Antitumor Effects of Chelerythrine:  A Literature Review

Kang, Kai; Jiang, Hong-Min; Zhang, Shujun; Cheng, Binglin

doi:10.1177/1934578x221103028

Cited by 3 publications

(3 citation statements)

References 52 publications

(67 reference statements)

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“…Although it is currently the focal point in antitumour research and its effect has been approved in prostate cancer, cervical cancer, gastric cancer cells, non-small cell lung carcinoma, renal cell carcinoma, etc. [ 37 ], little research has been performed on AML. The findings of our study provide new strategies for treating AML, and further studies are needed to confirm the pharmacological mechanism of chelerythrine in this disease.…”

Section: Discussionmentioning

confidence: 99%

High FAAP24 expression reveals poor prognosis and an immunosuppressive microenvironment shaping in AML

et al. 2023

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Background As a core member of the FA complex, in the Fanconi anemia pathway, FAAP24 plays an important role in DNA damage repair. However, the association between FAAP24 and patient prognosis in AML and immune infiltration remains unclear. The purpose of this study was to explore its expression characteristics, immune infiltration pattern, prognostic value and biological function using TCGA-AML and to verify it in the Beat AML cohort. Methods In this study, we examined the expression and prognostic value of FAAP24 across cancers using data from TCGA, TARGET, GTEx, and GEPIA2. To further investigate the prognosis in AML, development and validation of a nomogram containing FAAP24 were performed. GO/KEGG, ssGSEA, GSVA and xCell were utilized to explore the functional enrichment and immunological features of FAAP24 in AML. Drug sensitivity analysis used data from the CellMiner website, and the results were confirmed in vitro. Results Integrated analysis of the TCGA, TARGET and GTEx databases showed that FAAP24 is upregulated in AML; meanwhile, high FAAP24 expression was associated with poor prognosis according to GEPIA2. Gene set enrichment analysis revealed that FAAP24 is implicated in pathways involved in DNA damage repair, the cell cycle and cancer. Components of the immune microenvironment using xCell indicate that FAAP24 shapes an immunosuppressive tumor microenvironment (TME) in AML, which helps to promote AML progression. Drug sensitivity analysis showed a significant correlation between high FAAP24 expression and chelerythrine resistance. In conclusion, FAAP24 could serve as a novel prognostic biomarker and play an immunomodulatory role in AML. Conclusions In summary, FAAP24 is a promising prognostic biomarker in AML that requires further exploration and confirmation.

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Section: Discussionmentioning

confidence: 99%

High FAAP24 expression reveals poor prognosis and an immunosuppressive microenvironment shaping in AML

et al. 2023

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“…Sanguinarine (2), for instance, exhibits potent antimicrobial activity against a range of pathogens, including bacteria, fungi, protozoa, and other relevant biological properties [9]. Chelerythrine (3) has shown capacity as an anticancer agent by inducing apoptosis in cancer cells [10] and even antifungal action [11]. The diverse bioactivities of these alkaloids highlight the potential for developing new drugs and therapeutic agents based on the discovery of bioactive benzophenanthridines [12].…”

Section: Introductionmentioning

confidence: 99%

N-Methoxycarbonyl-9,12-Dimethoxy-Norchelerythrine: A Novel Antifungal Type-III Benzo[c]phenanthridine from Zanthoxylum simulans Hance Seedlings

Cárdenas-Laverde,

Quiroga,

Coy-Barrera

2024

Molbank

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Zanthoxylum simulans Hance, commonly known as Sichuan pepper, is a well-known medicinal plant recognized for its potential as a source of bioactive specialized metabolites. As part of our interest in natural antifungal compounds, the present study describes the discovery of an unreported N-alcoxycarbonylbenzo[c]phenanthridinium salt, N-methoxycarbonyl-9,12-dimethoxy-norchelerythrine 1 (a type-III benzo[c]phenanthridine), isolated from Z. simulans seedlings, which were propagated under controlled greenhouse conditions. Six-month seedlings were harvested and subjected to cold acid–base extraction. Chromatographic techniques achieved the isolation of 1 from raw alkaloid extract. The structural elucidation of 1 was accomplished through comprehensive spectroscopic analysis, including nuclear magnetic resonance and high-resolution mass spectrometry. Fusarium oxysporum, a fungal pathogen responsible for substantial agricultural losses, was exposed to different concentrations of the novel compound, exhibiting potent antifungal efficacy (IC50 < 3 µM) and fungicide effects. These findings highlight the potential of benzophenanthridines as antifungal leads and underscore the importance of exploring natural products for agricultural applications.

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“…6 Among the origin of homeopathic medicines are those of plant origin, which have established use for treating various diseases and their undeniable scientific evidence as herbal medicines. Based on this knowledge and the Homeopathic Medical Matter, Chelidonium majus (Papaveraceae family), originating in the European continent, is indicated in cases of liver diseases, usually accompanied by severe local pain and jaundice, among other clinical signs 7 . Furthermore, according to NAWAZ et al This study evaluated the effect of the D35 (1x10 -35 ) homeopathic dilution of Chelidonium majus in hepatocellular carcinoma cells (HepG2) after cell culturing and treatment with this medicine, using the MTT in vitro cell viability test.…”

Section: Introductionmentioning

confidence: 99%

Cell Viability Assessment by MTT After Treatment of Hepatocellular Carcinoma Cells (HepG2) with Chelidonium majus

Valle,

Carvalho,

Rahme

et al. 2023

MRAJ

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Hepatocellular carcinoma is a type of cancer with a high mortality rate since it is primarily diagnosed in an advanced stage. Therefore, searching for therapies that help in this treatment becomes increasingly important. Therapies comprising Complementary Medicine have become more popular and have shown beneficial effects in treating various types of cancer. Homeopathy, a therapy established for more than 200 years to treat various diseases, has become the target of several studies, especially regarding chronic diseases, which are difficult to control by conventional medicine. This study evaluated the effect of the homeopathic dilution of Chelidonium majus D35 (1x10-35) in hepatocellular carcinoma cells (HepG2). Cells were cultivated in an oven at 37 ºC, 5% CO2, and then trypsinized and plated in 96-well plates for product addition. Chelidonium majus D35 was added in triplicate to each well at three different concentrations. The concentrations tested were 20, 40, and 60 µL/mL. After 48 hours of incubation with the product, cell viability was measured by MTT, and it was possible to observe a decrease in the groups that received the treatment compared to the control. A decrease in cell viability was recorded compared to the control of cells without treatment, indicating a cytotoxic effect of Chelidonium majus D35 on tumor cells. Different studies confirm this result due to the evaluation of biologically active compounds present in extracts of Chelidonium majus D35 that control cell proliferation and induce apoptosis. The results of the in vitro tests performed were satisfactory.

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Antitumor Effects of Chelerythrine: A Literature Review

Cited by 3 publications

References 52 publications

High FAAP24 expression reveals poor prognosis and an immunosuppressive microenvironment shaping in AML

High FAAP24 expression reveals poor prognosis and an immunosuppressive microenvironment shaping in AML

N-Methoxycarbonyl-9,12-Dimethoxy-Norchelerythrine: A Novel Antifungal Type-III Benzo[c]phenanthridine from Zanthoxylum simulans Hance Seedlings

Cell Viability Assessment by MTT After Treatment of Hepatocellular Carcinoma Cells (HepG2) with Chelidonium majus

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