Antitumor effect of invasive Lactobacillus plantarum delivering associated antigen gene sHSP between Trichinella spiralis and Lewis lung cancer cells

Yue, Taotao; Zhang, Xichen; Gong, Pengtao; Li, Jianhua; Wang, Xiaocen; Li, Xin; Ma, Yeting; Chen, Xuejiao; Zhang, Xu; Cheng, Shuqin; Zhang, Nan

doi:10.1016/j.intimp.2023.109708

Cited by 5 publications

(1 citation statement)

References 47 publications

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“…The distribution and abundance of specific postbiotic molecules offer valuable insights into the functional properties of these strains, positioning them as potential probiotics. Recent research has highlighted the potential of L. plantarum as a carrier for vaccines, offering an exciting avenue for developing anti-tumor vaccines using food-grade microorganisms [52].…”

Section: Discussionmentioning

confidence: 99%

Exploring Phenotype, Genotype, and the Production of Promising GABA Postbiotics by Lactiplantibacillus plantarum: A Comprehensive Investigation

Abdel-motaal,

Abdelazez,

Wang

et al. 2024

Fermentation

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This study aims to investigate the probiotic properties of various isolated strains of Lactiplantibacillus plantarum. Specifically, the focus is on examining the expression of the glutamic acid decarboxylase (GAD) gene and its role in the production of gamma-aminobutyric acid (GABA), a promising postbiotic metabolite. The investigation includes comprehensive analyses of morphology, genetics, resilience against bile, NaCl, and simulated pancreatin juice (SPJ), carbohydrate fermentation patterns, antibacterial activity, susceptibility to antibiotics, and the presence of β-D-galactosidase and GAD enzymes. Six L. plantarum strains exhibited remarkable resilience against bile, NaCl, and SPJ, as well as susceptibility to antibiotics and antagonistic behavior against pathogens. These strains also showed the presence of β-D-galactosidase. Additionally, five L. plantarum strains were found to harbor the gad gene. Further biochemical analysis of four specific L. plantarum strains revealed promising profiles consisting of antibiotics, vitamins, hormones, and a diverse array of metabolites with potential immunotherapeutic properties. This study highlights the substantial potential of Lactiplantibacillus plantarum in generating beneficial postbiotic metabolites. The identified strains offer exciting avenues for further exploration, with potential applications in functional foods and pharmaceuticals. This research opens up possibilities for harnessing the probiotic and postbiotic potential of L. plantarum to develop novel products with health-promoting properties.

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Section: Discussionmentioning

confidence: 99%

Exploring Phenotype, Genotype, and the Production of Promising GABA Postbiotics by Lactiplantibacillus plantarum: A Comprehensive Investigation

Abdel-motaal,

Abdelazez,

Wang

et al. 2024

Fermentation

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Effect of millets and probiotics on cancer prevention:exploring its nutritional composition and health benefits

2024

Curr. Pharmacol. Rep.

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Promising dawn in tumor microenvironment therapy: engineering oral bacteria

Wang,

Sun,

Hua

et al. 2024

Int J Oral Sci

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Despite decades of research, cancer continues to be a major global health concern. The human mouth appears to be a multiplicity of local environments communicating with other organs and causing diseases via microbes. Nowadays, the role of oral microbes in the development and progression of cancer has received increasing scrutiny. At the same time, bioengineering technology and nanotechnology is growing rapidly, in which the physiological activities of natural bacteria are modified to improve the therapeutic efficiency of cancers. These engineered bacteria were transformed to achieve directed genetic reprogramming, selective functional reorganization and precise control. In contrast to endotoxins produced by typical genetically modified bacteria, oral flora exhibits favorable biosafety characteristics. To outline the current cognitions upon oral microbes, engineered microbes and human cancers, related literatures were searched and reviewed based on the PubMed database. We focused on a number of oral microbes and related mechanisms associated with the tumor microenvironment, which involve in cancer occurrence and development. Whether engineering oral bacteria can be a possible application of cancer therapy is worth consideration. A deeper understanding of the relationship between engineered oral bacteria and cancer therapy may enhance our knowledge of tumor pathogenesis thus providing new insights and strategies for cancer prevention and treatment.

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Antitumor effect of invasive Lactobacillus plantarum delivering associated antigen gene sHSP between Trichinella spiralis and Lewis lung cancer cells

Cited by 5 publications

References 47 publications

Exploring Phenotype, Genotype, and the Production of Promising GABA Postbiotics by Lactiplantibacillus plantarum: A Comprehensive Investigation

Exploring Phenotype, Genotype, and the Production of Promising GABA Postbiotics by Lactiplantibacillus plantarum: A Comprehensive Investigation

Effect of millets and probiotics on cancer prevention:exploring its nutritional composition and health benefits

Promising dawn in tumor microenvironment therapy: engineering oral bacteria

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