Antitumor effect of 22-oxa-1α,25-dihydroxyvitamin D3 a potent angiogenesis inhibitor, on rat mammary tumors induced by 7, 12-dimethylbenz[a]anthracene

Oikawa, Tsutomu; Yoshida, Y.; Shimamura, Mariko; Ashino-Fuse, Hiromi; Iwaguchi, Takao; Tominaga, Takeshi

doi:10.1097/00001813-199110000-00007

Cited by 59 publications

(16 citation statements)

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“…For tumor suppressive activity, besides growth inhibition, vitamin D and its analogues decrease the invasiveness of several cell types in vitro, and they inhibit angiogenesis and metastasis in xenograft and transgenic mouse models in vivo (58,59). In cultured malignant cells, 1a,25(OH) 2 D 3 and its analogues down-regulate cell invasion-associated proteases include matrix metalloproteinases 2 and 9 (60, 61) and serine proteinases (62).…”

Section: Invasion and Metastasismentioning

confidence: 99%

“…Moreover, the beneficial effects of 22-oxa-1a,25(OH) 2 D 3 on breast cancer can be augmented by combination with the antiestrogen, tamoxifen, or an aromatase inhibitor (73,74). Suppression of tumor growth by 22-oxa-1a,25(OH) 2 D 3 was accompanied by inhibiting neovascularization (58,67). An additional benefit of EB1089 and 22-oxa-1a,25(OH) 2 D 3 is that they inhibit PTH-related peptide production (75,76); thus, both analogues may also have utility in treating malignancy-associated hypercalcemia.…”

Section: Promising Vitamin D Analogues Under Development For Types Ofmentioning

confidence: 99%

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Promise of vitamin D analogues in the treatment of hyperproliferative conditions

Masuda

Jones

2006

Molecular Cancer Therapeutics

146

109

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Abstract1A,25-Dihydroxyvitamin D 3 [1A,25-(OH) 2 D 3 ; calcitriol] is best known as a hormone involved in calcium homeostasis but is also a potent antiproliferative agent in many cell types, particularly epithelial cells. 1A,25(OH) 2 D 3 mediates its actions through a classic steroid hormone-like transcriptional mechanism by influencing the expression of hundreds of genes. Effects of 1A,25(OH) 2 D 3 have been observed on expression of cell cycle regulators, growth factors and their receptors, apoptotic machinery, metastatic potential, and angiogenesis; all of which have some effect on hyperproliferative conditions. This minireview focuses on the anticancer potential of 1A,25(OH) 2 D 3 and its analogues by summarizing the promising data from animal and human trials of 1A,25(OH) 2 D 3 and some of the more interesting synthetic vitamin D analogues in the treatment of a variety of different animal cancer models and in human patients with advanced cancer. Optimal administration of vitamin D analogues is only just being achieved with high-dose intermittent administration overcoming bioavailability and hypercalcemia problems and combination therapy with cytotoxic agents (taxols and cisplatins), antiresorptive agents (bisphosphonates), or cytochrome P450 inhibitors being attempted. Although the potential of vitamin D as an antiproliferative drug has been realized in the treatment of psoriasis and in parathyroid cell hyperplasia associated with secondary hyperparathyroidism, the search for an anticancer treatment incorporating a vitamin D analogue remains elusive. [Mol Cancer Ther 2006;5(4):797 -808]

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Section: Invasion and Metastasismentioning

confidence: 99%

Section: Promising Vitamin D Analogues Under Development For Types Ofmentioning

confidence: 99%

Promise of vitamin D analogues in the treatment of hyperproliferative conditions

Masuda

Jones

2006

Molecular Cancer Therapeutics

146

109

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“…The anti-tumor actions of OCT were synergistic with those of adriamycin (Abe et al, 1991) and tamoxifen (Abe-Hashimoto et al, 1993). OCT also inhibited growth of rat mammary tumors induced by 7,12-dimethybenz[a]anthracene with no effect on calcium (Oikawa et al, 1991).…”

Section: Colon Cancermentioning

confidence: 95%

Vitamin D analogs: Therapeutic applications and mechanisms for selectivity

Brown

Slatopolsky

2008

Molecular Aspects of Medicine

140

100

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“…75. MECHANISMS FOR THE SELECTIVE ACTIONS OF VITAMIN D ANALOGS [30,31], calcipotriol [32] and EB1089 [33], l,25-(OH) 2 -16-ene-23-yne-26,27-F 6 -vitamin D 3 [34], 1a(OH)D 5 [35], and Gemini analogs [36] inhibited the proliferation of breast cancer cells in vivo. The analogs KH1060, EB1089, and Ro 26-9114 reduced prostate cancer cell (LNCaP) growth in nude mice more effectively than 1,25(OH) 2 D 3 , inducing tumor necrosis and calcification, but with no hypercalcemia [37].…”

Section: Identification Of Selective Vitamin D Analogsmentioning

confidence: 99%

Mechanisms for the Selective Actions of Vitamin D Analogs

Brown

2011

Vitamin D

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Antitumor effect of 22-oxa-1α,25-dihydroxyvitamin D3 a potent angiogenesis inhibitor, on rat mammary tumors induced by 7, 12-dimethylbenz[a]anthracene

Cited by 59 publications

References 0 publications

Promise of vitamin D analogues in the treatment of hyperproliferative conditions

Promise of vitamin D analogues in the treatment of hyperproliferative conditions

Vitamin D analogs: Therapeutic applications and mechanisms for selectivity

Mechanisms for the Selective Actions of Vitamin D Analogs

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