Antitumor properties of Boswellic acid against Ehrlich ascites cells bearing mouse

Agrawal, S. S.; Saraswati, Sarita; Mathur, Rajani; Pandey, Maneesha

doi:10.1016/j.fct.2011.04.007

Cited by 73 publications

(41 citation statements)

References 43 publications

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“…Prolongation of survival is directly related to decrease in viable cell count (Agrawal et al, 2011). In the present study a significantly decreased EAC cell viability after administration of the tested extract in comparison to the control group was observed.…”

Section: Cytotoxic Activity Against Ehrlich's Tumor Cells In Micesupporting

confidence: 53%

“…The Ehrlich ascitic tumor implantation induces per se a local inflammatory reaction, with increasing vascular permeability, which results in an intense edema formation, cellular migration and progressive ascitic fluid formation (Agrawal et al, 2011). The ascitic fluid is essential for tumor growth, since it constitutes a direct nutritional source for tumor cells (De Matos Gomes et al, 2008).…”

Section: Cytotoxic Activity Against Ehrlich's Tumor Cells In Micementioning

confidence: 99%

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Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq.

Živković

Barreira

Stojković

et al. 2014

Journal of Functional Foods

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This study was designed to characterize the phenolic profile and evaluate the antibacterial, antimutagenic and antitumor activities of Veronica urticifolia Jacq. methanolic extract.HPLC-DAD/ESI-MS analysis revealed the presence of phenolic acids, flavonoids and phenylethanoids, with acteoside as the main component (14.9 mg/g of extract). Antibacterial effect was determined using the microbroth dilution assay and Staphylococcus aureus was the most sensitive strain (MIC and MBC = 7.5 mg/mL). Antimutagenic activity was evaluated by Ames mutagenicity assay. At 1 mg/plate, the tested extract afforded high protection against the mutagenicity of nitroquinoline-N-oxide (4NQO) to Salmonella typhimurium strain TA100 (inhibition rate 48.3%). Antitumor activity was screened in Ehrlich ascites carcinoma (EAC) model. Pretreatment with 2 mg/kg body weight showed statistically significant decrease in tumor cell viability, while ascites volume and tumor cell count became slightly decreased, but not to a statistically significant extent. Above results indicate that V. urticifolia deserves further research into chemoprevention.

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Section: Cytotoxic Activity Against Ehrlich's Tumor Cells In Micesupporting

confidence: 53%

Section: Cytotoxic Activity Against Ehrlich's Tumor Cells In Micementioning

confidence: 99%

Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq.

Živković

Barreira

Stojković

et al. 2014

Journal of Functional Foods

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“…All SEC in tumor-bearing mice here had measurable TNFcontent, as noted in other reports (Agrawal et al, 2011;Gomes Nde et al, 2008). Treatment of mice with PIO resulted in a significant reduction in tumor TNF-content as compared to in tumors of control mice.…”

Section: Discussionsupporting

confidence: 66%

“…By 2030, nearly 21.4 million new cancer cases -and more than 13.2 million deaths -are projected to occur worldwide (Agrawal et al, 2011). It is, therefore, essential that new therapeutic options besides the major treatment modalities (i.e., surgery, chemo-, radio-, and immunotherapy) are developed to fight cancer and to minimize potential toxicities and sideeffects of the current therapies.…”

Section: Introductionmentioning

confidence: 99%

PPARγ-dependent anti-tumor and immunomodulatory actions of pioglitazone

El‐Sisi

Sokar

Risha

2014

Journal of Immunotoxicology

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Peroxisome proliferator-activated receptor-(PPAR) has been reported to play important roles in carcinogenesis. The current study was carried out to assess the possible anti-tumor effects of pioglitazone (PIO), a PPAR agonist, in a mouse mammary carcinoma model, i.e. a solid Ehrlich carcinoma (SEC). Effects of PIO on tumor-induced immune dysfunction, and the possibility that PIO may modulate the anti-tumor and immunomodulatory effects of doxorubicin (DOX) were also studied. The effects in tumor-bearing hosts of several doses of PIO (100 mg/kg, per os), with and without the added presence of DOX (2 mg/kg, IP), was investigated in vivo; end-points evaluated included assessment of tumor volume, splenic lymphocyte profiles/functionality, tumor necrosis factor (TNF)-content, as well as apoptosis and expression of nuclear factor-B (NF-B) among the tumor cells. The data indicate that PIO induced significant anti-tumor activity against the SEC. PIO treatments also significantly mitigated both tumor-and doxorubicin-induced declines in immune parameters assessed here. Moreover, PIO led to decreased NF-B nuclear expression, and, in doing so, appeared to chemo-sensitize these tumor cells to DOX-induced apoptosis. All pioglitazone-studied effects were antagonized by GW9662, a selective PPAR antagonist.

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“…They found that the oral administration of AKBA (50-200 mg/kg) dose-dependently inhibited the growth of colorectal tumors with no adverse side effects. Other studies showed that BA and its novel cyano derivative of 11-keto-b-boswellic acid inhibited Ehrlich ascites tumor [73,74], novel 11-keto-b-boswellic acid inhibited promyelocytic leukemia cells, HL-60, in both ascites and solid tumor model, was mediated through the inhibition of topoisomerase I and II [75] and AKBA suppressed human prostate tumor xenografts in nude mice [76]. Shah et al showed that 24-NH2 substituted b-boswellic acid derivatives exhibited much more potent apoptosis induction and cell proliferation inhibition than their parent 24-COOH compounds.…”

Section: Boswellic Acidmentioning

confidence: 99%

Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer

et al. 2012

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a b s t r a c tOver the last two decades, extensive research on plant-based medicinal compounds has revealed exciting and important pharmacological properties and activities of triterpenoids. Fruits, vegetables, cereals, pulses, herbs and medicinal plants are all considered to be biological sources of these triterpenoids, which have attracted great attention especially for their potent anti-inflammatory and anti-cancer activities. Published reports in the past have described the molecular mechanism(s) underlying the various biological activities of triterpenoids which range from inhibition of acute and chronic inflammation, inhibition of tumor cell proliferation, induction of apoptosis, suppression of angiogenesis and metastasis. However systematic analysis of various pharmacological properties of these important classes of compounds has not been done. In this review, we describe in detail the pre-clinical chemopreventive and therapeutic properties of selected triterpenoids that inhibit multiple intracellular signaling molecules and transcription factors involved in the initiation, progression and promotion of various cancers. Molecular targets modulated by these triterpenoids comprise, cytokines, chemokines, reactive oxygen intermediates, oncogenes, inflammatory enzymes such as COX-2, 5-LOX and MMPs, anti-apoptotic proteins, transcription factors such as NF-jB, STAT3, AP-1, CREB, and Nrf2 (nuclear factor erythroid 2-related factor) that regulate tumor cell proliferation, transformation, survival, invasion, angiogenesis, metastasis, chemoresistance and radioresistance. Finally, this review also analyzes the potential role of novel synthetic triterpenoids identified recently which mimic natural triterpenoids in physical and chemical properties and are moving rapidly from bench to bedside research.

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Antitumor properties of Boswellic acid against Ehrlich ascites cells bearing mouse

Cited by 73 publications

References 43 publications

Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq.

Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq.

PPARγ-dependent anti-tumor and immunomodulatory actions of pioglitazone

Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer

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