Antitumor and apoptotic effects of quercetin on human melanoma cells involving JNK/P38 MAPK signaling activation

Kim, Sung-Hyun; Yoo, Eun‐Seon; Woo, Joong-Seok; Han, Sohee; Lee, Jae-Han; Jung, Seung Won; Kim, Hyeong-Jin; Jung, Ji‐Youn

doi:10.1016/j.ejphar.2019.172568

Cited by 73 publications

(36 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, quercetin showed to inhibit PI3K, MAPK and WNT pathways [102]. Similarly, in melanoma cells, quercetin significantly reduced cellular viability and proliferation, and induced apoptosis involving JNK/P38 MAPK signaling activation [103].…”

Section: Quercetinmentioning

confidence: 99%

The Power of Phytochemicals Combination in Cancer Chemoprevention

Rizeq¹,

Gupta²,

Ilesanmi³

et al. 2020

J. Cancer

120

View full text Add to dashboard Cite

Conventional therapies for cancer treatment have posed many challenges, including toxicity, multidrug resistance and economic expenses. In contrast, complementary alternative medicine (CAM), employing phytochemicals have recently received increased attention owing to their capability to modulate a myriad of molecular mechanisms with a less toxic effect. Increasing evidence from preclinical and clinical studies suggest that phytochemicals can favorably modulate several signaling pathways involved in cancer development and progression. Combinations of phytochemicals promote cell death, inhibit cell proliferation and invasion, sensitize cancerous cells, and boost the immune system, thus making them striking alternatives in cancer therapy. We previously investigated the effect of six phytochemicals (Indol-3-Carbinol, Resveratrol, C-phycocyanin, Isoflavone, Curcumin and Quercetin), at their bioavailable levels on breast cancer cell lines and were compared to primary cell lines over a period of 6 days. This study showed the compounds had a synergestic effect in inhibiting cell proliferation, reducing cellular migration and invasion, inducing both cell cycle arrest and apoptosis. Despite the vast number of basic science and preclinical cancer studies involving phytochemicals, the number of CAM clinical trials in cancer treatment still remains nascent. In this review, we summarize findings from preclinical and clinical studies, including our work involving use of phytochemicals, individually as well as in combination and further discuss the potential of these phytochemicals to pave way to integrate CAM in primary health care.

show abstract

Section: Quercetinmentioning

confidence: 99%

The Power of Phytochemicals Combination in Cancer Chemoprevention

Rizeq¹,

Gupta²,

Ilesanmi³

et al. 2020

J. Cancer

120

View full text Add to dashboard Cite

show abstract

“…Molecular pathways. such as MAPK and JNK, are regulated by natural products in apoptosis induction [ 31 ]. In addition to proliferation, migration, and invasion of cancer cells can be negatively targeted by natural products [ 32 , 33 , 34 ].…”

Section: Role Of Natural Products In Cancer Therapymentioning

confidence: 99%

Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives

et al. 2020

View full text Add to dashboard Cite

Pharmacological profile of phytochemicals has attracted much attention to their use in disease therapy. Since cancer is a major problem for public health with high mortality and morbidity worldwide, experiments have focused on revealing the anti-tumor activity of natural products. Flavonoids comprise a large family of natural products with different categories. Chrysin is a hydroxylated flavonoid belonging to the flavone category. Chrysin has demonstrated great potential in treating different disorders, due to possessing biological and therapeutic activities, such as antioxidant, anti-inflammatory, hepatoprotective, neuroprotective, etc. Over recent years, the anti-tumor activity of chrysin has been investigated, and in the present review, we provide a mechanistic discussion of the inhibitory effect of chrysin on proliferation and invasion of different cancer cells. Molecular pathways, such as Notch1, microRNAs, signal transducer and activator of transcription 3 (STAT3), nuclear factor-kappaB (NF-κB), PI3K/Akt, MAPK, etc., as targets of chrysin are discussed. The efficiency of chrysin in promoting anti-tumor activity of chemotherapeutic agents and suppressing drug resistance is described. Moreover, poor bioavailability, as one of the drawbacks of chrysin, is improved using various nanocarriers, such as micelles, polymeric nanoparticles, etc. This updated review will provide a direction for further studies in evaluating the anti-tumor activity of chrysin.

show abstract

“…Moreover, quercetin also inhibited cell growth in a dose-dependent manner on A375SM human melanoma cells, although conferred no significant effect on A375P human melanoma cell line. Additionally, in vivo treatment with quercetin (50 and 100 mg/kg) significantly reduced tumor volume in comparison with a control group (Kim et al, 2019).…”

Section: Effects On Cell Growth and Proliferationmentioning

confidence: 88%

Quercetin as an anticancer agent: Focus on esophageal cancer

et al. 2020

View full text Add to dashboard Cite

Esophageal cancer (EC) is regarded as the sixth highest contributor to all cancer‐related mortality, worldwide. In spite of advances in the treatment of EC, currently used methods remain ineffective. Quercetin, as a dietary antioxidant, is a plant flavonol from the flavonoid group of polyphenols, and can be found in numerous vegetables, fruits, and herbs. Quercetin can affect the processes of cancer‐related diseases via cell proliferation inhibitory effects, potential apoptosis effects, and antioxidant properties. Of the various types of cancer, the use of quercetin has now become prominent in the treatment of EC. In this review, we discuss how quercetin may be an important supplement for the prevention, treatment, and management of EC, owing to its natural origin, and low‐cost relative to synthetic cancer drugs. However, most findings cited in the current study are based on in vitro and in vivo studies, and thus, further human‐based research is necessitated. Practical applications In spite of advances in the treatment of esophageal cancer, currently used methods remain ineffective, therefore, an alternative or complementary therapy is required. Quercetin, as a dietary antioxidant, can affect the processes of cancer‐related diseases via cell proliferation inhibitory effects, potential proapoptotic functions, and antioxidant properties. Quercetin may be an important supplement for the prevention, treatment, and management of EC, owing to its natural origin. The low cost of quercetin as supplement or dietary intake, relative to synthetic cancer drugs, is an advantage of the compound which should be considered.

show abstract

Antitumor and apoptotic effects of quercetin on human melanoma cells involving JNK/P38 MAPK signaling activation

Cited by 73 publications

References 27 publications

The Power of Phytochemicals Combination in Cancer Chemoprevention

The Power of Phytochemicals Combination in Cancer Chemoprevention

Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives

Quercetin as an anticancer agent: Focus on esophageal cancer

Contact Info

Product

Resources

About