Antitumor Effect of Oxycellulose as a Hemostatic during Operation

Abstract

Oxycellulose, a hemostatic agent used in operation showed antitumor effect in vitro on a murine hepatic cell carcinoma (MH 134), a murine fibrosarcoma (Meth A) and a murine colon carcinoma (Colon 26). The effect was also confirmed in vivo by the survival of mice inoculated with Meth A or MH 134. Eighty milligrams per mouse of this agent, however, showed a toxicity rather than an antitumor effect. The antitumor effect of oxycellulose on Meth A did not compare with that of etoposide or mitomycin C in vivo. The antitumor effect on MH 134 was equal to that of etoposide but not mitomycin C. Oxycellulose inhibited tritium thymidine uptake into Colon 26 cells to the same extent as 5-fluorouracil and mitomycin C and it caused 51Cr-labelled Colon 26 cells but not from 5-fluorouracil or mitomycin C. Oxycellulose decreased a larger number of viable tumor cells than 5-fluorouracil or mitomycin C when the tumor cells were incubated for 24 hours at 37 degrees C. DNA histogram with MH 134 cells showed oxycellulose decreased a ratio of tumor cells in S-phase. These results suggest that the antitumor effect of oxycellulose is cytocidal and phase-specific.

Synthesis and Characterization of Novel Integral Asymmetric Monophasic Cellulose–Acetate/Silica/Titania and Cellulose–Acetate/Titania Membranes

“…Cellulose’s most significant industrial ester, cellulose acetate (CA), is formed by the acetylation of cellulose, followed by acid-hydrolysis, to lower the acetyl degree ( Figure 1 b). Though this process modifies the original cellulose biostability, CA is generally recognized as a biodegradable [ 1 , 2 ], biocompatible and (re)absorbable thermoplastic polymer [ 3 , 4 , 5 ]. Properties such as excellent hydrophilicity, good resistance to chlorine and other oxidant compounds, non-toxicity, non-irritancy, great mechanical flexibility and reasonable heat-resistance, along with low footprint and cost make CA a pivotal raw material in a wide range of traditional industries [ 6 ].…”

Adsorption of zwitterionic drugs onto oxidized cellulose

“…It is one of the most widespread hemostatics, used in almost all types of surgery. OC has been shown to possess antitumor [4], immunostimulant [5], wound-healing [6], and adhesion-prevention properties [7,8]. The presence of carboxyl groups at C6 in OC permits the immobilization of drugs by adsorption [9] and preparation of polymer drugs with a variety of therapeutic effects.…”

Examination of aqueous oxidized cellulose dispersions as a potential drug carrier. I. Preparation and characterization of oxidized cellulose-phenylpropanolamine complexes

“…4 It is currently used in humans as a hemostatic agent and as a postsurgical adhesion barrier. 5 Studies also show that it possesses antibacterial, 6 antitumor, 7 and immunostimulant 8 properties. Owing to the presence of free carboxylic acid groups, OC is also useful as an immobilizing matrix for drugs, enzymes, and proteins.…”