Antitumor effect of exopolysaccharide from Lactiplantibacillus plantarum WLPL09 on melanoma mice via regulating immunity and gut microbiota

Wang, Qi'an; Jiang, Bensheng; Wei, Min; He, Yao; Wang, Yujie; Zhang, Qimeng; Wei, Hua; Tao, Xueying

doi:10.1016/j.ijbiomac.2023.127624

Cited by 4 publications

(2 citation statements)

References 56 publications

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“…Recently, Zhou et al genetically engineered E. coli Nissle 1917 (ECN) to express antioxidant enzymes (catalase and superoxide dismutase) for the treatment of IBD [13]. The EPSs produced by probiotics have also been reported along with antitumor and anti-inflammatory activities in melanoma mice [14]. Finally, Piewngam et al discovered that fengycin, a peptide secreted by Bacillus subtilis, competitively inhibits the AgrC receptor in the quorum-sensing system of Staphylococcus aureus, thereby suppressing the proliferation of S. aureus [15].…”

Section: Production Of Bioactive Compoundsmentioning

confidence: 99%

The Potential of Probiotics in Disease Treatment: Mechanisms, Engineering, and Applications

Liu,

Chen,

Dharmasiddhi

et al. 2024

Preprint

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Probiotics, living microorganisms with demonstrated health benefits when administered in sufficient quantities, have a rich history as dietary supplements to benefit human health. Recently, understanding of their mechanisms in the gastrointestinal tract has prompted exploration of probiotics in treating human diseases. However, the effective and precise delivery of probiotics remains a significant challenge in therapeutic applications. Here, we review the mechanisms of action of probiotics in human health and the most advanced strategies for efficient probiotic delivery. We also discuss the potential applications of engineered probiotics in disease treatment. This review contributes insights into the evolving landscape of probiotic research for therapeutic applications.

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Section: Production Of Bioactive Compoundsmentioning

confidence: 99%

The Potential of Probiotics in Disease Treatment: Mechanisms, Engineering, and Applications

Liu,

Chen,

Dharmasiddhi

et al. 2024

Preprint

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show abstract

“…Extracellular polysaccharides (BBE) isolated from Bifidobacterium breve are able to alleviate colitis by restoring the balance of the intestinal microbiota and increasing occludin, claudin-1 and ZO-1 expression, and mucin content [ 6 ]. It is likely that EPS-09 from L. plantarum WLPL09 could adjust the composition of the intestinal microbiota (such as increase the abundance of phylum Firmicutes and lower the abundance of genus Akkermansia ) and upregulate the transcription of apoptosis-related genes for inhibiting melanoma-bearing mice tumors [ 7 ]. The EPSs generated from L. mesenteroides XR1 consist of glucose and galactose, which contribute to a higher viscosity, elasticity, and water retention in fermented milk, which could be an alternative to xanthan gum in food additives [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Glucans with Different Degrees of Polymerization from Leuconostoc mesenteroides CICC6055: Analysis of Physicochemical Properties and Intestinal Prebiotic Function

Gu,

Jiao,

Wang

et al. 2023

IJMS

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This study explored the physicochemical properties and prebiotic activities of glucans and oligoglucans. Oligoglucans were obtained through the fermentation of Leuconostoc mesenteroides CICC6055 and the glucansucrase of strain CICC6055, while glucans were obtained only through fermentation. Thin-layer chromatography and high-performance liquid chromatography identified enzymatically synthesized oligoglucans with a higher yield. Differential scanning calorimetry and derivative thermogravimetry analyses revealed the heat resistance of the glucans and oligoglucans at 280–300 °C. Fourier transform-infrared spectroscopy and nuclear magnetic resonance analyses demonstrated that their main chains were linked with α-1,6-glycosidic bonds accompanied by glucose residue branching. In vitro fermentation experiments demonstrated that they not only improved the contents of short-chain fatty acids but also raised the abundance of predominant flora, such as Bacteroides, Firmicutes, Verrucomicrobia, and Proteobacteria. These results implicate glucansucrase as an efficacious tool for the enzyme synthesis of oligoglucans. Furthermore, both polysaccharides with different degrees of polymerization may be beneficial in maintaining a healthy human gut.

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Microbial exopolysaccharides: Unveiling the pharmacological aspects for therapeutic advancements

Akhtar,

Wani,

Sharma

et al. 2024

Carbohydrate Research

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Antitumor effect of exopolysaccharide from Lactiplantibacillus plantarum WLPL09 on melanoma mice via regulating immunity and gut microbiota

Cited by 4 publications

References 56 publications

The Potential of Probiotics in Disease Treatment: Mechanisms, Engineering, and Applications

The Potential of Probiotics in Disease Treatment: Mechanisms, Engineering, and Applications

Glucans with Different Degrees of Polymerization from Leuconostoc mesenteroides CICC6055: Analysis of Physicochemical Properties and Intestinal Prebiotic Function

Microbial exopolysaccharides: Unveiling the pharmacological aspects for therapeutic advancements

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