Antitumor Effects of Sorbus aucuparia L. Extract Highly Saturated with Anthocyans and Their Mechanisms

Разина, Т. Г.; Зуева, Е. П.; Ulrich, A-K; Rybalkina, O. Yu.; Chaikovskii, A. V.; Исайкина, Н. В.; Калинкина, Г. И.; Zhdanov, V. V.; Zyuz’kov, G. N.

doi:10.1007/s10517-016-3554-4

Cited by 18 publications

(12 citation statements)

References 10 publications

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“…Sorbus fruits (rowanberries) are unique fruits with a rich composition of phytocompounds of various chemical origin [ 4 , 8 , 12 ]. Currently, more knowledge regarding the phytocomposition and health effects of Sorbus fruits is emerging [ 8 , 25 ], although these health promoting fruits are still underrated. Promotion of Sorbus species and incorporating their fruits in food and pharmaceutical industries could address the consumer’s concerns over the safety and functionality of foods and health promoting supplements, as Sorbus plants are easily cultivated and are appropriate for areas with lower temperatures and poor soil environments [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Profiling of Fruit Powders of Twenty Sorbus L. Cultivars

et al. 2018

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Rowanberries have been traditionally used in various processed foods. Scientific research demonstrates the pharmacological effects of Sorbus L. fruits are determined by their unique composition of biologically active compounds. The aim of this study was to determine the composition of flavonoids, phenolic acids, anthocyanins, carotenoids, organic acids and sugars as well as the total antioxidant activity in fruit powders of 20 Sorbus cultivars. Chemical profiles of rowanberry fruit powders vary significantly. Cultivars ‘Burka’, ‘Likernaja’, ‘Dodong’, and ‘Fructo Lutea’ distinguish themselves with exclusive phytochemical composition and high antioxidant activity. Fruit powders from ‘Burka’, ‘Likernaja’ contain the highest contents of anthocyanins while fruit powder samples from ‘Fructo Lutea’ and ‘Dodong’ contain the highest levels of phenolic acids, ascorbic acid and the lowest levels of fructose. Fruit powder samples from ‘Dodong’ also contain the highest levels of β-carotene and sorbitol and the lowest levels of malic acid. Cultivars ‘Burka’, ‘Likernaja’, ‘Dodong’, and ‘Fructo Lutea’ could be selected as eligible raw materials for the preparation of rowanberry fruit powders.

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Section: Discussionmentioning

confidence: 99%

Phytochemical Profiling of Fruit Powders of Twenty Sorbus L. Cultivars

et al. 2018

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“…It is evident that among phytochemicals and other nutrients, polyphenolic compounds and ascorbic acid may be considered as the most valuable health beneficial constituents, which have been reported in various anatomical parts of Sorbus spp. The polyphenolics, which may influence the colour and flavour, have demonstrated antioxidant [54,81], antidiabetic [11,82] anti-hyperlipidemic [83], anti-inflammatory [84], antimicrobial [85], anticancer [86,87] antiviral [67], antifungal [79], antitumoral [88], anti-periodontal [89], and anti-osteoarthritis [90] effects, as well as vasoprotective [84], neuroprotective [26,91,92], cardioprotective [36], hepatoprotective [7], properties and COX-2 (cyclooxygenase-2) inhibitory [93] activities. Many of these activities are correlated to antioxidant capacity of bioactive compounds, which at cellular level may neutralize excessive reactive oxygen species, and thereby protect important biomolecules in the conditions of oxidative stress, which can cause cellular injury and development of chronic diseases.…”

Section: Promising Health Benefits and Related Applications In Foodsmentioning

confidence: 99%

The Sorbus spp.—Underutilised Plants for Foods and Nutraceuticals: Review on Polyphenolic Phytochemicals and Antioxidant Potential

