Antitumor mechanism of Se-containing polysaccharide, a novel organic selenium compound

Abstract

Recent studies on the inhibition of tumor growth by Se-containing polysaccharide were reviewed. Meanwhile, the possible molecular mechanisms of the inhibition of tumor cell growth through antioxidation, induction of tumor cell apoptosis, blockade of cell cycle, and enhancement of immunity by Se-containing polysaccharide were proposed. In the end, the potential application of Se-containing polysaccharide in the prevention and treatment of tumor was elucidated.

Structural modification and biological activities of carboxymethyl Pachymaran

“…Metal ions can react with the hydroxyl and carboxyl groups of polysaccharides to form complexes or esters (Liao et al., 2015 ; Liu, Yin, et al., 2019 ; Liu, Liu, et al., 2019 ; Moe et al., 2019 ). Polysaccharide zinc, polysaccharide selenium, and polysaccharide iron enhance the inhibition mediated by polysaccharides on hepatoma cells, breast cancer cells, and colon cancer cells (Deng et al., 2009 ; Ding et al., 2019 ; Liao et al., 2015 ; Shang et al., 2009 ). At the same time, compared with inorganic metal patches with considerable side effects, organic metal patches have fewer side effects.…”