Ye, Zhijun; He, Xiangjiu

doi:10.1080/10286020.2015.1042373

Cited by 31 publications

(12 citation statements)

References 10 publications

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“…8) together with ( S )-vasicinone, vasicine and deoxyvasicinone were isolated from the seeds of Peganum harmala . 57 Two ( 55 and ( S )-vasicinone) of the five compounds exhibited only weak inhibitory activity against human gastric cancer MCG-803 cells with IC 50 values of 84.1 and 94.5 μM.…”

Section: Biological Activities Of Quinoline and Quinazoline Alkaloidsmentioning

confidence: 94%

“…Two new quinazoline alkaloids (S)‐vasicinone‐1‐O‐β‐ d ‐glucopyranoside ( 55 ) and (R)‐vasicinone‐1‐O‐β‐ d ‐glucopyranoside ( 56 ) (Figure ), together with (S)‐vasicinone, vasicine, and deoxyvasicinone were isolated from the seeds of Peganum harmala . Two ( 55 and (S)‐vasicinone) of the five compounds exhibited only weak inhibitory activity against human gastric cancer MCG‐803 cells with IC 50 values of 84.1 and 94.5 μM.…”

Section: Biological Activities Of Quinoline and Quinazoline Alkaloidsmentioning

confidence: 99%

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Biologically active quinoline and quinazoline alkaloids part II

Shang

Morris‐Natschke

Yang

et al. 2018

Medicinal Research Reviews

152

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To follow-up on our prior Part I review, this Part II review summarizes and provides updated literature on novel quinoline and quinazoline alkaloids isolated during the period of 2009-2016, together with the biological activity and the mechanisms of action of these classes of natural products. Over 200 molecules with a broad range of biological activities, including antitumor, antiparasitic and insecticidal, antibacterial and antifungal, cardioprotective, antiviral, anti-inflammatory, hepatoprotective, antioxidant, anti-asthma, antitussive, and other activities, are discussed. This survey should provide new clues or possibilities for the discovery of new and better drugs from the original naturally occurring quinoline and quinazoline alkaloids.

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Section: Biological Activities Of Quinoline and Quinazoline Alkaloidsmentioning

confidence: 94%

Section: Biological Activities Of Quinoline and Quinazoline Alkaloidsmentioning

confidence: 99%

Biologically active quinoline and quinazoline alkaloids part II

Shang

Morris‐Natschke

Yang

et al. 2018

Medicinal Research Reviews

152

View full text Add to dashboard Cite

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“…Prashanth and John [35] concluded that the methanolic fraction of P. harmala found to be most effective against all tested microorganisms. Wang et al [36] discovered that methanol extracts from the seeds of P. harmala, namely, (S)-vasicinone-1-O-β-d-glucopyranoise and (S)-vasicinone exhibited moderate inhibitory activity. Phytochemicals detected in the crude extracts of P. harmala are alkaloids, terpenoids and phenols [37][38][39].…”

Section: P Harmala Nutritional Composition and Chemical Constituentsmentioning

confidence: 99%

Improving health benefits with considering traditional and modern health benefits of Peganum harmala

2021

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Background Medicinal plants are potential source of natural products that play an important role in preventing different human diseases. P. harmala is used traditionally as emmenagogue and an abortifacient agent in the Middle East, North of Africa and West of China. It belongs to the family of Zygophyllaceae and it is a wild growing flowering plant. Its seeds are main medicinal part of the plant. Methods The current searching was done by the keywords in main indexing systems including PubMed/MEDLINE, Scopus, and Institute for Scientific Information Web of Science as well as the search engine of Google Scholar. The keywords were wild rue, traditional medicine, Harman, health benefits, and pharmaceutical science. Results The most important uses of P. harmala in traditional pharmaceutical sciences are in cardiovascular, gasterointestinal, nervous, endocrine, neoplasm and tumors, pain relieving, organisms, diabetes, respiratory, disinfectant, anti-pyretic, skin and hair, rheumatism, arthritis and inflammation, and ulcers. Pharmacological effects of P. harmala are in cardiovascular system, nervous system, antimicrobial effects, antineoplasm, nervous system, endocrine, gastrointestinal effects, osteocytes, endocrine and respiratory system. Phenolic compounds are the main reason of antioxidant capacity. Conclusions Due to its pharmacological activities, P. harmala is a high potential medicinal herb and the suggestion is to increases by doing research in efficacy and safety.

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“…50 (−)-Vasicinone possesses antitumor, bronchodilating, and hypotensive activities. 51 The alkaloid deoxypeganine possesses reversible anticholinesterase activity and is used in medical practice to treat patients with peripheral nervous system diseases. 52 Boldine and other related aporphine alkaloids have been shown to possess potent antioxidant activity along with many other pharmacological activities.…”

Section: Reported Biological Activitiesmentioning

confidence: 99%

High-Throughput Detection of an Alkaloidal Plant Metabolome in Plant Extracts Using LC-ESI-QTOF-MS

et al. 2021

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Plant alkaloids represent a diverse group of nitrogen-containing natural products. These compounds are considered valuable in drug discovery and development. High-throughput identification of such plant secondary metabolites in complex plant extracts is essential for drug discovery, lead optimization, and understanding the biological pathway. The present study aims to rapidly identify different classes of alkaloids in plant extracts through the liquid chromatography with electrospray ionization-tandem mass spectrometry (LC−ESI-MS/MS) approach using 161 isolated and purified alkaloids. These are biologically important unique alkaloids belonging to different sub-classes such as isoquinoline, quinoline, indole, tropane, pyridine, piperidine, quinolizidine, aporphine, steroidal, and terpenoid. The majority of these are not available commercially and are known to manifest valuable biological activities. Four pools of a maximum of 50 phytostandards each were prepared, based on their log P value to minimize co-elution for rapid and cost-effective analyses. MS/MS spectra were acquired in the positive ionization mode by using their [M + H] + and/or [M + Na] + with both the average collisional energy (25.5−62 eV) and individual collisional energies (10, 20, 30, and 40 eV). Accurate mass, high-resolution mass spectrometry (HR-MS) data, MS/MS data, and retention times were curated for each compound. The developed LC−MS/MS method was successfully used to interrogate and fast dereplicate alkaloids in 13 medicinal plant extracts and a herbal formulation. A total of 56 alkaloids were identified based on the reference standard retention times (RTs), HR-MS spectra, and/or MS/MS spectra. The MS data have been submitted to the MetaboLights online database (MTBLS2914). The mass spectrometric and chromatographic data will be useful for the discovery of new congeners and the study of biological pathways of alkaloids in the plant kingdom.

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Antitumor quinazoline alkaloids from the seeds ofPeganum harmala

Cited by 31 publications

References 10 publications

Biologically active quinoline and quinazoline alkaloids part II

Biologically active quinoline and quinazoline alkaloids part II

Improving health benefits with considering traditional and modern health benefits of Peganum harmala

High-Throughput Detection of an Alkaloidal Plant Metabolome in Plant Extracts Using LC-ESI-QTOF-MS

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