Antitumor Agents XLI: Effects of Eupaformosanin on Nucleic Acid, Protein, and Anaerobic and Aerobic Glycolytic Metabolism of Ehrlich Ascites Cells

Hall, Iris H.; Lee, K.H.; Williams, W.L.; Kimura, Takeatsu; Hirayama, Toshiya

doi:10.1002/jps.2600690313

Cited by 11 publications

(4 citation statements)

References 40 publications

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“…It has been demonstrated that Eup, a natural compound isolated from Eupatorium cannabinum Linn., has anti-tumor activity (22). Nevertheless, studies on its anti-tumor effects on TNBC have not been reported until now.…”

Section: Discussionmentioning

confidence: 99%

“…has diverse bioactivities, for example, SLs eupatoriopicrin could inhibit the proliferation of lung cancer, and its anti-in ammatory activity was also con rmed with suppression of a series of in ammatory factors (19)(20)(21). As a natural compound similar to eupatoriopicrin, Eup has attracted a little attention, and there are reported that Eup could restrain Ehrlich ascites cell metabolism through inhibiting deoxyribonucleic acid synthesis (22). Nevertheless, the role of Eup in TNBC remains unexplored.…”

Section: Introductionmentioning

confidence: 99%

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Eupaformosanin induces apoptosis and ferroptosis through ubiquitination of mutant p53 in triple-negative breast cancer

Wei

Zhu

et al. 2022

European Journal of Pharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Eupaformosanin induces apoptosis and ferroptosis through ubiquitination of mutant p53 in triple-negative breast cancer

Wei

Zhu

et al. 2022

European Journal of Pharmacology

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“…Recent studies have revealed that sesquiterpene lactones can induce apoptosis and ferroptosis by targeting the ubiquitination of GPX4 in TNBC 220 . Among these compounds, Eupaformosanin, a natural product extracted from Eupatorium cannabinum Linn, has exhibited inhibitory effects on the metabolism of Ehrlich ascites cells by suppressing DNA synthesis 221 . Wei et al 222 .…”

Section: Natural Compounds Targeting Ferroptosis In Breast Cancermentioning

confidence: 99%

“… 220 Among these compounds, Eupaformosanin, a natural product extracted from Eupatorium cannabinum Linn, has exhibited inhibitory effects on the metabolism of Ehrlich ascites cells by suppressing DNA synthesis. 221 Wei et al. 222 conducted research demonstrating that Eupaformosanin effectively suppresses the viability of TNBC cells.…”

Section: Natural Compounds Targeting Ferroptosis In Breast Cancermentioning

confidence: 99%

Mechanism of ferroptosis in breast cancer and research progress of natural compounds regulating ferroptosis

Ge,

He,

Zhao

et al. 2023

J Cellular Molecular Medi

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Breast cancer is the most prevalent cancer worldwide and its incidence increases with age, posing a significant threat to women's health globally. Due to the clinical heterogeneity of breast cancer, the majority of patients develop drug resistance and metastasis following treatment. Ferroptosis, a form of programmed cell death dependent on iron, is characterized by the accumulation of lipid peroxides, elevated levels of iron ions and lipid peroxidation. The underlying mechanisms and signalling pathways associated with ferroptosis are intricate and interconnected, involving various proteins and enzymes such as the cystine/glutamate antiporter, glutathione peroxidase 4, ferroptosis inhibitor 1 and dihydroorotate dehydrogenase. Consequently, emerging research suggests that ferroptosis may offer a novel target for breast cancer treatment; however, the mechanisms of ferroptosis in breast cancer urgently require resolution. Additionally, certain natural compounds have been reported to induce ferroptosis, thereby interfering with breast cancer. Therefore, this review not only discusses the molecular mechanisms of multiple signalling pathways that mediate ferroptosis in breast cancer (including metastasis, invasion and proliferation) but also elaborates on the mechanisms by which natural compounds induce ferroptosis in breast cancer. Furthermore, this review summarizes potential compound types that may serve as ferroptosis inducers in future tumour cells, providing lead compounds for the development of ferroptosis‐inducing agents. Last, this review proposes the potential synergy of combining natural compounds with traditional breast cancer drugs in the treatment of breast cancer, thereby suggesting future directions and offering new insights.

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Antitumor Agents LXIII: The Effects of Microlenin on Nucleic Acid and Protein Syntheses of Ehrlich Ascites Cells

Hall

Lee

Imakura

et al. 1983

Journal of Pharmaceutical Sciences

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Antitumor Agents XLI: Effects of Eupaformosanin on Nucleic Acid, Protein, and Anaerobic and Aerobic Glycolytic Metabolism of Ehrlich Ascites Cells

Cited by 11 publications

References 40 publications

Eupaformosanin induces apoptosis and ferroptosis through ubiquitination of mutant p53 in triple-negative breast cancer

Eupaformosanin induces apoptosis and ferroptosis through ubiquitination of mutant p53 in triple-negative breast cancer

Mechanism of ferroptosis in breast cancer and research progress of natural compounds regulating ferroptosis

Antitumor Agents LXIII: The Effects of Microlenin on Nucleic Acid and Protein Syntheses of Ehrlich Ascites Cells

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