Antitumor Polysaccharides from Some Polyporaceae, Ganoderma applanatum (PERS.) PAT and Phellinus linteus (BERK. et CURT) AOSHIMA

Sasaki, Takuma; Arai, Yasuo; Ikekawa, Tetsuro; Chihara, Goro; Fukuoka, Fumiko

doi:10.1248/cpb.19.821

Cited by 48 publications

(15 citation statements)

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“…These preparations had antitumor properties against transplanted sarcoma-180 in mice, and, for one of the obtained fractions, a complete regression of tumors was observed in more than half of animals; inhibition ratios were over 95%, with no sign of toxicity (Sazaki et al, 1971). These fractions were considered to be a glucan consisting partially of a mixture of β-(1→3) and (1→4) linked D-glucose residues.…”

Section: Ganoderma Polysaccharidic Extracts/fractionsmentioning

confidence: 98%

Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities

et al. 2015

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This review aims to contribute to the growing knowledge on bioactive (antioxidant, antitumor and antimicrobial) properties of polysaccharides, glycoproteins and polysaccharidic extracts obtained from Ganoderma species. The chemical features were analyzed and related to correspondent bioactivities. ____________________________________________________________________ 2 Research highlightsChemical features of Ganoderma bioactive polysaccharides were discussed.Methods for extraction, isolation and identification were evaluated.Bioactivity of polysaccharidic extracts and purified compounds were discussed.Integration of data allowed deduction of structure-activity relationships.

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Section: Ganoderma Polysaccharidic Extracts/fractionsmentioning

confidence: 98%

Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities

et al. 2015

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“…Previous investigations dealing with the sugar composition of IWSPB samples (Table I, [6--19]), provided qualitative information only. Either the peak area [6][7][8][11][12][13][14] or the mole ratios [9,10,[16][17][18] of the simple sugars were reported. The organic and the o-phosphoric acid contents of selected IWSPB samples, for the time being have not been measured (Table V).…”

Section: Resultsmentioning

confidence: 99%

“…The isolation of the glycoprotein fraction of the fruiting body has been given in detail in patents [3][4][5]. The sugar composition of the anticarcinogenic glycoprotein fractions was identified (not determined) in different hydrolyzates [6][7][8][9][10][11][12][13][14][15][16][17][18][19] obtained with sulphuric [6--9,12-17], formic [11] TFA [10,18] and methanolic hydrochloric [19] acids in various concentrations (Table I). The aim of this work was (i) to optimize the hydrolysis and the GC/MS conditions of the immunostimulant water-soluble polysaccharides of Basidiomycetes (IWSPB) in order (ii) to identify and quantitate the widest variety of simple constituents in maximum yield.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous GC-MS quantitation of acids and sugars in the hydrolyzates of immunostimulant, water-soluble polysaccharides of basidiomycetes

et al. 1998

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SummaryThe simultaneous quantitation of acids and sugars as their trimethyl silyl (TMS) derivatives has been extended in order to identify and quantitate the simple acid and sugar constituents in the hydrolyzates of various immunostimulant, water-soluble polysaccharides obtained from various Basidiomycetes, such as Armillariella mellea, Auricularia auricula-judae, Coriolus versicolor, Flammulina velutipes, Fomes fomentarius, Ganoderma applanatum, Ganoderma lucidum, Pleurotus ostreatus, Schizophyllum commune, Trametes hirsuta. Optimum hydrolysis conditions, performed with 2 M trifluoroacetic acid (TFAA) for five hrs, proved the presence of several sugars and acids with maximum recovery. (i) The total sugar/sugar alcohol content of polysaccharides varied between 20-and 65 % and consisted of arabitol (0.01-10.2 %), arabinose (0.09-1.3 %), ribose (0.2-1.8 %), fucose (0.3-1.2 %), mannitol (0.01-5.3 %), sorbitol (0.01-0.05 %), galactitol (0.04 %), fructose (0.08-0.8 %), galactose (0.9-29 %), glucose (10-53 %), uronic acids (0.14-3.7 %), sucrose (0.03-2 %), trehalose (0.2-1%), cellobiose 0.01-0.6 %), maltose 0.2-1.9 %), other disaccharides (0.2-8 %). (ii) The total of acids varied from 1.5 to 30 % including o-phosphoric (1.3-19 %), malic (0.08--4.7 %), citric (0.08-4.7 %), isocitric; (3 %) and C16-C18 fatty acids (1-6 %).

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“…Especially, it shows prominent anti-tumor actions. In the 70s, T. Sasaki uncovered the antitumor effect of polysaccharides from Ganoderma applanatum (another species of Ganoderma) for the first time (6). From then on, both in vivo and in vitro research on the anti-tumor activity of Ganoderma lucidum have been carried out, supporting its application for cancer treatment and prevention.…”

Section: Introductionmentioning

confidence: 99%

Serum amyloid A mediates the inhibitory effect of Ganoderma lucidum polysaccharides on tumor cell adhesion to endothelial cells

Wang²,

Wu³

et al. 1994

Oncol Rep

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Abstract. Ganoderma ludicum polysaccharides (GlPS) are the major bioactive composition of Ganoderma lucidum, a well-recognized oriental medical fungus. The published data have shown a complementary effect of GlPS in cancer therapy. The present study was designed to determine the anti-tumor efficacy of GlPS and the possible mechanism covering this effect. Murine Sarcoma 180 (S180) model was established, and GlPS administered orally for 10 days. On the 10th day, tumors were weighed to assess the inhibitory effect of GlPS and sera were collected for proteomic analysis and in vitro study. The in vivo results demonstrated that 25, 50 and 100 mg/kg GlPS inhibited S180 growth by 32.67, 44.80 and 45.24%, respectively (P<0.01). Proteomic study revealed marked protein changes after the process of treatment. Three significantly changed proteins were identified by ESI-Q-TOF-MS and database search indicated that they were haptoblobin, apolipoprotein A-II and serum amyloid A (SAA), respectively. Additionally, the expression change of SAA was confirmed by both Western blot and RT-PCR. The adhesion assay showed that GlPS-treated sera dramatically inhibited the adhesion ability of human prostate carcinoma (PC-3M) cells to human umbilical cord vascular endothelial cells (HUVECs), and this effect partially recovered after immunodepletion by the antibody against SAA. Collectively, these results suggest that GlPS inhibited the tumor growth and tumor cell adhesion to HUVECs via up-regulation of SAA protein expression.

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Antitumor Polysaccharides from Some Polyporaceae, Ganoderma applanatum (PERS.) PAT and Phellinus linteus (BERK. et CURT) AOSHIMA

Cited by 48 publications

References 0 publications

Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities

Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities

Simultaneous GC-MS quantitation of acids and sugars in the hydrolyzates of immunostimulant, water-soluble polysaccharides of basidiomycetes

Serum amyloid A mediates the inhibitory effect of Ganoderma lucidum polysaccharides on tumor cell adhesion to endothelial cells

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