Antitumor and Immunoregulatory Activities of Seleno-β-Lactoglobulin on S180 Tumor-Bearing Mice

Sun, Su-jun; Feng, Yingying; Zhang, Yan; Ji, Haiyu; Yu, Juan; Liu, Anjun

doi:10.3390/molecules23010046

Cited by 8 publications

(3 citation statements)

References 26 publications

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“…IFN-γ has antitumor and immunoregulatory effects. It regulates the expression levels of 30 genes and produces a variety of cellular responses (Sun et al, 2017). IFN-γ also promotes NK cell activity, antigen presentation and increases macrophage lysosomal activity (Zhou et al, 2013;Assani et al, 2014;Takeda et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiome Influences the Efficacy of PD-1 Antibody Immunotherapy on MSS-Type Colorectal Cancer via Metabolic Pathway

et al. 2020

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Changes in gut microbiome leaded to changes in glycerophospholipid metabolism level, which may affect the expression of immune-related cytokines IFN-γ and IL-2 in the tumor microenvironment, resulting in a different therapeutic effect of PD-1 antibody. Our findings show that changes in the gut microbiome affect the glycerophospholipid metabolic pathway, thereby regulating the therapeutic potential of PD-1 antibody in the immunotherapy of MSS-type CRC tumor-bearing mice.

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Section: Discussionmentioning

confidence: 99%

Gut Microbiome Influences the Efficacy of PD-1 Antibody Immunotherapy on MSS-Type Colorectal Cancer via Metabolic Pathway

et al. 2020

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“…As surgery is the main treatment for many malignant tumors, precise localization of the tumor resection area plays a crucial role in the prognosis of patients (9). Currently, the main clinical imaging examinations for localization include computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography/CT (PET/CT), and single photon emission computed tomography (SPECT/CT) (24). However, the above detection methods are often used for preoperative diagnosis and postoperative evaluation, which have little significance for the accurate location of the intraoperative tumor margin.…”

Section: Discussionmentioning

confidence: 99%

Application of an indocyanine green-mediated fluorescence imaging navigation system in detecting mice tumors

Zhao¹,

Wang²,

Wu³

et al. 2021

Ann Transl Med

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Background: Surgical operation plays an important role in the treatment of cancer. The success of the operation lies in the complete removal of the primary and disseminated tumor tissue while preserving the normal tissue. The development of optical molecular image navigation technology has provided a new option for intraoperative tumor visualization. In this study, a fluorescence imaging navigation system was used to detect the diameter of mice tumors and provide experimental evidence for the further development of digital diagnosis and treatment equipment. Methods:The minimum detection concentration in vitro of the fluorescence imaging navigation system for indocyanine green (ICG) was first detected, then 120 female Institute of Cancer Research (ICR) mice and 120 female BALB/c nude mice were randomly divided into three groups by weight, high-dose (H, 4 mg/kg), middle-dose (M, 2 mg/kg), and low-dose (L, 1 mg/kg) groups of ICG solution. After inoculating solid tumors, high, medium, and low doses of ICG were injected via the tail vein, and the tumor diameter was measured by a fluorescence imaging navigation system and vernier caliper within 24 hours of injection. Results:The minimum detectable diameter of the system could reach 0.2 mm compared with the vernier caliper, and the actual measurement error was within 0.2 mm. Conclusions:A fluorescence imaging navigation system has high accuracy and sensitivity in the application of tumor detection, which may assist the clinical diagnosis and treatment of tumors.

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“…Selenium is an essential element in human and low selenium concentration in human body can increase risk of cancer, poor immune function, cognitive and immune system dysfunction (Rayman 2012;Sun et al 2017). b-Lg is the most abundant protein in whey protein containing 162 amino acid residues in each monomer.…”

Section: Discussionmentioning

confidence: 99%

Selenious-β-lactoglobulin induces the apoptosis of human lung cancer A549 cells via an intrinsic mitochondrial pathway

Zhang

et al. 2018

Cytotechnology

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In this study, the cytotoxic activity of selenious-β-lactoglobulin (Se-β-Lg) and the anticancer mechanism were investigated in human lung cancer A549 cells in vitro. MTT assay showed that Se-β-Lg at 200 μg/mL exhibited a significant suppression effect on A549 cells and the maximum inhibition rate reached 90% after 72 h treatment. Flow cytometry analysis revealed that 200 μg/mL of Se-β-Lg induced cell cycle arrest at G/G phase. Cell apoptosis was induced via the generation of reactive oxygen species (ROS) and the decrease of mitochondrial membrane potential (ΔΨm) in a time-dependent manner. Furthermore, Se-β-Lg suppressed the expression of Bcl-2 and improved the level of Bax, leading to the release of cytochrome c and a higher expression of caspase-3 in A549 cells. In summary, Se-β-Lg could induce apoptosis in A549 cells via an intrinsic mitochondrial pathway and it might serve as a potential therapeutic agent for human lung cancer.

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Antitumor and Immunoregulatory Activities of Seleno-β-Lactoglobulin on S180 Tumor-Bearing Mice

Cited by 8 publications

References 26 publications

Gut Microbiome Influences the Efficacy of PD-1 Antibody Immunotherapy on MSS-Type Colorectal Cancer via Metabolic Pathway

Gut Microbiome Influences the Efficacy of PD-1 Antibody Immunotherapy on MSS-Type Colorectal Cancer via Metabolic Pathway

Application of an indocyanine green-mediated fluorescence imaging navigation system in detecting mice tumors

Selenious-β-lactoglobulin induces the apoptosis of human lung cancer A549 cells via an intrinsic mitochondrial pathway

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