Antitumor agents XLII: Comparison of Antileukemic Activity of Helenalin, Brusatol, and Bruceantin and their Esters on Different Strains of p-388 Lymphocytic Leukemic Cells

Hall, Iris H.; Lee, K.H.; Okano, Masayoshi; Sims, Donald; Ibuka, Toshiro; Liou, Y.F.; Imakura, Yasuhiro

doi:10.1002/jps.2600701014

Cited by 31 publications

(11 citation statements)

References 19 publications

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“…The DNA acid-insoluble precipitate was collected by vacuum suction on GF/F glass fiber discs which were washed with cold 10% perchloric acid containing 1% sodium pyr~phosphate.~~ Acid-insoluble precipitates from the RNA and protein experiments were collected on GF/B and Whatman 8 3 filters, respectively, and were washed with 10% trichloroacetic acid. The filter discs were dried, placed in Scintiverse, and counted in a Packard Scintillation Counter 32. The following enzymatic activities were determined in cells at multiples ofthe ED,, values for each drug.…”

mentioning

confidence: 99%

Synthesis and Antineoplastic Activity of Some Cyano-, Carboxy-, Carbomethoxy-, and Carbamoylborane Adducts of Heterocyclic Amines

Sood

Sood²,

Spielvogel³

et al. 1991

Journal of Pharmaceutical Sciences

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mentioning

confidence: 99%

Synthesis and Antineoplastic Activity of Some Cyano-, Carboxy-, Carbomethoxy-, and Carbamoylborane Adducts of Heterocyclic Amines

Sood

Sood²,

Spielvogel³

et al. 1991

Journal of Pharmaceutical Sciences

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“…Bruceantin and brusatol are two important representatives of these constituents possessing antileukemic activity. Structurally, bruceantin and brusatol differ from each other only in the acid moiety [88].…”

Section: Quassinoidsmentioning

confidence: 99%

Recent Development of Antitumor Agents from Chinese Herbal Medicines; Part I. Low Molecular Compounds

2003

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A series of low molecular compounds from Chinese herbal medicines which have proved to be, in some cases, highly effective especially in tumor therapy, is listed here (part II will deal with high molecular compounds, to be published in the next issue). In contrast to synthetic agents used in cancer chemotherapy, these natural compounds have relatively low toxicities. Many of the clinical studies referred to in this paper have been carried out on Asians. Because genetic factors influence enzyme levels, sometimes leading to striking differences in metabolism and pharmacokinetics of drugs, results obtained in clinical studies carried out in China are not 100 % transferable to the European population. The mechanisms of action of these compounds are manifold, consisting of reactions with DNA bases, intercalation in DNA, inhibition of topoisomerases, inhibition of protein kinases, induction of apoptosis etc. Some of the compounds have interesting structural features, that may be used as lead structures for the development of further antitumor agents.

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“…This has been explained by the fact that it possesses two alkylating structure elements (e.g. [23][24][25][26][27]. However, bioactivity is not always correlated with the number of potential alkylating centers (28).…”

Section: Biological Activities Of Arnica Sesquiterpene Lactonesmentioning

confidence: 99%

Arnica Flowers: Pharmacology, Toxicolgy, and Analysis of the Sesquiterpene Lactones—Their Main Active Substances

Willuhn

1998

ACS Symposium Series

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Arnica flowers from the European Compositae Arnica montana have been used in traditional medicine to treat a large variety of different ailments. It has been shown that the known diverse effects of the flowers correlate closely with the pharmacological and toxicological profile of their constituents helenalin, 11α,13-dihydrohelenalin and their esters, which therefore must be considered as their main active compounds. Methods for their qualitative and quantitative determination have been established and the variability in flowers from different geographical origin investigated. Arnica chamissonis ssp. foliosa is used as alternative source for the official "Arnicae flos." In addition to the sesquiterpene lactones of A. montana, they contain 2,3-dihydro-2α-hydroxy-and 2,3-dihydro-2α-,4α-dihydroxy-helenanolide derivatives. The qualitative and quantitative variation is much larger than in the case of A. montana flowers, but populations exist equal to that of A. montana.Arnica flowers from the European Arnica montana L. have been extensively used in traditional medicine to treat a large variety of different ailments. First written records exist from the 16th century when Arnica flowers were used externally and internally in injuries and accidents such as sprains, dislocations, haematomas and oedema associated with fractures. Many vernacular names for this medicinal plant from that time, such as "fall herb", "break herb" or "wound herb" point to this indication. In the following centuries the range of indications for Arnica flowers was enlarged to include treatment of heart and circulatory diseases, chronical diseases such as asthma and rheumatic pains, feverish conditions, menstruation complaints and many other diseases. The plant was named "Panacea lapsorum" after the hypothetical medicine "Panazee," of which the ancient physicians were always dreaming. This imagined 118

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Antitumor agents XLII: Comparison of Antileukemic Activity of Helenalin, Brusatol, and Bruceantin and their Esters on Different Strains of p-388 Lymphocytic Leukemic Cells

Cited by 31 publications

References 19 publications

Synthesis and Antineoplastic Activity of Some Cyano-, Carboxy-, Carbomethoxy-, and Carbamoylborane Adducts of Heterocyclic Amines

Synthesis and Antineoplastic Activity of Some Cyano-, Carboxy-, Carbomethoxy-, and Carbamoylborane Adducts of Heterocyclic Amines

Recent Development of Antitumor Agents from Chinese Herbal Medicines; Part I. Low Molecular Compounds

Arnica Flowers: Pharmacology, Toxicolgy, and Analysis of the Sesquiterpene Lactones—Their Main Active Substances

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