2020

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The Sorbus spp. are valuable plants, which have been used for ornamental purposes, in traditional medicines and less seldom in foods. Recent studies have revealed different anatomical parts of the Sorbus spp. to contain valuable phytochemicals demonstrating various bioactivities. However, in terms of applications in the products intended for human consumption, Sorbus still remains as an underutilised genus. The increasing number of studies on phytochemicals, antioxidant potential and other bioactivities of Sorbus extracts has revealed the prospects of expanding its use in natural medicines, cosmetics and as innovative food ingredients, which might find wider applications in functional foods and/or nutraceuticals. Caffeoylquinic acids, flavonoids and proanthocyanidins have been reported in various Sorbus spp. as the most abundant polyphenolic antioxidants. The preparations of various plant anatomical parts have been used in ethnopharmacology as natural remedy for treating bacterial, viral, inflammatory diseases including tumors. Sorbus spp. plant parts have also been tested for management of diabetes, neurological, and cardiovascular disorders. The present review is focused on Sorbus plants (in total 27 Sorbus spp.), their composition and properties in terms of developing promising ingredients for foods, nutraceutical, cosmeceutical and other applications. It is expected that this review will assist in designing further studies of rowans and other Sorbus spp. in order to expand their uses for various human applications.

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“…The IC 50 values of all extracts ranged from 414 ± 12.5 to 965 ± 27.9 lg/mL and no selectivity of action was noted (podophyllotoxin, IC 50 values from (1.30 ± 0.20) 9 10 -3 to (4.70 ± 0.80) 9 10 -3 ). Razina et al (2016) examined in vivo antitumor activity of acidified 95% ethanol extract from S. aucuparia fruits standardized on anthocyanins. This extract was given to female C57BL/6 mice with intramuscularly transplanted melanoma B-16 and Lewis lung carcinoma cells (5 9 10 6 cells/0.1 mL saline).…”

Section: Cytotoxic Activitymentioning

confidence: 99%

Ethnopharmacologically important but underestimated genus Sorbus: a comprehensive review

2020

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Sorbus L. sensu lato (Rosaceae family) comprises over 250 trees and shrubs growing in the Northern Hemisphere. Several Sorbus species have found their way into traditonal materia medica, as different leaf, bark or fruit preparations have a longstanding folk use. Ethnomedicine recommends their use not only in respiratory and gastrointestinal system disorders, but also in rheumatism, cancer or diabetes. Chemical composition of the genus Sorbus has been studied since 1960s and until now more than 250 compounds have been identified from thirty-eight species. The most thoroughly investigated substances are phenolic compounds (flavonoids and phenolic acids). Other constituents include triterpenes, sterols, carboxylic acids, coumarins and cyanogenic glycosides. Biological activity studies performed on the representatives of the genus Sorbus have been predominantly conducted on extracts prepared with the use of different solvents, and more rarely on isolated constituents. The majority of these studies were devoted to determination of antioxidant potential of Sorbus extracts. In a few cases targeted studies were conducted to confirm specific folk usage. Two of the fairly well documented medicinal uses are the antidiabetic activity of Sorbus decora and antiinflammatory activity of Sorbus commixta. Keywords Sorbus Á Folk medicine Á Phytochemistry Á Biological activity Abbreviations AAPH 2,2 0 -Azobis-(2-amidinopropane) dihydrochloride ABTS 2,2 0 -Azino-bis(3-ethylbenzothioazoline-6sulphonic acid) diammonium salt ACE Angiotensin converting enzyme AChE Acetylcholinesterase ADH Alcohol dehydrogenase ALT Alanine aminotransferase AMPK Adenosine-monophosphate-activated protein kinase AST Aspartate transaminase ATO Arsenic trioxide BChE Butyrylcholinesterase CAT Catalase CD Conjugated dienes cGMP Guanosine 3 0 ,5 0 -cyclic monophosphate COX-2 Cyclooxygenase-2 CYP Cytochrome P450 DMPD ? N,N-Dimethyl-p-phenylenediamine DPPH 2,2 0 -Diphenyl-1-picrylhydrazyl dw Dry weight ecNOS Endothelial cell NO synthase EDTA Ethylenediamine tetraacetic acid

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Antitumor Effects of Sorbus aucuparia L. Extract Highly Saturated with Anthocyans and Their Mechanisms

Cited by 18 publications

References 10 publications

Phytochemical Profiling of Fruit Powders of Twenty Sorbus L. Cultivars

Phytochemical Profiling of Fruit Powders of Twenty Sorbus L. Cultivars

The Sorbus spp.—Underutilised Plants for Foods and Nutraceuticals: Review on Polyphenolic Phytochemicals and Antioxidant Potential

Ethnopharmacologically important but underestimated genus Sorbus: a comprehensive review

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