Antitumor and Antimicrobial Potential of Bromoditerpenes Isolated from the Red Alga, Sphaerococcus coronopifolius

Rodrigues, Daniel; Alves, Celso; Horta, André; Pintéus, Susete; Silva, Joana; Culioli, Gérald; Thomas, Olivier P.; Pedrosa, Rui

doi:10.3390/md13020713

Cited by 69 publications

(42 citation statements)

References 41 publications

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“…Still. mainly the terpernoids found in red seaweeds have demonstrated a high antitumor bioactivity [8,[54][55][56]. Most of terpenoids with the variation in their structures are biologically active and are used worldwide for illnesses treatment [41].…”

Section: Terpenesmentioning

confidence: 99%

A Comprehensive Review of the Nutraceutical and Therapeutic Applications of Red Seaweeds (Rhodophyta)

Cotas

Leandro

Pacheco

et al. 2020

Life

134

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The red seaweed group (Rhodophyta) is one of the phyla of macroalgae, among the groups Phaeophyceae and Chlorophyta, brown and green seaweeds, respectively. Nowadays, all groups of macroalgae are getting the attention of the scientific community due to the bioactive substances they produce. Several macroalgae products have exceptional properties with nutraceutical, pharmacological, and biomedical interest. The main compounds studied are the fatty acids, pigments, phenols, and polysaccharides. Polysaccharides are the most exploited molecules, which are already widely used in various industries and are, presently, entering into more advanced applications from the therapeutic point of view. The focuses of this review are the red seaweeds’ compounds, its proprieties, and its uses. Moreover, this work discusses new possible applications of the compounds of the red seaweeds.

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Section: Terpenesmentioning

confidence: 99%

A Comprehensive Review of the Nutraceutical and Therapeutic Applications of Red Seaweeds (Rhodophyta)

Cotas

Leandro

Pacheco

et al. 2020

Life

134

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“…Red [101] Callophycus serratus Diterpene-benzoate Red [98] Antibacterial activity is expressed across multiple mechanisms: inhibition of oxidative phosphorylation and link with compounds in the bacterial cell wall and increased permeability of the cytoplasmic membrane causing cell lysis [97]. At the same time some seaweed compounds, in particular polysaccharides, contribute significantly to the health and well-being of the animals by enhancing the in vivo immune response.…”

Section: Sphaerane Bromoditerpenesmentioning

confidence: 99%

Seaweeds in Pig Nutrition

Corino

Modina

Giancamillo

et al. 2019

Animals

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Simple Summary: In pig nutrition, alternative and safe supplements are needed to enhance the pigs' health and welfare. Natural feed components, such as herbs and plant extracts, are of great importance in animal nutrition, and marine macroalgae can be considered as supplements positively influence animal health parameters. Seaweeds possess several bioactive molecules that are studied for their prebiotic, anti-microbial, antioxidant, anti-inflammatory and immunomodulatory effects. Seaweed benefits are related to their content of sulfated polysaccharides, phlorotannins, diterpenes, omega-3 polyunsaturated fatty acids, minerals and vitamins. This paper reviews the following biological functions of seaweeds and seaweed extracts in pig nutrition: prebiotics, anti-microbial, antioxidant, anti-inflammatory and immunomodulatory effects, promoting intestinal well-being and improving digestibility.Abstract: Seaweeds are macroalgae, with different sizes, colors and composition. They consist of brown algae, red algae and green algae, which all have a different chemical composition and bioactive molecule content. The polysaccharides, laminarin and fucoidan are commonly present in brown seaweeds, ulvans are found in green seaweeds and, red algae contain a large amount of carrageenans. These bioactive compounds may have several positive effects on health in livestock. In order to reduce the antimicrobials used in livestock, research has recently focused on finding natural and sustainable molecules that boost animal performance and health. The present study thus summarizes research on the dietary integration of seaweeds in swine. In particular the influence on growth performance, nutrients digestibility, prebiotic, antioxidant, anti-inflammatory, and immunomodulatory activities were considered. The review highlights that brown seaweeds seem to be a promising dietary intervention in pigs in order to boost the immune system, antioxidant status and gut health. Data on the use of green seaweeds as a dietary supplementation seems to be lacking at present and merit further investigation.(Bacillariophyceae), green algae (Chlorophyceae) and golden algae (Chrysophyceae) are the most abundant but blue-green algae (Cyanophyceae) are also defined as microalgae [2]. The bioactive molecules of microalgae are used as food and feed supplements [3].Seaweeds are marine organisms and comprise thousands of species, which are classified on the basis of their pigmentation: brown seaweeds (Phaeophyceae), red seaweeds (Rhodophyceae) and green seaweeds (Chlorophyceae).There are around 1800 species of brown seaweeds include, only 1% of which are recognized from freshwater and the size range varies from 20 m to 30 cm long. The brown color of these algae is related to the main content of carotenoid fucoxanthin, which masks β-carotene, violaxanthin, diatoxanthin, and chlorophyll. The main polysaccharides are laminarin, fucoidans and alginates, and the cell walls are composed of cellulose and alginic acid [4].Like brown seaweeds, red algae (about 6100 specie...

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“…Previous studies carried out with extracts from the red algae S. coronopifolius showed that it possesses several biological effects, such as antioxidant, antimicrobial, antitumor and antiviral potential due to the presence of active secondary metabolites 10,11,12 . Furthermore, the effect of S. coronopifolius phenolic extracts on anxiety-like behavior in female Wistar rats was attempted 13 .…”

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confidence: 99%

Untitled

2020

IJPSR

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Neuropathic pain is commonly comorbid with mood disorders, such as depression and anxiety. A state of depression may suggest biochemical imbalance that can increase the oxidative stress into the brain. The present study aimed to investigate the effect of aqueous extract of the red algae Sphaerococcus coronopifolius on depression-induced behavioral alterations and oxidative stress in female Wistar rats. Sciatic nerve injury was employed to induce depression in rats. Antidepressant-like effect of S. coronopifolius was investigated using two models: the forced swimming test (FST) and the open field test (OP). Three groups of rats were considered: The first group served as a control. The second group was subjected to sciatic nerve ligation (untreated group). The third group was subjected to sciatic nerve ligation treated daily by intraperitoneal injection of 25 mg algae extract kg−1 body weight of rat during two consecutive weeks(treated group). At the end of the experiment, rats were sacrificed and brain tissues were isolated to determine the activities of catalase (CAT) and glutathione-S-transferase (GST) as well as the level of reduced glutathione (GSH).The results showed that the sciatic nerve ligation caused a depression-like behavior in female rats in contrast with the algae extract that demonstrated an antidepressant-like activity. The results obtained in the open field showed a preserved spontaneous locomotion. Untreated rats showed a significant decrease of GSH and antioxidant enzymes, and it seems that algae extract ameliorate CAT and GST activities. INTRODUCTION: Neuropathic pain is commonly comorbid with mood disorders such as depression and anxiety 1. Depression is one of the top five most prevalent diseases worldwide 2. Furthermore, depression will be ranked second as measured by DALY (Disability Adjusted Life Years) for all ages by 2020. 3 QUICK RESPONSE CODE

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Antitumor and Antimicrobial Potential of Bromoditerpenes Isolated from the Red Alga, Sphaerococcus coronopifolius

Cited by 69 publications

References 41 publications

A Comprehensive Review of the Nutraceutical and Therapeutic Applications of Red Seaweeds (Rhodophyta)

A Comprehensive Review of the Nutraceutical and Therapeutic Applications of Red Seaweeds (Rhodophyta)

Seaweeds in Pig Nutrition

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